scholarly journals Determination of Human Papillomavirus (HPV) Load and Type in High-Grade Cervical Lesions Surgically Resected from HIV-Infected Women during Follow-up of HPV Infection

2005 ◽  
Vol 40 (3) ◽  
pp. 451-457 ◽  
Author(s):  
F. B. Lillo ◽  
S. Lodini ◽  
D. Ferrari ◽  
C. Stayton ◽  
G. Taccagni ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
High Grade ◽  
Cervical Lesions

Worldwide incidence of cervical lesions: a systematic review

2014 ◽  
Vol 143 (2) ◽  
pp. 225-241 ◽  
Author(s):  
J. TING ◽  
A. F. ROSITCH ◽  
S. M. TAYLOR ◽  
L. RAHANGDALE ◽  
H. M. SOETERS ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Hpv Infection ◽  
Cervical Cytology ◽  
Low Grade ◽  
High Grade ◽  
Cervical Lesions ◽  
Infection Incidence ◽  
Over Time

SUMMARYWe conducted a systematic review summarizing data on incidence of high- and low-grade lesions in women with normal baseline cervical cytology, stratified by age (<30 and ⩾30 years), and baseline human papillomavirus (HPV) infection. Incidence of high- and low-grade lesions in women aged ⩾30 years with a baseline HPV infection increased over follow-up time (5–127 months), although incidence generally remained <10%. Without baseline HPV infection, incidence of high-grade lesions remained low over follow-up time (<5% over 5–122 months). Incidence of high-grade lesions in women aged ⩾30 years with baseline HPV infection appeared similar to that in women aged <30 years. In some women aged <30 years, high-grade lesions can develop relatively shortly after initial HPV infection. We observed an increase in low-grade lesions over time in women aged ⩾30 years with baseline HPV infection, potentially indicative of an HPV infection that is potentially progressing to higher grade lesions.

scholarly journals Human papillomavirus and abnormal cervical lesions among HIV-infected women in HIV-discordant couples from Kenya

2020 ◽  
Vol 96 (6) ◽  
pp. 457-463 ◽  
Author(s):  
Brandon L Guthrie ◽  
Anne F Rositch ◽  
Joy Alison Cooper ◽  
Carey Farquhar ◽  
Rose Bosire ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Cervical Neoplasia ◽  
Cervical Cytology ◽  
High Grade ◽  
Cervical Lesions ◽  
Hpv Prevalence ◽  
High Grade Lesion ◽  
Hpv Types ◽  
Hpv Screening

ObjectiveHIV infection increases the risk of high-grade cervical neoplasia and invasive cervical carcinoma. The study addresses the limited data describing human papillomavirus (HPV) infection and cervical neoplasia among HIV-infected women in HIV-discordant relationships in sub-Saharan Africa, which is needed to inform screening strategies.MethodsA cross-sectional study of HIV-infected women with HIV-uninfected partners was conducted to determine the distribution of type-specific HPV infection and cervical cytology. This study was nested in a prospective cohort recruited between September 2007 and December 2009 in Nairobi, Kenya. Cervical cells for HPV DNA testing and conventional cervical cytology were collected. HPV types were detected and genotyped by Roche Linear Array PCR assay.ResultsAmong 283 women, the overall HPV prevalence was 62%, and 132 (47%) had ≥1 high-risk (HR)-HPV genotype. Of 268 women with cervical cytology results, 18 (7%) had high-grade cervical lesions or more severe by cytology, of whom 16 (89%) were HR-HPV-positive compared with 82 (41%) of 199 women with normal cytology (p<0.001). The most common HR-HPV types in women with a high-grade lesion or more severe by cytology were HPV-52 (44%), HPV-31 (22%), HPV-35 (22%), HPV-51 (22%) and HPV-58 (22%). HR-HPV genotypes HPV-16 or HPV-18 were found in 17% of women with high-grade lesions or more severe. HR-HPV screening applied in this population would detect 89% of those with a high-grade lesion or more severe, while 44% of women with normal or low-grade cytology would screen positive.ConclusionHR-HPV prevalence was high in this population of HIV-infected women with an uninfected partner. Choice of screening for all HR genotypes versus a subset of HR genotypes in these HIV-infected women will strongly affect the performance of an HPV screening strategy relative to cytological screening. Regional and subpopulation differences in HR-HPV genotype distributions could affect screening test performance.

