scholarly journals Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

Nature ◽  
2010 ◽  
Vol 468 (7320) ◽  
pp. 98-102 ◽  
Author(s):  
Daniel Schramek ◽  
Andreas Leibbrandt ◽  
Verena Sigl ◽  
Lukas Kenner ◽  
John A. Pospisilik ◽  
...  
Keyword(s):  
Mammary Cancer ◽  
Osteoclast Differentiation ◽  
Differentiation Factor ◽  
Osteoclast Differentiation Factor

scholarly journals Lipopolysaccharides of Fusobacterium nucleatum and Porphyromonas gingivalis increase RANKL-expressing neutrophils in air pouches of mice

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Ae Ri Kim ◽  
Yun Kyong Lim ◽  
Joong-Ki Kook ◽  
Eun-Jung Bak ◽  
Yun-Jung Yoo
Keyword(s):  
Flow Cytometry ◽  
Porphyromonas Gingivalis ◽  
Osteoclast Differentiation ◽  
Fusobacterium Nucleatum ◽  
Pathological Changes ◽  
Air Pouch ◽  
E Coli ◽  
Differentiation Factor ◽  
Osteoclast Differentiation Factor

AbstractIncreases of neutrophils and osteoclasts are pathological changes of periodontitis. RANKL is an osteoclast differentiation factor. The effect of periodontopathogen LPS on RANKL-expressing neutrophils has not been clarified yet. We evaluated numerical changes of RANKL-expressing neutrophils in air pouches of mice injected with LPSs of Fusobacterium nucleatum and Porphyromonas gingivalis. Mice with air pouches were assigned into saline (C)-, E. coli LPS- (Ec LPS)-, F. nucleatum LPS (Fn LPS)-, P. gingivalis LPS (Pg LPS)-, and Fn LPS and Pg LPS (Fn + Pg LPS)-injected groups. CD11b+Ly6G+ neutrophils and CD11b+Ly6G+RANKL+ neutrophils in blood and air pouch exudates were determined by flow cytometry. In blood, compared to the C group, the Fn LPS group showed increases of CD11b+Ly6G+ neutrophils and CD11b+Ly6G+RANKL+ neutrophils whereas the Pg LPS group showed no significant differences. These increases in the Fn LPS group were not different to those in the Ec LPS group. In exudates, Fn LPS and Pg LPS groups showed increases of CD11b+Ly6G+ neutrophils and CD11b+Ly6G+RANKL+ neutrophils compared to the C group. Increased levels in the Fn LPS group were not different to those in the Ec LPS group, but Pg LPS group was lower than those in the Ec LPS group. In blood and exudates, the Fn + Pg LPS group showed no difference in levels of these neutrophils compared to the Ec LPS group. LPSs of F. nucleatum and P. gingivalis increased RANKL-expressing neutrophils although the degrees of increases were different. These suggest that periodontopathogen LPS can act as a stimulant to increase RANKL-expressing neutrophils.

scholarly journals Gene Expression of Osteoclast Differentiation Factor Is Induced by Lipopolysaccharide in Mouse Osteoblasts Via Toll-Like Receptors

2001 ◽  
Vol 166 (5) ◽  
pp. 3574-3579 ◽  
Author(s):  
Takeshi Kikuchi ◽  
Tetsuya Matsuguchi ◽  
Naotake Tsuboi ◽  
Akio Mitani ◽  
Shigehisa Tanaka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Osteoclast Differentiation ◽  
Toll Like Receptors ◽  
Differentiation Factor ◽  
Osteoclast Differentiation Factor

Low Calcium Environment Effects Osteoprotegerin Ligand/Osteoclast Differentiation Factor

2000 ◽  
Vol 276 (2) ◽  
pp. 524-529 ◽  
Author(s):  
Sadaaki Takeyama ◽  
Yoshitaka Yoshimura ◽  
Yoichi Shirai ◽  
Yoshiaki Deyama ◽  
Tomokazu Hasegawa ◽  
...  
Keyword(s):  
Osteoclast Differentiation ◽  
Environment Effects ◽  
Low Calcium ◽  
Differentiation Factor ◽  
Osteoclast Differentiation Factor ◽  
Osteoprotegerin Ligand
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