scholarly journals GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia

2017 ◽  
Vol 23 (6) ◽  
pp. 1496-1505 ◽  
Author(s):  
R Tao ◽  
K N Davis ◽  
C Li ◽  
J H Shin ◽  
Y Gao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Prefrontal Cortex ◽  
Brain Development ◽  
Alternative Transcripts

scholarly journals DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

2012 ◽  
Vol 91 (4) ◽  
pp. 765 ◽  
Author(s):  
Shusuke Numata ◽  
Tianzhang Ye ◽  
Thomas M. Hyde ◽  
Xavier Guitart-Navarro ◽  
Ran Tao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Prefrontal Cortex ◽  
Development And Aging

scholarly journals Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Lanyu Zhang ◽  
Tiago C. Silva ◽  
Juan I. Young ◽  
Lissette Gomez ◽  
Michael A. Schmidt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Methylation ◽  
Prefrontal Cortex ◽  
Biomarker Discovery ◽  
Meta Analysis ◽  
Enrichment Analysis ◽  
Braak Stage ◽  
Polycomb Repressive Complex 2 ◽  
Differentially Methylated Genes

AbstractDNA methylation differences in Alzheimer’s disease (AD) have been reported. Here, we conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize the most consistent methylation differences in multiple cohorts. Using a uniform analysis pipeline, we identified 3751 CpGs and 119 differentially methylated regions (DMRs) significantly associated with Braak stage. Our analysis identified differentially methylated genes such as MAMSTR, AGAP2, and AZU1. The most significant DMR identified is located on the MAMSTR gene, which encodes a cofactor that stimulates MEF2C. Notably, MEF2C cooperates with another transcription factor, PU.1, a central hub in the AD gene network. Our enrichment analysis highlighted the potential roles of the immune system and polycomb repressive complex 2 in pathological AD. These results may help facilitate future mechanistic and biomarker discovery studies in AD.

Stress regulates glucocorticoid-responsive genes expression in prefrontal cortex by altering DNA methylation: implication for lurasidone treatment

2019 ◽  
Vol 107 ◽  
pp. 12
Author(s):  
Paola Brivio ◽  
Giulia Sbrini ◽  
Letizia Tarantini ◽  
Chiara Favero ◽  
Mariusz Papp ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Prefrontal Cortex ◽  
Genes Expression

scholarly journals Mammalian Brain Development is Accompanied by a Dramatic Increase in Bipolar DNA Methylation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ming-an Sun ◽  
Zhixiong Sun ◽  
Xiaowei Wu ◽  
Veena Rajaram ◽  
David Keimig ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Brain Development ◽  
Mammalian Brain
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