scholarly journals Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Hui Zhong ◽  
Yao Tong ◽  
Haifeng Lin ◽  
Xiaodan Mao ◽  
Binhua Dong ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Genital Tract ◽  
Hpv Infection ◽  
High Grade ◽  
Infection Rates ◽  
Squamous Intraepithelial Lesions ◽  
Cervical Lesions ◽  
Lower Genital Tract ◽  
Intraepithelial Lesions

Purpose. This study investigated the infection status and relationship between other common lower genital tract infectious pathogens and high-risk human papillomavirus (HR-HPV) in the high-grade cervical lesions. Methods. Overall, 882 patients were enrolled in this retrospective study, of which 339 patients (≥HSIL group) were confirmed with high-grade squamous intraepithelial lesions (HSIL) or cervical squamous cell carcinoma (SCC), while 543 patients (≤LSIL group) were diagnosed with low-grade squamous intraepithelial lesions (LSIL) or normal cervical pathology diagnosis. Cervical swab specimens were tested for HPV, pathogenic bacteria (PB), U. urealyticum (UU), M. hominis (MH), and C. trachomatis (CT) in both groups. Results. The infection rates of HR-HPV, PB, UU (at high density), and CT were higher in the ≥HSIL group than in the ≤LSIL group (P<0.001); however, higher infection rates with MH were not observed (P>0.05). PB, UU, and CT were associated with HR-HPV infection (P<0.001). The PB and UU infection rates in the ≥HSIL group were significantly different from those in the ≤LSIL group, regardless of whether there was an HR-HPV infection at the same time (P<0.05). However, this was not the case for the CT (P>0.05). Furthermore, 259 pathogenic bacterial strains were detected in 882 cases. The difference in the distribution of pathogenic bacterial flora in the different grades of cervical lesions had no statistical significance, which was prioritized over Escherichia coli (P>0.05). Conclusion. PB, UU, and CT infection is associated with susceptibility to HR-HPV, HR-HPV coinfection with these pathogens might increase the risk of high-grade cervical lesions, and PB and UU might be independent risk factors for cervical lesions.

scholarly journals Correlation of hTERT Expression with Cervical Cytological Abnormalities and Human Papillomavirus Infection

PRILOZI ◽  
2017 ◽  
Vol 38 (3) ◽  
pp. 143-151
Author(s):  
Vjosa A. Zejnullahu ◽  
Valon A. Zejnullahu ◽  
Slavica Josifovska ◽  
Nikola Vukovik ◽  
Kiril Pakovski ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Reverse Transcriptase ◽  
Hpv Infection ◽  
Cell Phenotype ◽  
Transcriptional Level ◽  
Low Grade ◽  
High Grade ◽  
Htert Expression ◽  
Cervical Lesions

AbstractTelomerase Reverse Transcriptase (TERT) is the main catalytic sub-unit of telomerase, a reverse transcriptase enzyme. Telomerase expression is regulated at many levels, with numerous studies suggesting that up-regulation of human TERT gene (hTERT) at transcriptional level results in immortal cell phenotype associated with cancer. The aim of this study is to determine the correlation between hTERT expression and different cervical precursor lesions, as well as with cervical cancer in patients with confirmed Human papillomavirus (HPV) infection.The study included molecular analyzes on cervical samples from 214 women and matched Papanicolaou (Pap) test results. HPV detection and genotyping was performed by polymerase chain reaction (PCR) and genotyping. Quantitative real-time PCR (qRT-PCR) was performed using TaqMan probes and were calculated relative to the reference gene.Results showed significantly increased hTERT mRNA expression levels in high-grade and low-grade lesions compared to normal control samples (p<0.01) associated with 6.31 fold higher risk for developing ASC-US and 9.20 for LSIL. Strong correlation between HPV infection and hTERT expression in the high-grade lesions and cervical cancer was also observed. hTERT relative expression values showed 98% specificity and 100 % sensitivity as indicator of cervical lesions particularly for the ACS-H, HSIL and cervical cancer. In conclusion, hTERT expression correlate with the cytological grade of the cervical lesions and HPV infection and has a potential to be used as a diagnostic and prognostic marker.

