scholarly journals Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice

2017 ◽  
Vol 23 (8) ◽  
pp. 1717-1730 ◽  
Author(s):  
R Shinohara ◽  
M Taniguchi ◽  
A T Ehrlich ◽  
K Yokogawa ◽  
Y Deguchi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Dendritic Growth ◽  
Acute Stress ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Subtype ◽  
Excitatory Neurons ◽  
Stress Susceptibility

scholarly journals Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chisato Numa ◽  
Hirotaka Nagai ◽  
Masayuki Taniguchi ◽  
Midori Nagai ◽  
Ryota Shinohara ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Anterior Commissure ◽  
Social Defeat ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Social Defeat Stress ◽  
Brain Areas ◽  
Extended Amygdala ◽  
Fos Expression

Abstract We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mPFC) is activated by subthreshold social defeat stress and suppresses the induction of depressive-like behavior in mice. However, which mPFC projection(s) mediates this antidepressant-like effect remains poorly understood. Here we show that social defeat stress specifically increased c-Fos expression, a marker for neuronal activity, in distinct brain regions involved in emotional regulation, relative to novelty-induced exploration. Among these brain areas, D1 knockdown in the mPFC decreased social defeat stress-induced c-Fos expression in the interstitial nucleus of the posterior limb of the anterior commissure (IPAC), a subregion of the extended amygdala. Using retrograde adeno-associated virus vectors and transgenic mice expressing Cre recombinase under the D1 promoter, we also found that D1-expressing deep-layer pyramidal neurons in the mPFC send direct projections to the IPAC. These findings indicate that social defeat stress specifically activates neurons in distinct brain areas, among which the IPAC is regulated by dopamine D1 receptor in the mPFC perhaps through direct projections. Thus, this study provides hints toward identifying neural circuits that underlie antidepressant-like effects of stress-induced dopamine D1 receptor signaling in the mPFC.

scholarly journals Perceived life stress exposure modulates reward-related medial prefrontal cortex responses to acute stress in depression

2015 ◽  
Vol 180 ◽  
pp. 104-111 ◽  
Author(s):  
Poornima Kumar ◽  
George M. Slavich ◽  
Lisa H. Berghorst ◽  
Michael T. Treadway ◽  
Nancy H. Brooks ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Life Stress ◽  
Acute Stress ◽  
Stress Exposure
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