scholarly journals Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly

2003 ◽  
Vol 17 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Tomio Arai ◽  
Yukiyoshi Esaki ◽  
Motoji Sawabe ◽  
Naoko Honma ◽  
Ken-ichi Nakamura ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
The Elderly ◽  
Poorly Differentiated

scholarly journals TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma

1997 ◽  
Vol 75 (11) ◽  
pp. 1678-1683 ◽  
Author(s):  
DG Powe ◽  
JL Brough ◽  
GI Carter ◽  
EM Bailey ◽  
WG Stetler-Stevenson ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Colorectal Adenocarcinoma ◽  
Poorly Differentiated

scholarly journals Clinicopathological Study of Poorly Differentiated Colorectal Adenocarcinoma.

1992 ◽  
Vol 45 (2) ◽  
pp. 244-247 ◽  
Author(s):  
M. Kanno ◽  
H. Sakamoto ◽  
Y. Tsukioka ◽  
Y. Takano ◽  
Y. Kurosaka ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Study ◽  
Poorly Differentiated

scholarly journals Higher Expression of Epidermal Growth Factor Receptor Is Associated with Extracellular Matrix Metalloprotease Inducer in Colorectal Adenocarcinoma: Tissue Microarray Analysis of Immunostaining Score with Clinicopathological Parameters

2006 ◽  
Vol 22 (5-6) ◽  
pp. 309-316 ◽  
Author(s):  
Jong-Shiaw Jin ◽  
Chi-Ying Wu ◽  
Yeh-Feng Lin ◽  
Jia-Yi Wang ◽  
Cheng-Ping Yu ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Growth Factor Receptor ◽  
Clinicopathological Parameters ◽  
Colorectal Cancers ◽  
Matrix Metalloprotease ◽  
Egfr Expression ◽  
Poorly Differentiated ◽  
Epidermal Growth ◽  
Well Differentiated ◽  
Colorectal Adenocarcinomas

Aim: Extracellular matrix metalloprotease inducer (EMMPRIN) expression was demonstrated in several cancers, but its expression profile in colorectal cancers remains unclear. Epidermal growth factor receptor (EGFR) was reported to regulate EMMPRIN expression in human epithelial cancers. Our purpose was to determine EMMPRIN expression and its relationship with EGFR in colorectal cancers.Methods: Immunohistochemical analysis of EMMPRIN and EGFR was performed in tissue microarray slides of 90 surgical specimens including 32 well differentiated, 35 moderately differentiated, and 23 poorly differentiated colorectal adenocarcinomas.Results: All colorectal adenocarcinomas showed significant immunohistochemical expression of EMMPRIN. The EMMPRIN scores in poorly differentiated (303 ± 21) and moderately differentiated (326 ± 17) colorectal adenocarcinoma were significantly higher than in well differentiated (166 ± 20) colorectal adenocarcinoma. EGFR expression was mainly on the cell surface of tumor cells and the immunostaining scores of EGFR were significantly associated with the advanced clinical T and N stages. A significantly positive relationship between EMMPRIN and EGFR immunostaining scores was also noted.Conclusions: Increased expression of EMMPRIN and EGFR in colorectal adenocarcinomas is associated with clinicopathological parameters of advanced colorectal adenocarcinoma stages.In addition, the data from this study support the notion that EGFR expression may up-regulate EMMPRIN expression.

scholarly journals Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Rodney E. Shackelford ◽  
Pushpa Allam-Nandyala ◽  
Marilyn M. Bui ◽  
John V. Kiluk ◽  
Nicole Nicosia Esposito
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Colorectal Adenocarcinoma ◽  
Medical Literature ◽  
Rare Event ◽  
Poorly Differentiated ◽  
Disseminated Disease ◽  
Breast Malignancies

Metastases to the breast from extramammary primaries are uncommon and account for 0.5–6% of all breast malignancies (Georgiannos et al., 2001, and Vizcaíno et al., 2001). Malignant melanoma, lymphoma, and lung and gastric carcinomas are the most frequently encountered nonmammary metastases to the breast in adults (Georgiannos et al., 2001, and Chaignaud et al., 1994). Primary colorectal adenocarcinoma (CRC) metastatic to the breast is extremely rare, with the medical literature having only 19 recorded cases. Typically CRC metastatic to the breast is indicative of widely disseminated disease and a poor prognosis. Here we present a case of poorly differentiated colon cancer metastatic to the breast and review the current literature on this rare event.

scholarly journals Synchronous Primary Anorectal Melanoma and Sigmoid Adenocarcinoma: A Case Report

2015 ◽  
Vol 100 (5) ◽  
pp. 814-817 ◽  
Author(s):  
Aaron Lim ◽  
Benjamin Grant ◽  
John Avramovic ◽  
Yik-Hong Ho ◽  
Corrine Wallace
Keyword(s):  
Abdominoperineal Resection ◽  
Colorectal Adenocarcinoma ◽  
Anal Verge ◽  
White Male ◽  
Treatment Modalities ◽  
Anorectal Melanoma ◽  
Polypoid Mass ◽  
Synchronous Cancers ◽  
Poorly Differentiated ◽  
Colorectal Surgeons

Synchronous primary anorectal melanoma and colorectal adenocarcinoma is extremely rare, with only 5 cases reported in the literature. Here, a case is reported and the currently available literature is summarized. A 72-year-old white male presented with changes in his bowel habits and unintentional weight loss. Colonoscopy revealed a polypoid mass in the distal rectum extending to the anal verge anteriorly and a circumferential polypoid mass in the distal sigmoid colon. Biopsies were taken, which revealed poorly differentiated melanoma of the anorectal mass and moderately differentiated adenocarcinoma of the sigmoid mass with nodal involvement. Computed tomography of the abdomen showed liver metastasis. An extended abdominoperineal resection was undertaken for palliation, relief of symptoms, and definitive histology to guide further management. Consequently, a resection of the hepatic metastasis was attempted; however, macroscopic deposits were discovered on 7 of 8 liver segments perioperatively. He was subsequently referred to medical oncology for palliative chemotherapy. Synchronous primary anorectal melanoma and colorectal adenocarcinoma is rare, this being the sixth report found in the literature. In summary of the available cases, all synchronous cancers were located in the rectosigmoid and had very similar presentations. Most presented relatively late and were generally treated with abdominoperineal resection, which appears to be the best treatment option. Overall, prognosis appears to be dismal. General and colorectal surgeons should always be aware of the possibilities of simultaneous primary cancers because this can affect treatment modalities and prognosis for the patient.

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