scholarly journals Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
David K. Cole ◽  
Kathleen Gallagher ◽  
Brigitte Lemercier ◽  
Christopher J. Holland ◽  
Sayed Junaid ◽  
...  
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Selection ◽  
Flanking Region ◽  
Carboxy Terminal

scholarly journals T Cell Receptor (Tcr)-Mediated Repertoire Selection and Loss of Tcr Vβ Diversity during the Initiation of a Cd4+ T Cell Response in Vivo

2000 ◽  
Vol 192 (12) ◽  
pp. 1719-1730 ◽  
Author(s):  
Marcella Fassò ◽  
Niroshana Anandasabapathy ◽  
Frances Crawford ◽  
John Kappler ◽  
C. Garrison Fathman ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Selection

We recently described a novel way to isolate populations of antigen-reactive CD4+ T cells with a wide range of reactivity to a specific antigen, using immunization with a fixed dose of nominal antigen and FACS® sorting by CD4high expression. Phenotypic, FACS®, functional, antibody inhibition, and major histocompatibility complex–peptide tetramer analyses, as well as T cell receptor Vβ sequence analyses, of the antigen-specific CD4high T cell populations demonstrated that a diverse sperm whale myoglobin 110–121–reactive CD4+ T cell repertoire was activated at the beginning (day 3 after immunization) of the immune response. Within 6 d of immunization, lower affinity clones were lost from the responding population, leaving an expanded population of oligoclonal, intermediate affinity (and residual high affinity) T cells. This T cell subset persisted for at least 4 wk after immunization and dominated the secondary immune response. These data provide evidence that CD4+ T cell repertoire selection occurs early in the immune response in vivo and suggest that persistence and expansion of a population of oligoclonal, intermediate affinity T cells is involved in CD4+ T cell memory.

Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire

2005 ◽  
Vol 62 (1) ◽  
pp. 77-86 ◽  
Author(s):  
M. -D. Nastke† ◽  
L. Herrgen† ◽  
S. Walter ◽  
D. Wernet ◽  
H. -G. Rammensee ◽  
...  
Keyword(s):  
T Cell ◽  
Human Cytomegalovirus ◽  
Cd4 T Cell ◽  
T Cell Epitopes ◽  
T Cell Repertoire ◽  
Cell Repertoire

scholarly journals Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+T cell repertoire by favoring CD95-mediated apoptosis

2005 ◽  
Vol 78 (2) ◽  
pp. 372-382 ◽  
Author(s):  
Cristiano Scottà ◽  
Loretta Tuosto ◽  
Anna Maria Masci ◽  
Luigi Racioppi ◽  
Enza Piccolella ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Hypervariable Region ◽  
Cd4 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Hypervariable Region 1

scholarly journals Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23

2018 ◽  
Vol 155 (4) ◽  
pp. 1177-1191.e16 ◽  
Author(s):  
Lili Chen ◽  
Zhengxiang He ◽  
Alina Cornelia Iuga ◽  
Sebastião N. Martins Filho ◽  
Jeremiah J. Faith ◽  
...  
Keyword(s):  
T Cell ◽  
Myeloid Cell ◽  
Cd4 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Colonic Microbiota ◽  
Interleukin 23 ◽  
Cell Expression

scholarly journals Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

2003 ◽  
Vol 100 (4) ◽  
pp. 1861-1866 ◽  
Author(s):  
M. M. Martinic ◽  
T. Rulicke ◽  
A. Althage ◽  
B. Odermatt ◽  
M. Hochli ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Repertoire ◽  
Chimeric Mice ◽  
Cell Repertoire ◽  
Repertoire Selection
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