scholarly journals What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit

2014 ◽  
Vol 19 (10) ◽  
pp. 1060-1070 ◽  
Author(s):  
C Barkus ◽  
D J Sanderson ◽  
J N P Rawlins ◽  
M E Walton ◽  
P J Harrison ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Subunit ◽  
Short Term ◽  
Ampa Receptor Subunit ◽  
Aberrant Salience

scholarly journals Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice

2011 ◽  
Vol 224 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Amy M. Taylor ◽  
Burkhard Niewoehner ◽  
Peter H. Seeburg ◽  
Rolf Sprengel ◽  
J. Nicholas P. Rawlins ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Knockout Mice ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Ampa Receptor Subunit

scholarly journals Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory

2011 ◽  
Vol 18 (3) ◽  
pp. 128-131 ◽  
Author(s):  
D. J. Sanderson ◽  
R. Sprengel ◽  
P. H. Seeburg ◽  
D. M. Bannerman
Keyword(s):  
Ampa Receptor ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Ampa Receptor Subunit

scholarly journals Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model

2009 ◽  
Vol 16 (6) ◽  
pp. 379-386 ◽  
Author(s):  
D. J. Sanderson ◽  
M. A. Good ◽  
K. Skelton ◽  
R. Sprengel ◽  
P. H. Seeburg ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Ampa Receptor ◽  
Knockout Mice ◽  
Dual Process ◽  
Memory Model ◽  
Receptor Subunit ◽  
Short Term ◽  
Process Memory ◽  
Ampa Receptor Subunit

scholarly journals Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus

2010 ◽  
Vol 30 (50) ◽  
pp. 16949-16958 ◽  
Author(s):  
M. V. Schmidt ◽  
D. Trumbach ◽  
P. Weber ◽  
K. Wagner ◽  
S. H. Scharf ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Stress Vulnerability ◽  
Ampa Receptor Subunit

scholarly journals Dissociating Representations of Time and Number in Reinforcement-Rate Learning by Deletion of the GluA1 AMPA Receptor Subunit in Mice

2021 ◽  
Vol 32 (2) ◽  
pp. 204-217
Author(s):  
Joseph M. Austen ◽  
Corran Pickering ◽  
Rolf Sprengel ◽  
David J. Sanderson
Keyword(s):  
Associative Strength ◽  
Ampa Receptor ◽  
Reinforcement Rate ◽  
Statistical Properties ◽  
Temporal Information ◽  
Receptor Subunit ◽  
Male And Female ◽  
Female Mice ◽  
Ampa Receptor Subunit ◽  
Numeric Information

Theories of learning differ in whether they assume that learning reflects the strength of an association between memories or symbolic encoding of the statistical properties of events. We provide novel evidence for symbolic encoding of informational variables by demonstrating that sensitivity to time and number in learning is dissociable. Whereas responding in normal mice was dependent on reinforcement rate, responding in mice that lacked the GluA1 AMPA receptor subunit was insensitive to reinforcement rate and, instead, dependent on the number of times a cue had been paired with reinforcement. This suggests that GluA1 is necessary for weighting numeric information by temporal information in order to calculate reinforcement rate. Sample sizes per genotype varied between seven and 23 across six experiments and consisted of both male and female mice. The results provide evidence for explicit encoding of variables by animals rather than implicit encoding via variations in associative strength.

Sign in / Sign up

Export Citation Format

Share Document