scholarly journals Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice

2011 ◽  
Vol 224 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Amy M. Taylor ◽  
Burkhard Niewoehner ◽  
Peter H. Seeburg ◽  
Rolf Sprengel ◽  
J. Nicholas P. Rawlins ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Knockout Mice ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Ampa Receptor Subunit

scholarly journals Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory

2011 ◽  
Vol 18 (3) ◽  
pp. 128-131 ◽  
Author(s):  
D. J. Sanderson ◽  
R. Sprengel ◽  
P. H. Seeburg ◽  
D. M. Bannerman
Keyword(s):  
Ampa Receptor ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Ampa Receptor Subunit

scholarly journals Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus

2010 ◽  
Vol 30 (50) ◽  
pp. 16949-16958 ◽  
Author(s):  
M. V. Schmidt ◽  
D. Trumbach ◽  
P. Weber ◽  
K. Wagner ◽  
S. H. Scharf ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Short Term Memory ◽  
Receptor Subunit ◽  
Short Term ◽  
Term Memory ◽  
Stress Vulnerability ◽  
Ampa Receptor Subunit

scholarly journals Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model

2009 ◽  
Vol 16 (6) ◽  
pp. 379-386 ◽  
Author(s):  
D. J. Sanderson ◽  
M. A. Good ◽  
K. Skelton ◽  
R. Sprengel ◽  
P. H. Seeburg ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Ampa Receptor ◽  
Knockout Mice ◽  
Dual Process ◽  
Memory Model ◽  
Receptor Subunit ◽  
Short Term ◽  
Process Memory ◽  
Ampa Receptor Subunit

scholarly journals Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4

2008 ◽  
Vol 17 (12) ◽  
pp. 1738-1749 ◽  
Author(s):  
Barbara Beyer ◽  
Charlotte Deleuze ◽  
Verity A. Letts ◽  
Connie L. Mahaffey ◽  
Rebecca M. Boumil ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Knockout Mice ◽  
Receptor Subunit ◽  
Absence Seizures ◽  
Ampa Receptor Subunit

scholarly journals Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory

2020 ◽  
Author(s):  
Maria Gomis-González ◽  
Lorena Galera-López ◽  
Marc Ten-Blanco ◽  
Arnau Busquets-Garcia ◽  
Thomas Cox ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Knockout Mice ◽  
Short Term Memory ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Kinase C ◽  
Protein Kinase C Gamma

scholarly journals Sevoflurane Impairs Short-Term Memory by Affecting PSD-95 and AMPA Receptor in the Hippocampus of a Mouse Model

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Yuan Jiao ◽  
Hongwu Fan ◽  
Kexin Wang ◽  
Shan Lu
Keyword(s):  
Synaptic Transmission ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Short Term Memory ◽  
Receptor Expression ◽  
Expression Level ◽  
Short Term ◽  
Term Memory ◽  
Adult Mice ◽  
T1 And T2

Objective. To explore the effects of sevoflurane on the latency and error times of the passive avoidance and levels of PSD-95 and AMPA receptors in the hippocampus. We evaluated the effects of sevoflurane on short-term memory in adult mice and explored the possible mechanism. Methods. 144 Kunming mice (2-3 months, 30-35 g) were randomly divided into two groups A (n=64) and B (n=80) and received the dark-avoidance (DA) and step-down avoidance (SA) tests, respectively. The groups DA and SA were further divided into control (inhaled 40% O2 2 h) and sevoflurane (3.3% sevoflurane and 40% O2 2 h) subgroups. Before inhalation intervention, all mice were trained to be familiar with the Morris water maze (MWM). According to the test points of behavioral indicators, 8 mice were randomly selected from each subgroup at point 12 h (T1), 24 h (T2), 48 h (T3), and 72 h (T4) after inhalation intervention. The step-through latency and error times were measured in 5 min. After the behavioral test, the mice were killed and the tissues of the hippocampus were taken for hematoxylin and eosin (H&E) staining. The expression level of PSD-95 and AMPA receptors in the hippocampus was detected by immunohistochemistry and Western Blot. The changes of synaptic transmission were measured via electrophysiology analysis of hippocampal slices. Results. The mice in the control subgroups found the platform in a shorter pathway than those in the sevoflurane subgroups during an MWM test. The step-through latency of T1 and T2 in the sevoflurane subgroup was shorter than baseline time, and the error times were increased in 5 min and higher than baseline time when compared with the control subgroup (P<0.05) in the A and B groups. Compared with the control subgroup, the expression level of PSD-95 and AMPA receptors in the hippocampus was decreased at T1 and T2 in the sevoflurane subgroup (P<0.05). The nerve cells were partially swelling. Electrophysiology analysis showed that the levels of PSD-95 and AMPA receptor expression were associated with synaptic transmission. Conclusion. Sevoflurane impaired short-term memory in adult mice by inhibiting the expression of PSD-95 and AMPA receptors in the hippocampus, which led to the decrease in synaptic transmission.

scholarly journals What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit

2014 ◽  
Vol 19 (10) ◽  
pp. 1060-1070 ◽  
Author(s):  
C Barkus ◽  
D J Sanderson ◽  
J N P Rawlins ◽  
M E Walton ◽  
P J Harrison ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Subunit ◽  
Short Term ◽  
Ampa Receptor Subunit ◽  
Aberrant Salience

AMPA receptor subunit 1 (GluR‐A) knockout mice model the glutamate hypothesis of depression

2008 ◽  
Vol 22 (9) ◽  
pp. 3129-3134 ◽  
Author(s):  
S. Chourbaji ◽  
M. A. Vogt ◽  
F. Fumagalli ◽  
R. Sohr ◽  
A. Frasca ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Knockout Mice ◽  
Receptor Subunit ◽  
Mice Model ◽  
Ampa Receptor Subunit
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