scholarly journals Occurrence of autoimmune chronic hepatitis in siblings

2005 ◽  
Vol 62 (7-8) ◽  
pp. 591-594 ◽  
Author(s):  
Darko Nozic ◽  
Jovan Dimitrijevic ◽  
Slavica Knezevic-Usaj
Keyword(s):  
Chronic Hepatitis ◽  
Case Report ◽  
Autoimmune Hepatitis ◽  
Chronic Inflammatory Disease ◽  
Hepatic Tissue ◽  
Unknown Etiology ◽  
Hepatic Parenchyma ◽  
Family Case ◽  
Loss Of Tolerance ◽  
International Autoimmune Hepatitis Group

Background. Autoimmune hepatitis is a chronic inflammatory disease of the liver of unknown etiology, characterized by the loss of tolerance against hepatic tissue, leading to the destruction of hepatic parenchyma. It predominantly affects females, and rarely occurs in the same family. Case report. In this paper we presented brother and sister with autoimmune hepatitis according to the criteria of the International Autoimmune Hepatitis Group. Conclusion. Because of a possible genetic predisposition to autoimmune hepatitis, the occurrence of the disease in a family member suggested the need to examine other family members.

scholarly journals Chronic Hepatitis with Liver Granulomas in a Patient with Granuloma Annulare: A Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Majid Alsahafi ◽  
Mohammed I. AlJasser ◽  
Sunil Kalia ◽  
H. M. Yang ◽  
Alnoor Ramji
Keyword(s):  
Chronic Hepatitis ◽  
Case Report ◽  
Liver Diseases ◽  
Skin Disorder ◽  
Liver Enzymes ◽  
Granuloma Annulare ◽  
Unknown Etiology ◽  
Review Of The Literature ◽  
Unique Case

Granuloma annulare (GA) is a benign granulomatous skin disorder of unknown etiology. GA is rarely associated with liver diseases. We report a unique case of chronic hepatitis with liver granulomas in a patient with GA. Despite an extensive workup, no clear etiology for the hepatitis was found. Based on the possible immune pathophysiology of GA and the presence of liver granulomas, the patient was treated with prednisone and azathioprine which resulted in complete normalization of the liver enzymes and concurrent improvement of GA. The association between liver diseases and GA is reviewed.

scholarly journals Ulcerative colitis in 17 yr old girl masquerading as severe anemia: A case report

2013 ◽  
Vol 1 (04) ◽  
pp. 119-121
Author(s):  
Anil Kumar ◽  
Vivian Praveen ◽  
Gangadhar Belavadi
Keyword(s):  
Ulcerative Colitis ◽  
Case Report ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Severe Anemia ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Case ◽  
Pediatric Age Group ◽  
Upper Gastrointestinal

Ulcerative colitis is a chronic inflammatory disease of unknown etiology. It is localized to the colon and spares the upper gastrointestinal tract. Ulcerative colitis can occur at any age, the peak incidence is among the age group 15-25 years and in 55-65 years. The first pediatric case was reported by Helmholz. The purpose of reporting this case of 17 year old girl with ulcerative colitis who presented with severe anemia is, to not only create awareness of ulcerative colitis among pediatric age group but also to discuss the challenges facing the diagnosis and management of the disease in a developing country like India.

scholarly journals Autoimmiune Hepatitis in Children: Two Case Report

2021 ◽  
Vol 49 (1) ◽  
pp. 45-50
Author(s):  
Md Benzamin ◽  
Zannatul Ferdous Sonia ◽  
Md Rukunuzzaman ◽  
Khan Lamia Nahid ◽  
Bishnu Pada Dey ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Chronic Hepatitis ◽  
Case Report ◽  
Acute Hepatitis ◽  
Autoimmune Hepatitis ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Immune Mediated ◽  
Cirrhosis Of Liver ◽  
Acute And Chronic Hepatitis

Autoimmune hepatitis (AIH) is the disease of immune mediated inflammation of liver. Presentation of AIH in children is variable, ranging from acute hepatitis to cirrhosis of liver and also as only asymptomatic raised ALT. AIH can present at any age and female are more affected. Here we are presenting two cases. Case 1 presented with jaundice and H/O epistaxis, having cutaneous echymosis, hepato-splenomegaly and ascites. Case 2 was a diagnosed case of Systemic Lupus Erythematosus (SLE) presented with only persistent raised of serum ALT. Both were diagnosed as autoimmune hepatitis on the basis of positive auto antibodies, histopathology of liver tissues and exclusion of all other causes of acute and chronic hepatitis. Bangladesh Med J. 2020 Jan; 49 (1): 45-50

scholarly journals Kimura Disease: A case report and review of literature

2018 ◽  
Vol 17 (1) ◽  
pp. 152-154
Author(s):  
Partha Pratim Sinha Roy ◽  
Parthasarathi Ghosh ◽  
Dwaipayan Samaddar ◽  
Gautam Das
Keyword(s):  
Case Report ◽  
Inflammatory Disease ◽  
Medical Science ◽  
Neck Region ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Review Of Literature ◽  
Kimura Disease ◽  
Head And Neck Region ◽  
Blood Eosinophilia

Kimura disease is a rare chronic inflammatory disease with angiolymphatic proliferation of unknown etiology predominantly seen among young Asian males. It classically shows a triad of non-tender subcutaneous masses predominantly in head and neck region with tissue and blood eosinophilia and raised serum IgE level. Here we present a case report of a 24 years male with bilateral pre-auricular and post-auricular swelling for 6 years. The diagnosis of Kimura disease was made on the basis of clinical and histopathological examination.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.152-154

scholarly journals Seronegative Autoimmune Hepatitis A Clinically Challenging Difficult Diagnosis

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Jagannath M. Sherigar ◽  
Arefiev Yavgeniy ◽  
Debra Guss ◽  
Nhu Ngo ◽  
Smruti Mohanty
Keyword(s):  
Liver Disease ◽  
Autoimmune Hepatitis ◽  
Diagnostic Criteria ◽  
Unknown Etiology ◽  
Routine Practice ◽  
Specificity And Sensitivity ◽  
Appropriate Treatment ◽  
Immune Mediated ◽  
Clinical Presentations ◽  
International Autoimmune Hepatitis Group

Autoimmune hepatitis (AIH) is a complex liver disease of unknown cause which results in immune-mediated liver injury with varied clinical presentations. Seronegative AIH follows a similar course to autoantibody-positive disease and diagnosis may be challenging. There are no single serologic tests of sufficient diagnostic specificity, and delay in appropriate treatment may lead to progression of the liver disease and liver failure. The revised conventional diagnostic criteria (RDC) scoring for AIH is complex and not routinely used in the clinical practice. The more recent simplified diagnostic criteria (SDC) scoring proposed by International Autoimmune Hepatitis Group in 2008 has wider application in routine practice facilitating the diagnosis of AIH with a specificity and sensitivity of ~90%. In this report, we describe a case of seronegative autoimmune hepatitis diagnosed using RDC. SDC score calculated in our case was 4 and was not diagnostic for AIH. We subsequently used the complex revised diagnostic criteria for definitive diagnosis. Some of the patients previously diagnosed as cryptogenic active hepatitis of unknown etiology probably had an unrecognized diagnosis of seronegative autoimmune hepatitis. SDC scoring may not be applicable in patients with seronegative autoimmune hepatitis. These patients should be reassessed by using RDC.

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