scholarly journals Human papillomavirus infection and follow-up on positive results in 7222 female samples obtained from 2016 to 2019 in Hefei, China

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10179
Author(s):  
Liduo Peng ◽  
Liping Yin ◽  
Yaqian Dai ◽  
Yuanjing Peng ◽  
Yuanhong Xu ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Age Groups ◽  
Hpv Infection ◽  
Single Infection ◽  
Cervical Lesions ◽  
Positive Rate ◽  
Cervical Cells ◽  
Risk Infection

Background Human papillomavirus (HPV) infection rates in women vary regionally. This study analyzed HPV infection in women of different age groups in Hefei, China, performed follow-up on positive cases, and discussed infection prognoses. Methods Samples (7,222) of exfoliated cervical cells were collected in Hefei and tested with an HPV assay kit against 27 HPV genotypes. Statistical software was used to analyze the data. Results The total positive rate of infection was 17.13% (1,068 women), and the 51–60-year age group had the highest HPV infection rate (19.82%). There were statistically significant differences between rates in the 21–30 and 31–40 (P = 0.002), 21–30 and 41–50 (P = 0.0003), 21–30 and 51–60 (P = 0.00003), and 51–60 and >60 age groups (P = 0.046). High-risk infection (15.67%) and single infection (13.01%) were the main types of HPV infection. The dominant genotypes of high-risk infection were HPV 52 (2.42%), HPV 16 (2.01%), HPV 53 (1.43%), HPV 58 (1.32%) and HPV 66 (1.01%). We conducted follow-up on cases in 69 of 94 women who had a history of 1–4 years of positive infection, and in 18 (seven treated, 11 untreated) patients, infection status turned negative (26.09%). Seventeen of the fifty-one women whose infections did not turn negative received treatment. Persistent infection was predominantly observed in high-risk genotypes (56 of 69). Conclusions The results recommend that women in Hefei improve health awareness and receive a 9-valent vaccine. Additionally, women with persistent infections should consult a gynecologist to prevent cervical lesions.

Genotype-Specific HPV Infection and Cumulative Risk of High Grade Cervical Lesions with Long-Term Follow-Up

2018 ◽  
Vol 7 (5) ◽  
pp. S63
Author(s):  
Irene Thung ◽  
Paul Christensen ◽  
Haijun Steve Zhou ◽  
Mary Schwartz ◽  
Dina Mody ◽  
...  
Keyword(s):  
Cumulative Risk ◽  
Hpv Infection ◽  
High Grade ◽  
Cervical Lesions ◽  
Long Term Follow Up

Aptima Human Papillomavirus E6/E7 mRNA Test Results Strongly Associated With Risk for High-Grade Cervical Lesions in Follow-Up Biopsies

2018 ◽  
Vol 22 (3) ◽  
pp. 195-200 ◽  
Author(s):  
Yimin Ge ◽  
Paul Christensen ◽  
Eric Luna ◽  
Donna Armylagos ◽  
Jiaqiong Xu ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Grade ◽  
Test Results ◽  
Cervical Lesions

Negative Pap tests in women with high-grade cervical lesions on follow-up biopsies: Contributing factors and role of human papillomavirus genotyping

2017 ◽  
Vol 46 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Steven Goodman ◽  
Roxanne R. Mody ◽  
Donna Coffey ◽  
Blythe K. Gorman ◽  
Eric Luna ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Grade ◽  
Contributing Factors ◽  
Cervical Lesions ◽  
Pap Tests
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