Rad54 protein promotes branch migration of Holliday junctions

Nature ◽  
2006 ◽  
Vol 442 (7102) ◽  
pp. 590-593 ◽  
Author(s):  
Dmitry V. Bugreev ◽  
Olga M. Mazina ◽  
Alexander V. Mazin
Keyword(s):  
Holliday Junctions ◽  
Branch Migration

scholarly journals A mutation in helicase motif III ofE.coliRecG protein abolishes branch migration of Holliday junctions

1994 ◽  
Vol 22 (3) ◽  
pp. 308-313 ◽  
Author(s):  
Gary J. Sharples ◽  
Matthew C. Whitby ◽  
Lizanne Ryder ◽  
Robert G. Lloyd
Keyword(s):  
Holliday Junctions ◽  
Branch Migration

Abstract 2112: CA-microsatellite instability as a factor of branch migration impeding in Holliday junctions

2012 ◽  
Author(s):  
Natalia Y. Karpechenko ◽  
Nina G. Dolinnaya ◽  
Vladimir I. Popenko ◽  
Marianna G. Yakubovskaya ◽  
Victoria K. Gasanova
Keyword(s):  
Microsatellite Instability ◽  
Holliday Junctions ◽  
Branch Migration

Structural analysis of the E. coli RUVB branch migration protein by EM and image analysis

1994 ◽  
Vol 52 ◽  
pp. 336-337
Author(s):  
X. Yu ◽  
K. Benson ◽  
A. Stasiak ◽  
I. Tsaneva ◽  
S. West ◽  
...  
Keyword(s):  
Image Analysis ◽  
Atp Hydrolysis ◽  
Genetic Recombination ◽  
Sos Response ◽  
Structure And Function ◽  
Holliday Junctions ◽  
Branch Migration ◽  
E Coli ◽  
Form Part ◽  
And Function

We have been interested in the structure and function of proteins involved in genetic recombinaton. The ruv locus on the E. coli chromosome contains three genes (ruvA, ruvB and ruvC) that are important for genetic recombination and DNA repair. The ruvA and ruvB genes form part of the SOS response to DNA damage and encode the RuvA and RuvB proteins. Together, RuvA and RuvB promote the branch migration of Holliday junctions in a reaction that requires ATP hydrolysis. Each protein plays a defined role, with RuvA responsible for DNA binding (and, in particular, junction recognition), whereas the RuvB ATPase provides the motor for branch migration. Sequence analysis has identified RuvB as a member of a superfamily of helicases, and experimentally it has been shown that RuvB, in the presence of RuvA, acts as an ATP-dependent helicase.When purified RuvB protein was incubated (in the presence of the ATP analog, ATP-γ-S) with covalently closed, relaxed dsDNA, double-ringed structures were observed on the DNA in the electron microscope (Fig. 1). The DNA must be passing through the center of these rings, since the rings are always aligned along a common axis.

scholarly journals The Bloom's syndrome gene product promotes branch migration of Holliday junctions

2000 ◽  
Vol 97 (12) ◽  
pp. 6504-6508 ◽  
Author(s):  
J. K. Karow ◽  
A. Constantinou ◽  
J.-L. Li ◽  
S. C. West ◽  
I. D. Hickson
Keyword(s):  
Gene Product ◽  
Holliday Junctions ◽  
Branch Migration ◽  
Bloom's Syndrome ◽  
Bloom’S Syndrome
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