scholarly journals Autoimmune hepatitis: review of histologic features included in the simplified criteria proposed by the international autoimmune hepatitis group and proposal for new histologic criteria

2017 ◽  
Vol 30 (5) ◽  
pp. 773-783 ◽  
Author(s):  
Dana Balitzer ◽  
Nafis Shafizadeh ◽  
Marion G Peters ◽  
Linda D Ferrell ◽  
Najeeb Alshak ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
International Autoimmune Hepatitis Group

Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group

2004 ◽  
Vol 41 (4) ◽  
pp. 677-683 ◽  
Author(s):  
Diego Vergani ◽  
Fernando Alvarez ◽  
Francesco B. Bianchi ◽  
Eduardo L.R. Cançado ◽  
Ian R. Mackay ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Consensus Statement ◽  
International Autoimmune Hepatitis Group

Diagnostic Criteria for Autoimmune Hepatitis: Scores and More

2015 ◽  
Vol 33 (Suppl. 2) ◽  
pp. 47-52 ◽  
Author(s):  
Ansgar W. Lohse
Keyword(s):  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Diagnostic Criteria ◽  
Clinical Use ◽  
Serological Markers ◽  
Diagnostic Score ◽  
Different Populations ◽  
International Autoimmune Hepatitis Group ◽  
Patient’S History ◽  
Diagnostic Scores

The diagnosis of autoimmune hepatitis is a clinical diagnosis that combines the patient's history, clinical examination, laboratory and serological markers and the results of a liver biopsy. As the clinical spectrum of autoimmune hepatitis is very wide, making the diagnosis can sometimes be difficult, especially in non-expert hands. Diagnostic scores can help in making the diagnosis, and the simplified diagnostic score of the International Autoimmune Hepatitis Group has a sensitivity and specificity of around 90% in the different populations that have been studied. Therefore, it can be very helpful in everyday use, but nonetheless for some patients the score is not good enough. Limitations are patients with very acute presentations as well as atypical cases. In such cases, a trial of monotherapy with steroids and quick tapering of the steroids is recommended. If the disease responds well to treatment, but recurs after tapering the steroids, the diagnosis of autoimmune hepatitis is confirmed. In addition to its clinical use, diagnostic scores can also be helpful in defining the unified criteria in order to make scientific studies comparable.

scholarly journals Autoimmune Hepatitis: Serum Autoantibodies in Clinical Practice

2021 ◽  
Author(s):  
Benedetta Terziroli Beretta-Piccoli ◽  
Giorgina Mieli-Vergani ◽  
Diego Vergani
Keyword(s):  
Autoimmune Hepatitis ◽  
Current Knowledge ◽  
Reference Method ◽  
Smooth Muscle Antibody ◽  
Autoimmune Sclerosing Cholangitis ◽  
Specific Autoantibody ◽  
Circulating Autoantibodies ◽  
International Autoimmune Hepatitis Group

AbstractCirculating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction between type 1 AIH, characterized by positive anti-nuclear and/or anti-smooth muscle antibody, and type 2 AIH, characterized by positive anti-liver kidney microsomal type 1 and/or anti-liver cytosol type 1 antibody. Anti-soluble liver antigen is the only AIH-specific autoantibody, and is found in 20–30% of both type 1 and type 2 AIH. Anti-neutrophil cytoplasmic antibody is frequently positive in type 1 AIH, being associated also with inflammatory bowel disease and with primary/autoimmune sclerosing cholangitis. The reference method for autoantibody testing remains indirect immunofluorescence on triple tissue (rodent liver, kidney and stomach), allowing both the detection of the majority of liver-relevant reactivities, including those autoantibodies whose molecular target antigens are unknown. Of note, the current knowledge of the clinical significance of autoantibodies relies on studies based on this technique. However, immunofluorescence requires trained laboratory personnel, is observer-dependent, and lacks standardization, leading to ongoing attempts at replacing this method with automated assays, the sensitivity, and specificity of which, however, require further studies before they can be used as a reliable alternative to immunofluorescence; currently, they may be used as complementary to immunofluorescence.

Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group criteria in acute-onset autoimmune hepatitis

2011 ◽  
Vol 31 (7) ◽  
pp. 1013-1020 ◽  
Author(s):  
Keiichi Fujiwara ◽  
Shin Yasui ◽  
Akinobu Tawada ◽  
Yoshihiro Fukuda ◽  
Masayuki Nakano ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Diagnostic Value ◽  
Acute Onset ◽  
International Autoimmune Hepatitis Group

scholarly journals Autoimmune Hepatitis: Clinical Manifestations and Diagnostic Criteria

2001 ◽  
Vol 15 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Ian G Mcfarlane
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Scoring System ◽  
Clinical Manifestations ◽  
Chronic Viral Hepatitis ◽  
Published Data ◽  
Group A ◽  
Diagnostic Modalities ◽  
Circulating Autoantibodies ◽  
International Autoimmune Hepatitis Group

In 1998, the International Autoimmune Hepatitis Group - a panel of 40 hepatologists and hepatopathologists from 17 countries who have a particular interest in autoimmune hepatitis (AIH) - undertook a review, in light of subsequent experience, of the descriptive criteria and diagnostic scoring system that it had proposed in 1993 for the diagnosis of AIH. This review (published in 1999) noted that the original descriptive criteria appeared to be quite robust and required only relatively minor modifications to bring them up to date with developments and experience in diagnostic modalities for liver disease in general. Analysis of published data on the application of the original criteria in nearly 1000 patients revealed that the diagnostic scoring system had an overall diagnostic accuracy of 89.8%, with a sensitivity of 98.0%. Specificity for excluding definite AIH in patients with chronic viral hepatitis and circulating autoantibodies or patients with overlapping cholestatic syndromes was 98% to 100%, but specificity for excluding probable AIH in these disorders ranged from only 60% to 80%. Modifications, including adjustments to the weightings against biochemical and histological cholestatic features, have been made to the scoring system to improve its specificity.

scholarly journals Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue

2011 ◽  
Vol 54 (2) ◽  
pp. 374-385 ◽  
Author(s):  
Kirsten Muri Boberg ◽  
Roger W. Chapman ◽  
Gideon M. Hirschfield ◽  
Ansgar W. Lohse ◽  
Michael P. Manns ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Position Statement ◽  
Controversial Issue ◽  
Overlap Syndromes ◽  
International Autoimmune Hepatitis Group

International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis

1999 ◽  
Vol 31 (5) ◽  
pp. 929-938 ◽  
Author(s):  
F. Alvarez ◽  
P.A. Berg ◽  
F.B. Bianchi ◽  
L. Bianchi ◽  
A.K. Burroughs ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Group Report ◽  
Criteria For Diagnosis ◽  
International Autoimmune Hepatitis Group

Is the revised international autoimmune hepatitis group (IAHG) scoring system useful?

2001 ◽  
Vol 34 ◽  
pp. 208
Author(s):  
M. Baragiotta ◽  
W. Craig ◽  
O. James ◽  
H. Mitchison ◽  
D. Burke ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Scoring System ◽  
International Autoimmune Hepatitis Group

scholarly journals Occurrence of autoimmune chronic hepatitis in siblings

2005 ◽  
Vol 62 (7-8) ◽  
pp. 591-594 ◽  
Author(s):  
Darko Nozic ◽  
Jovan Dimitrijevic ◽  
Slavica Knezevic-Usaj
Keyword(s):  
Chronic Hepatitis ◽  
Case Report ◽  
Autoimmune Hepatitis ◽  
Chronic Inflammatory Disease ◽  
Hepatic Tissue ◽  
Unknown Etiology ◽  
Hepatic Parenchyma ◽  
Family Case ◽  
Loss Of Tolerance ◽  
International Autoimmune Hepatitis Group

Background. Autoimmune hepatitis is a chronic inflammatory disease of the liver of unknown etiology, characterized by the loss of tolerance against hepatic tissue, leading to the destruction of hepatic parenchyma. It predominantly affects females, and rarely occurs in the same family. Case report. In this paper we presented brother and sister with autoimmune hepatitis according to the criteria of the International Autoimmune Hepatitis Group. Conclusion. Because of a possible genetic predisposition to autoimmune hepatitis, the occurrence of the disease in a family member suggested the need to examine other family members.

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