scholarly journals Recovery and Expression of Messenger RNA from Postmortem Human Brain Tissue

2001 ◽  
Vol 14 (11) ◽  
pp. 1157-1161 ◽  
Author(s):  
Thomas J Cummings ◽  
Jay C Strum ◽  
Lawrence W Yoon ◽  
Mari H Szymanski ◽  
Christine M Hulette
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Messenger Rna ◽  
Human Brain Tissue ◽  
Postmortem Human Brain

Characterization of miRNA Isoform Expression In Schizophrenia Using Postmortem Human Brain Tissue

2019 ◽  
Vol 29 ◽  
pp. S720
Author(s):  
Carrie Wright ◽  
Joo Heon Shin ◽  
Anandita Rajpurohit ◽  
Courtney Williams ◽  
Andrew Jaffe ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Human Brain Tissue ◽  
Postmortem Human Brain ◽  
Isoform Expression

scholarly journals DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan

2020 ◽  
Vol 7 (1) ◽  
pp. e537
Author(s):  
Kathleen E. Langbehn ◽  
Zoe Carlson-Stadler ◽  
Ellen van der Plas ◽  
Marco M. Hefti ◽  
Jeffrey D. Dawson ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Brain Tissue ◽  
Myotonic Dystrophy ◽  
Messenger Rna ◽  
Trinucleotide Repeat ◽  
Expression Patterns ◽  
Data Sets ◽  
Linear Regression Models ◽  
Human Brain Tissue

ObjectiveMyotonic dystrophy is a multisystem disorder caused by a trinucleotide repeat expansion on the myotonic dystrophy protein kinase (DMPK) gene. To determine whether wildtype DMPK expression patterns vary as a function of age, we analyzed DMPK expression in the brain from 99 donors ranging from 5 postconceptional weeks to 80 years old.MethodsWe used the BrainSpan messenger RNA sequencing and the Yale Microarray data sets, which included brain tissue samples from 42 and 57 donors, respectively. Collectively, donors ranged in age from 5 postconceptional weeks to 80 years old. DMPK expression was normalized for each donor across regions available in both data sets. Restricted cubic spline linear regression models were used to analyze the effects of log-transformed age and sex on normalized DMPK expression data.ResultsAge was a statistically significant predictor of normalized DMPK expression pattern in the human brain in the BrainSpan (p < 0.005) and Yale data sets (p < 0.005). Sex was not a significant predictor. Across both data sets, normalized wildtype DMPK expression steadily increases during fetal development, peaks around birth, and then declines to reach a nadir around age 10.ConclusionsPeak expression of DMPK coincides with a time of dynamic brain development. Abnormal brain DMPK expression due to myotonic dystrophy may have implications for early brain development.

scholarly journals Investigating Aβ plaque development using FTIR micro‐spectroscopy on native postmortem human brain tissue

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Dominik Röhr ◽  
Baayla D.C. Boon ◽  
Frederik Großerüschkamp ◽  
Femke Bouwman ◽  
Jeroen J.M. Hoozemans ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Human Brain Tissue ◽  
Postmortem Human Brain ◽  
Plaque Development

Protein Kinase Activity Profiling of Postmortem Human Brain Tissue

2012 ◽  
Vol 10 (1-4) ◽  
pp. 46-48 ◽  
Author(s):  
Jeroen J.M. Hoozemans ◽  
Riet Hilhorst ◽  
Rob Ruijtenbeek ◽  
Annemieke J.M. Rozemuller ◽  
Saskia M. van der Vies
Keyword(s):  
Protein Kinase ◽  
Human Brain ◽  
Brain Tissue ◽  
Kinase Activity ◽  
Protein Kinase Activity ◽  
Human Brain Tissue ◽  
Postmortem Human Brain ◽  
Activity Profiling

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue

1999 ◽  
Vol 97 (4) ◽  
pp. 383-392 ◽  
Author(s):  
Margit Overmyer ◽  
Seppo Helisalmi ◽  
Hilkka Soininen ◽  
Markku Laakso ◽  
Paavo Riekkinen Sr. ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Immunohistochemical Study ◽  
Human Brain Tissue ◽  
Postmortem Human Brain ◽  
Reactive Microglia

Distribution of Venlafaxine,O-desmethylvenlafaxine, andO-desmethylvenlafaxine to Venlafaxine Ratio in Postmortem Human Brain Tissue

2014 ◽  
Vol 59 (3) ◽  
pp. 683-689 ◽  
Author(s):  
Meredith D. Murrell ◽  
Dianne A. Cruz ◽  
Martin A. Javors ◽  
Peter M. Thompson
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Human Brain Tissue ◽  
Postmortem Human Brain

scholarly journals Comparison of Reference Genes for Transcriptional Studies in Postmortem Human Brain Tissue Under Different Conditions

2018 ◽  
Vol 35 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Qing Zhang ◽  
Hanlin Zhang ◽  
Fan Liu ◽  
Qian Yang ◽  
Kang Chen ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Reference Genes ◽  
Human Brain Tissue ◽  
Postmortem Human Brain
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