scholarly journals AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice

2016 ◽  
Vol 3 ◽  
pp. 15055 ◽  
Author(s):  
Vera Lukashchuk ◽  
Katherine E Lewis ◽  
Ian Coldicott ◽  
Andrew J Grierson ◽  
Mimoun Azzouz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Delivery ◽  
Targeted Gene Delivery ◽  
Cisterna Magna

In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery

2010 ◽  
Vol 92 (3) ◽  
pp. 227-244 ◽  
Author(s):  
Jochen De Vry ◽  
Pilar Martínez-Martínez ◽  
Mario Losen ◽  
Yasin Temel ◽  
Thomas Steckler ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Delivery ◽  
In Vivo Electroporation ◽  
Targeted Gene Delivery ◽  
System A ◽  
The Central Nervous System

scholarly journals Pioneers in the cisterna magna puncture

2020 ◽  
Vol 78 (3) ◽  
pp. 176-178
Author(s):  
Thiago Ferreira Simões DE SOUZA
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Clinical Applications ◽  
Alternative Route ◽  
Cisterna Magna ◽  
Relative Safety ◽  
The Central Nervous System ◽  
Promising Source ◽  
Diagnosis Of Diseases

Abstract At the beginning of the 20th century, cerebrospinal fluid (CSF) collection and analysis emerged as a promising aid in the diagnosis of diseases of the central nervous system. It was obtained through the established procedure of lumbar puncture, described by Heinrich Quinke in 1891. The search for an alternative way to gather the CSF emerged in animal research, highlighting the cisterna magna as a promising source, with relative safety when performed by someone trained. Described initially and in detail by James Ayer in 1920, the procedure was widely adopted by neurologists and psychiatrists at the time, featuring its multiple advantages and clinical applications. After a period of great procedure use and exponential data collection, its complications and risks relegated the puncture of the cisterna magna as an alternative route that causes fear and fascination in modern Neurology.

A multicellular, neuro-mimetic model to study nanoparticle uptake in cells of the central nervous system

2014 ◽  
Vol 6 (9) ◽  
pp. 855-861 ◽  
Author(s):  
A. R. Fernandes ◽  
D. M. Chari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Gene Delivery ◽  
Neural Model ◽  
Cell Populations ◽  
Nanoparticle Uptake ◽  
System P ◽  
The Central Nervous System ◽  
In Cells

We describe a multicellular neural model to study nanoparticle uptake and gene delivery, using stem cell derived cell populations.

Nonviral Gene Delivery to the Central Nervous System Based on a Novel Integrin-Targeting Multifunctional Protein

2003 ◽  
Vol 14 (13) ◽  
pp. 1215-1223 ◽  
Author(s):  
H. Peluffo ◽  
A. Arís ◽  
L. Acarin ◽  
B. González ◽  
A. Villaverde ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Multifunctional Protein ◽  
The Central Nervous System

Herpes Simplex Virus as a Gene-Delivery Vector for the Central Nervous System

Viral Vectors ◽  
1995 ◽  
pp. 1-23 ◽  
Author(s):  
Joseph C. Glorioso ◽  
Mary Ann Bender ◽  
William F. Goins ◽  
Neal DeLuca ◽  
David J. Fink
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Delivery ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
The Central Nervous System ◽  
Simplex Virus
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