scholarly journals 18F-FDG PET/CTvs. human papillomavirus, p16 and Epstein-Barr virus detection in cervical metastatic lymph nodes for identifying primary tumors

2017 ◽  
Vol 140 (6) ◽  
pp. 1405-1412 ◽  
Author(s):  
Gi Cheol Park ◽  
Jong-Lyel Roh ◽  
Kyung-Ja Cho ◽  
Jae Seung Kim ◽  
Mi Hyeon Jin ◽  
...  
1998 ◽  
Vol 14 (2) ◽  
pp. 113-120 ◽  
Author(s):  
S. K. Kassim ◽  
S. A. Ibrahim ◽  
S. Eissa ◽  
S. S. A. Zaki ◽  
M. A. El-Begermy ◽  
...  

It is widely accepted that the Epstein-Barr virus is etiologically associated with the development of nasopharyngeal carcinoma. The human papillomavirus is also associated with inverted papilloma. We used the polymerase chain reaction technique to detect both viruses in both types of tumors. Flow cytometry was also used to study the DNA pattern and proliferative behavior of the tumors in relation to the viruses. EBV was detected in 13/20 (65%) of NPC specimens, and in none of IP (n= 10) or control specimens (n= 10). This indicates the contribution of EBV as an etiologic factor in NPC. Five cases of NPC (25%) were positive for HPV 16, two of them were EBV positive. Four HPV 16 positive cases were found among cases with inverted papilloma, but none among the control cases. Flow cytometry revealed that all NPC, IP, and control samples were diploid except one aneuploid NPC sample. Proliferative capacity (PC) of primary tumors was predictive of tumor recurrence in NPC. Using 13.6% as a cut-off point for PC, we were able to discriminate between high risk and low risk groups with 100% sensitivity and 86% specificity. PC can be used as a baseline prognostic parameter in NPC, making it possible to modify courses of treatment in an attempt to inhibit tumor recurrence.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hitomi Kawamura ◽  
Sho Koyasu ◽  
Akihiko Sugimoto ◽  
Yuji Nakamoto

2017 ◽  
Vol 42 (8) ◽  
pp. 645-646 ◽  
Author(s):  
Anna Margherita Maffione ◽  
Lucia Rampin ◽  
Rossella Paolini ◽  
Elisabetta Rodella ◽  
Laura Camilla Lisato ◽  
...  

Diagnostics ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 18 ◽  
Author(s):  
Mathilde Ørbæk ◽  
Jesper Graff ◽  
Elena Markova ◽  
Gitte Kronborg ◽  
Anne-Mette Lebech

2012 ◽  
Vol 53 (1) ◽  
pp. 21-28 ◽  
Author(s):  
K.-P. Chang ◽  
N.-M. Tsang ◽  
C.-T. Liao ◽  
C.-L. Hsu ◽  
M.-J. Chung ◽  
...  

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