scholarly journals TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinoma

1997 ◽  
Vol 75 (11) ◽  
pp. 1678-1683 ◽  
Author(s):  
DG Powe ◽  
JL Brough ◽  
GI Carter ◽  
EM Bailey ◽  
WG Stetler-Stevenson ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Colorectal Adenocarcinoma ◽  
Poorly Differentiated

scholarly journals Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bokyung Ahn ◽  
Yang Seok Chae ◽  
Soo Kyung Lee ◽  
Moa Kim ◽  
Hyeon Soo Kim ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Cell Lines ◽  
Adenylate Kinase ◽  
Dna Methyltransferase ◽  
Colorectal Adenocarcinoma ◽  
Adenine Nucleotides ◽  
Inverse Correlation ◽  
Dna Hypermethylation ◽  
Normal Tissues ◽  
The Difference

AbstractAdenylate kinase 5 (AK5) belongs to the adenylate kinase family that catalyses reversible phosphate transfer between adenine nucleotides, and it is related to various energetic signalling mechanisms. However, the role of AK5 in colorectal cancer (CRC) has not been reported. In this study, AK5 was significantly hypermethylated in CRC compared to adjacent normal tissues (P < 0.0001) and normal tissues (P = 0.0015). Although the difference in mRNA expression was not statistically significant in all of them, the selected 49 cases of CRC tissues with AK5 hypermethylation with the cut off value of 40% showed a significant inverse correlation with mRNA expression (P = 0.0003). DNA methylation of AK5 promoter significantly decreased and AK5 expression recovered by 5-aza-2′-deoxycytidine, DNA methyltransferase inhibitor in CRC cell lines. In addition, AK5 promoter activity significantly decreased due to DNA methyltransferase, and it increased due to 5-aza. Moreover, AK5 regulated the phosphorylated AMPK and mTOR phosphorylation and inhibited the cell migration and cell invasion in CRC cell lines. Furthermore, low AK5 expression is associated with poor differentiation (P = 0.014). These results demonstrate that the AK5 promoter is frequently hypermethylated and induced methylation-mediated gene down-regulation. AK5 expression regulates AMPK/mTOR signalling and may be closely related to metastasis in colorectal adenocarcinoma.

mRNA Expression of IGF-1 and IGF-1R in Patients with Colorectal Adenocarcinoma and Type 2 Diabetes

2014 ◽  
Vol 45 (4) ◽  
pp. 318-324 ◽  
Author(s):  
Rui Liu ◽  
Li-Ling Hu ◽  
Ao Sun ◽  
Ya-Jing Cao ◽  
Tao Tang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mrna Expression ◽  
Colorectal Adenocarcinoma

scholarly journals Clinicopathological Study of Poorly Differentiated Colorectal Adenocarcinoma.

1992 ◽  
Vol 45 (2) ◽  
pp. 244-247 ◽  
Author(s):  
M. Kanno ◽  
H. Sakamoto ◽  
Y. Tsukioka ◽  
Y. Takano ◽  
Y. Kurosaka ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Study ◽  
Poorly Differentiated

scholarly journals Higher Expression of Epidermal Growth Factor Receptor Is Associated with Extracellular Matrix Metalloprotease Inducer in Colorectal Adenocarcinoma: Tissue Microarray Analysis of Immunostaining Score with Clinicopathological Parameters

2006 ◽  
Vol 22 (5-6) ◽  
pp. 309-316 ◽  
Author(s):  
Jong-Shiaw Jin ◽  
Chi-Ying Wu ◽  
Yeh-Feng Lin ◽  
Jia-Yi Wang ◽  
Cheng-Ping Yu ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Growth Factor Receptor ◽  
Clinicopathological Parameters ◽  
Colorectal Cancers ◽  
Matrix Metalloprotease ◽  
Egfr Expression ◽  
Poorly Differentiated ◽  
Epidermal Growth ◽  
Well Differentiated ◽  
Colorectal Adenocarcinomas

