scholarly journals Caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or Epstein–Barr virus

2005 ◽  
Vol 18 (6) ◽  
pp. 822-827 ◽  
Author(s):  
Pao-Hsien Chu ◽  
Shih-Ming Jung ◽  
Hsin-Chiung Lin ◽  
Chi-Hsiao Yeh ◽  
Hsueh-Hua Wu ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Epstein Barr Virus ◽  
Caspase 3 ◽  
Cardiac Myxoma ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Presence of Human Papillomavirus and Epstein–Barr Virus, but Absence of Merkel Cell Polyomavirus, in Head and Neck Cancer of Non-Smokers and Non-Drinkers

2021 ◽  
Vol 10 ◽  
Author(s):  
Frans J. Mulder ◽  
Faisal Klufah ◽  
Famke M. E. Janssen ◽  
Farzaneh Farshadpour ◽  
Stefan M. Willems ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Epstein Barr Virus ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
Cell Cycle Proteins ◽  
P53 Expression ◽  
Barr Virus ◽  
Epstein Barr

ObjectiveDetermine the presence and prognostic value of human papillomavirus (HPV), Epstein-Barr virus (EBV), Merkel cell polyomavirus (MCPyV), and cell cycle proteins in head and neck squamous cell carcinoma (HNSCC) of non-smokers and non-drinkers (NSND).MethodsClinical characteristics and tumors of 119 NSND with HNSCC were retrospectively collected and analyzed on tissue microarrays. RNAscope in situ hybridization (ISH) was used to screen for the presence of HPV and MCPyV mRNA. Immunohistochemistry was performed for expression of p16 as surrogate marker for HPV, Large T-antigen for MCPyV, and cell cycle proteins p53 and pRb. Positive virus results were confirmed with polymerase chain reaction. For EBV, EBV encoded RNA ISH was performed. Differences in 5-year survival between virus positive and negative tumors were determined by log rank analysis.ResultsAll oropharyngeal tumors (OPSCC) (n = 10) were HPV-positive, in addition to one oral (OSCC) and one nasopharyngeal tumor (NPSCC). The other three NPSCC were EBV-positive. MCPyV was not detected. Patients with HPV or EBV positive tumors did not have a significantly better 5-year disease free or overall survival. Over 70% of virus negative OSCC showed mutant-type p53 expression.ConclusionIn this cohort, all OPSCC and NPSCC showed HPV or EBV presence. Besides one OSCC, all other oral (n = 94), hypopharyngeal (n = 1), and laryngeal (n = 9) tumors were HPV, EBV, and MCPyV negative. This argues against a central role of these viruses in the ethiopathogenesis of tumors outside the oro- and nasopharynx in NSND. So, for the majority of NSND with virus negative OSCC, more research is needed to understand the carcinogenic mechanisms in order to consider targeted therapeutic options.

scholarly journals Epstein‐Barr virus and human papillomavirus serum antibodies define the viral status of nasopharyngeal carcinoma in a low endemic country

2020 ◽  
Vol 147 (2) ◽  
pp. 461-471 ◽  
Author(s):  
Julia Simon ◽  
Lea Schroeder ◽  
Kate Ingarfield ◽  
Stefan Diehl ◽  
Jill Werner ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Endemic Country ◽  
Serum Antibodies ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals 18F-FDG PET/CTvs. human papillomavirus, p16 and Epstein-Barr virus detection in cervical metastatic lymph nodes for identifying primary tumors

2017 ◽  
Vol 140 (6) ◽  
pp. 1405-1412 ◽  
Author(s):  
Gi Cheol Park ◽  
Jong-Lyel Roh ◽  
Kyung-Ja Cho ◽  
Jae Seung Kim ◽  
Mi Hyeon Jin ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Lymph Nodes ◽  
Fdg Pet ◽  
Epstein Barr Virus ◽  
Virus Detection ◽  
Primary Tumors ◽  
Metastatic Lymph Nodes ◽  
Barr Virus ◽  
18F Fdg ◽  
Epstein Barr
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