Dopamine D1 receptor in the medial prefrontal cortex mediates anxiety-like behaviors induced by blocking glutamatergic activity of the ventral hippocampus in rats

2019 ◽  
Vol 1704 ◽  
pp. 59-67 ◽  
Author(s):  
Li Liu ◽  
Li Zhang ◽  
Tao Wang ◽  
Li Chen
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ventral Hippocampus ◽  
Dopamine D1 Receptor ◽  
D1 Receptor

scholarly journals Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chisato Numa ◽  
Hirotaka Nagai ◽  
Masayuki Taniguchi ◽  
Midori Nagai ◽  
Ryota Shinohara ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Anterior Commissure ◽  
Social Defeat ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Social Defeat Stress ◽  
Brain Areas ◽  
Extended Amygdala ◽  
Fos Expression

Abstract We recently reported that dopamine D1 receptor in the medial prefrontal cortex (mPFC) is activated by subthreshold social defeat stress and suppresses the induction of depressive-like behavior in mice. However, which mPFC projection(s) mediates this antidepressant-like effect remains poorly understood. Here we show that social defeat stress specifically increased c-Fos expression, a marker for neuronal activity, in distinct brain regions involved in emotional regulation, relative to novelty-induced exploration. Among these brain areas, D1 knockdown in the mPFC decreased social defeat stress-induced c-Fos expression in the interstitial nucleus of the posterior limb of the anterior commissure (IPAC), a subregion of the extended amygdala. Using retrograde adeno-associated virus vectors and transgenic mice expressing Cre recombinase under the D1 promoter, we also found that D1-expressing deep-layer pyramidal neurons in the mPFC send direct projections to the IPAC. These findings indicate that social defeat stress specifically activates neurons in distinct brain areas, among which the IPAC is regulated by dopamine D1 receptor in the mPFC perhaps through direct projections. Thus, this study provides hints toward identifying neural circuits that underlie antidepressant-like effects of stress-induced dopamine D1 receptor signaling in the mPFC.

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