Aim: Extracellular matrix metalloprotease inducer (EMMPRIN) expression was demonstrated in several cancers, but its expression profile in colorectal cancers remains unclear. Epidermal growth factor receptor (EGFR) was reported to regulate EMMPRIN expression in human epithelial cancers. Our purpose was to determine EMMPRIN expression and its relationship with EGFR in colorectal cancers.Methods: Immunohistochemical analysis of EMMPRIN and EGFR was performed in tissue microarray slides of 90 surgical specimens including 32 well differentiated, 35 moderately differentiated, and 23 poorly differentiated colorectal adenocarcinomas.Results: All colorectal adenocarcinomas showed significant immunohistochemical expression of EMMPRIN. The EMMPRIN scores in poorly differentiated (303 ± 21) and moderately differentiated (326 ± 17) colorectal adenocarcinoma were significantly higher than in well differentiated (166 ± 20) colorectal adenocarcinoma. EGFR expression was mainly on the cell surface of tumor cells and the immunostaining scores of EGFR were significantly associated with the advanced clinical T and N stages. A significantly positive relationship between EMMPRIN and EGFR immunostaining scores was also noted.Conclusions: Increased expression of EMMPRIN and EGFR in colorectal adenocarcinomas is associated with clinicopathological parameters of advanced colorectal adenocarcinoma stages.In addition, the data from this study support the notion that EGFR expression may up-regulate EMMPRIN expression.

scholarly journals Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly

2003 ◽  
Vol 17 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Tomio Arai ◽  
Yukiyoshi Esaki ◽  
Motoji Sawabe ◽  
Naoko Honma ◽  
Ken-ichi Nakamura ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
The Elderly ◽  
Poorly Differentiated

scholarly journals SELENOT–Knockdown Leads to Reducing the Expression of Key Enzymes of ERAD–System in Cancer Cells Under ER–Stress

2021 ◽  
Author(s):  
M. V. Goltyaev ◽  
E. V. Blinova ◽  
E. G. Varlamova
Keyword(s):  
Er Stress ◽  
Mrna Expression ◽  
Colorectal Adenocarcinoma ◽  
Human Cancer ◽  
Redox Homeostasis ◽  
Marker Genes ◽  
Human Cancer Cell Lines ◽  
Stress Markers ◽  
Methylseleninic Acid ◽  
Number Of Genes

Abstract SELENOT is one of the seven selenoproteins localized in the ER. The purpose of this work was to study the effect of SELENOT–knockdown on mRNA expression of a large number of genes (ER–stress markers, physiological partners of SELENOT, ER–resident selenoproteins, other selenoproteins) under conditions of ER–stress caused by both selenium–containing compounds (sodium selenite and methylseleninic acid) and non–selenium–containing compounds (dithiothriitol) by the example of two human cancer cell lines A–172 (human glioblastoma) and Caco–2 (human colorectal adenocarcinoma). In the course of this work, it was found that SELENOT–knockdown does not significantly affect viability and proliferative properties, redox homeostasis in A–172 and Caco–2 cells and the acquisition of signs of normal cells by them, does not significantly affect the expression of ER–stress marker genes, ER–resident selenoproteins, with the exception of DIO2 and SELENOM. But it has a significant effect on reducing the levels of mRNA expression of AMFR and RNF5 are important enzymes of the ERAD–system, disrupting its work and leading to the accumulation of proteins with incorrect folding, thereby only aggravating ER stress.

scholarly journals Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Rodney E. Shackelford ◽  
Pushpa Allam-Nandyala ◽  
Marilyn M. Bui ◽  
John V. Kiluk ◽  
Nicole Nicosia Esposito
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Colorectal Adenocarcinoma ◽  
Medical Literature ◽  
Rare Event ◽  
Poorly Differentiated ◽  
Disseminated Disease ◽  
Breast Malignancies

Metastases to the breast from extramammary primaries are uncommon and account for 0.5–6% of all breast malignancies (Georgiannos et al., 2001, and Vizcaíno et al., 2001). Malignant melanoma, lymphoma, and lung and gastric carcinomas are the most frequently encountered nonmammary metastases to the breast in adults (Georgiannos et al., 2001, and Chaignaud et al., 1994). Primary colorectal adenocarcinoma (CRC) metastatic to the breast is extremely rare, with the medical literature having only 19 recorded cases. Typically CRC metastatic to the breast is indicative of widely disseminated disease and a poor prognosis. Here we present a case of poorly differentiated colon cancer metastatic to the breast and review the current literature on this rare event.

Sign in / Sign up

Export Citation Format

Share Document