Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Nature ◽  
2006 ◽  
Vol 439 (7075) ◽  
pp. 484-489 ◽  
Author(s):  
Mitsuhiro Watanabe ◽  
Sander M. Houten ◽  
Chikage Mataki ◽  
Marcelo A. Christoffolete ◽  
Brian W. Kim ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Energy Expenditure ◽  
Bile Acids

scholarly journals The Small Polyphenolic Molecule Kaempferol Increases Cellular Energy Expenditure and Thyroid Hormone Activation

Diabetes ◽  
2007 ◽  
Vol 56 (3) ◽  
pp. 767-776 ◽  
Author(s):  
W. S. da-Silva ◽  
J. W. Harney ◽  
B. W. Kim ◽  
J. Li ◽  
S. D.C. Bianco ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Energy Expenditure ◽  
Cellular Energy

Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans

2012 ◽  
Vol 97 (2) ◽  
pp. 535-542 ◽  
Author(s):  
Johann Ockenga ◽  
Luzia Valentini ◽  
Tatjana Schuetz ◽  
Franziska Wohlgemuth ◽  
Silja Glaeser ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Bile Acids ◽  
Thyroid Function

scholarly journals Thyroid Hormone Mediated Modulation of Energy Expenditure

2015 ◽  
Vol 16 (7) ◽  
pp. 16158-16175 ◽  
Author(s):  
Janina Vaitkus ◽  
Jared Farrar ◽  
Francesco Celi
Keyword(s):  
Thyroid Hormone ◽  
Energy Expenditure

scholarly journals Liver X receptor β controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue

2015 ◽  
Vol 112 (45) ◽  
pp. 14006-14011 ◽  
Author(s):  
Yifei Miao ◽  
Wanfu Wu ◽  
Yubing Dai ◽  
Laure Maneix ◽  
Bo Huang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Energy Expenditure ◽  
White Adipose Tissue ◽  
Uncoupling Protein ◽  
Thyroid Stimulating Hormone ◽  
Vital Role ◽  
Normal Diet ◽  
Subcutaneous White Adipose Tissue ◽  
Brown Adipose

The recent discovery of browning of white adipose tissue (WAT) has raised great research interest because of its significant potential in counteracting obesity and type 2 diabetes. Browning is the result of the induction in WAT of a newly discovered type of adipocyte, the beige cell. When mice are exposed to cold or several kinds of hormones or treatments with chemicals, specific depots of WAT undergo a browning process, characterized by highly activated mitochondria and increased heat production and energy expenditure. However, the mechanisms underlying browning are still poorly understood. Liver X receptors (LXRs) are one class of nuclear receptors, which play a vital role in regulating cholesterol, triglyceride, and glucose metabolism. Following our previous finding that LXRs serve as repressors of uncoupling protein-1 (UCP1) in classic brown adipose tissue in female mice, we found that LXRs, especially LXRβ, also repress the browning process of subcutaneous adipose tissue (SAT) in male rodents fed a normal diet. Depletion of LXRs activated thyroid-stimulating hormone (TSH)-releasing hormone (TRH)-positive neurons in the paraventricular nucleus area of the hypothalamus and thus stimulated secretion of TSH from the pituitary. Consequently, production of thyroid hormones in the thyroid gland and circulating thyroid hormone level were increased. Moreover, the activity of thyroid signaling in SAT was markedly increased. Together, our findings have uncovered the basis of increased energy expenditure in male LXR knockout mice and provided support for targeting LXRs in treatment of obesity.

Sign in / Sign up

Export Citation Format

Share Document