Antigen‐driven T‐cell repertoire selection during adaptive immune responses

2010 ◽  
Vol 89 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Christina K Baumgartner ◽  
Laurent P Malherbe
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Repertoire Selection

scholarly journals T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

2021 ◽  
Author(s):  
Jianhua Xu ◽  
Yaling Shi ◽  
Yongsi Wang ◽  
Yuntao Liu ◽  
Dongzi Lin ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Recurrent Infection ◽  
Cell Receptor ◽  
Development Project ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Asymptomatic Patients ◽  
Tcr Repertoire ◽  
Innovation Project

AbstractBackgroundThe prevention of COVID-19 pandemic is highly complicated by the prevalence of asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic and convalescent patients, while the immune responses in asymptomatic patients and re-detectable positive cases remain unclear.MethodsHere we comprehensively analyzed the peripheral T-cell receptor (TCR) repertoire of 54 COVID-19 patients in different phases, including asymptomatic, symptomatic, convalescent and re-detectable positive cases.ResultsWe found progressed immune responses from asymptomatic to symptomatic phase. Furthermore, the TCR profiles of re-detectable positive cases were highly similar to those of asymptomatic patients, which could predict the risk of recurrent infection.ConclusionTherefore, TCR repertoire surveillance has the potential to strengthen the clinical management and the immunotherapy development for COVID-19.FundingThe Science and Technology Innovation Project of Foshan Municipality (2020001000431) and the National Key Research and Development Project (2020YFA0708001).

scholarly journals Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

2003 ◽  
Vol 100 (4) ◽  
pp. 1861-1866 ◽  
Author(s):  
M. M. Martinic ◽  
T. Rulicke ◽  
A. Althage ◽  
B. Odermatt ◽  
M. Hochli ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Repertoire ◽  
Chimeric Mice ◽  
Cell Repertoire ◽  
Repertoire Selection

scholarly journals Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
David K. Cole ◽  
Kathleen Gallagher ◽  
Brigitte Lemercier ◽  
Christopher J. Holland ◽  
Sayed Junaid ◽  
...  
Keyword(s):  
T Cell ◽  
Cd4 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Selection ◽  
Flanking Region ◽  
Carboxy Terminal

scholarly journals The immunoreceptor adapter protein DAP12 suppresses B lymphocyte–driven adaptive immune responses

2011 ◽  
Vol 208 (8) ◽  
pp. 1661-1671 ◽  
Author(s):  
Takako Nakano-Yokomizo ◽  
Satoko Tahara-Hanaoka ◽  
Chigusa Nakahashi-Oda ◽  
Tsukasa Nabekura ◽  
Nadia K. Tchao ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Immune Responses ◽  
B Cell ◽  
Genetic Disorder ◽  
Elevated Serum ◽  
Sh2 Domain ◽  
Adapter Protein ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

DAP12, an immunoreceptor tyrosine-based activation motif–bearing adapter protein, is involved in innate immunity mediated by natural killer cells and myeloid cells. We show that DAP12-deficient mouse B cells and B cells from a patient with Nasu-Hakola disease, a recessive genetic disorder resulting from loss of DAP12, showed enhanced proliferation after stimulation with anti-IgM or CpG. Myeloid-associated immunoglobulin-like receptor (MAIR) II (Cd300d) is a DAP12-associated immune receptor. Like DAP12-deficient B cells, MAIR-II–deficient B cells were hyperresponsive. Expression of a chimeric receptor composed of the MAIR-II extracellular domain directly coupled to DAP12 into the DAP12-deficient or MAIR-II–deficient B cells suppressed B cell receptor (BCR)–mediated proliferation. The chimeric MAIR-II–DAP12 receptor recruited the SH2 domain–containing protein tyrosine phosphatase 1 (SHP-1) after BCR stimulation. DAP12-deficient mice showed elevated serum antibodies against self-antigens and enhanced humoral immune responses against T cell–dependent and T cell–independent antigens. Thus, DAP12-coupled MAIR-II negatively regulates B cell–mediated adaptive immune responses.

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