scholarly journals Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy

2009 ◽  
Vol 17 (12) ◽  
pp. 2058-2066 ◽  
Author(s):  
Chunxiao Wu ◽  
Jiakai Lin ◽  
Michelle Hong ◽  
Yukti Choudhury ◽  
Poonam Balani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Therapy ◽  
Suicide Gene ◽  
Tissue Specific ◽  
Microrna Regulation ◽  
Tissue Specific Promoter ◽  
Combinatorial Control

scholarly journals Targeted Expression of Suicide Gene by Tissue-Specific Promoter and MicroRNA Regulation for Cancer Gene Therapy

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83398 ◽  
Author(s):  
Ravikanth Danda ◽  
Gopinath Krishnan ◽  
Kalaivani Ganapathy ◽  
Uma Maheswari Krishnan ◽  
Khetan Vikas ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Suicide Gene ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Tissue Specific ◽  
Microrna Regulation ◽  
Tissue Specific Promoter ◽  
Targeted Expression

scholarly journals Highly controlled gene expression using combinations of a tissue-specific promoter, recombinant adenovirus and a tetracycline-regulatable transcription factor

Gene Therapy ◽  
1998 ◽  
Vol 5 (9) ◽  
pp. 1213-1220 ◽  
Author(s):  
P Ghersa ◽  
R Pescini Gobert ◽  
P Sattonnet-Roche ◽  
CA Richards ◽  
E Merlo Pich ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Recombinant Adenovirus ◽  
Tissue Specific ◽  
Tissue Specific Promoter

scholarly journals A mini review: RuBisCo small subunit as a strong, green tissue-specific promoter

2011 ◽  
Vol 63 (2) ◽  
pp. 299-307 ◽  
Author(s):  
Allah Bakhsh ◽  
Rao Qayyum ◽  
Zeeshan Shamim ◽  
Tayyab Husnain
Keyword(s):  
Gene Expression ◽  
Transgenic Plants ◽  
Genetic Engineering ◽  
Transgene Expression ◽  
Small Subunit ◽  
Tissue Specific ◽  
Rubisco Small Subunit ◽  
Green Tissue ◽  
Study Gene Expression ◽  
Tissue Specific Promoter

Plant genetic transformation is a powerful application used to study gene expression in plants. Transcriptomics has the potential to rapidly increase our knowledge of spatial and temporal gene expression and lead to new promoters for research and development. The availability of a broad spectrum of promoters with the ability to regulate the temporal and spatial expression patterns of transgenes can increase the successful application of transgenic technology. A variety of promoters is necessary at all levels of genetic engineering in plants, from basic research, to the development of economically viable crops and plant commodities, it can address legitimate concerns raised about the safety and containment of transgenic plants in the environment. Compared with temporal- or spatial-specific expression of a toxin, constitutive expression of foreign proteins in transgenic plants can cause adverse effects. The constitutive overexpression of transgenes that interferes with normal processes in a plant underscores the need for refinement of transgene expression. The development of tissue-specific promoters to drive transgene expression has helped fulfill that need. Therefore, in certain circumstances it is desirable to use expression-specific promoters which only express the foreign gene in specific plant tissues or organs. This review highlights the uses and benefits reaped by the use of green tissue-specific promoter for the RuBisCo small subunit in different crops and systems and thus establishing a broad range of tissue-specific promoters. Such plant promoters that are activated precisely when and where they are needed would be ideal for genetic engineering strategies.

scholarly journals Novel strong tissue specific promoter for gene expression in human germ cells

2010 ◽  
Vol 10 (1) ◽  
pp. 58 ◽  
Author(s):  
Denis Kuzmin ◽  
Elena Gogvadze ◽  
Roman Kholodenko ◽  
Dawid P Grzela ◽  
Maxim Mityaev ◽  
...  
Keyword(s):  
Gene Expression ◽  
Germ Cells ◽  
Tissue Specific ◽  
Tissue Specific Promoter
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