scholarly journals D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients

2011 ◽  
Vol 24 (4) ◽  
pp. 502-511 ◽  
Author(s):  
Einar Gudlaugsson ◽  
Ivar Skaland ◽  
Erling Undersrud ◽  
Emiel AM Janssen ◽  
Håvard Søiland ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Lymph Vessel ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion ◽  
Node Negative Breast Cancer

scholarly journals Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients

2016 ◽  
Vol 51 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Nina Fokter Dovnik ◽  
Iztok Takac
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Multivariate Model ◽  
Her2 Status ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Size Grade ◽  
Pai 1

Abstract Background The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from HER2 status. The aim of our study was to compare the prognostic value of uPA/PAI-1 level, HER2 status, and traditional prognostic factors for survival in node-negative breast cancer patients. Patients and methods A retrospective analysis of 858 node-negative breast cancer patients treated in Maribor University Clinical Center, Slovenia, in the years 2000–2009 was performed. Data were obtained from patient medical records. The median follow-up time was 100 months. Univariate and multivariate analyses of disease-free (DFS) and overall survival (OS) were performed using the Cox regression and the Cox proportional hazards model. Results In univariate analysis, age, tumor size, grade, lymphovascular invasion, HER2 status and UPA/PAI-1 level were associated with DFS, and age, tumor size, grade, and uPA/PAI-1 level were associated with OS. In the multivariate model, the most important determinants of DFS were age, estrogen receptor status and uPA/PAI-1 level, and the most important factors for OS were patient age and tumor grade. The HR for death from any cause in the multivariate model was 1.98 (95% CI 0.83–4.76) for patients with high uPA and/or PAI-1 compared to patients with both values low. Conclusions uPA/PAI-1 level clearly carries an independent prognostic value regardless of HER2 status in node-negative breast cancer and could be used in addition to HER2 and other markers to guide clinical decisions in this setting.

scholarly journals Significance of lymph vessel invasion identified by the endothelial lymphatic marker D2-40 in node negative breast cancer

2007 ◽  
Vol 20 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Angel Arnaout-Alkarain ◽  
Harriette J Kahn ◽  
Steven A Narod ◽  
Ping A Sun ◽  
Alexander N Marks
Keyword(s):  
Breast Cancer ◽  
Lymph Vessel ◽  
Node Negative ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion ◽  
Node Negative Breast Cancer

The prognostic value of proliferation in lymph-node-negative breast cancer patients is age dependent

2007 ◽  
Vol 43 (3) ◽  
pp. 527-535 ◽  
Author(s):  
Jan P.A. Baak ◽  
Paul J. van Diest ◽  
Feja J. Voorhorst ◽  
Elsken van der Wall ◽  
Louk V.A.M. Beex ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Age Dependent

Prognostic value of Tumoral Sialyltransferase Expression and Circulating E-Selectin Concentrations in Node-Negative Breast Cancer Patients

2003 ◽  
Vol 18 (2) ◽  
pp. 116-122 ◽  
Author(s):  
M. Hebbar ◽  
M.-A. Krzewinski-Recchi ◽  
L. Hornez ◽  
A. Verdière ◽  
A. Harduin-Lepers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Breast Cancer Patients ◽  
Free Survival ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Metastatic Process ◽  
St3gal Iii ◽  
St6gal I

Aims and Background A crucial step in the metastatic process is the interaction between the endothelial molecule E-selectin and its tumoral ligands sialyl-Lewisx and sialyl-Lewisa. Sialyltranferases are involved in the biosynthesis of these ligands. The aim of this study was to assess the prognostic value of tumoral sialyltransferase expression and of circulating soluble E-selectin (sE-selectin) in node-negative breast cancer patients. Methods Using a multiplex RT-PCR method, we measured the expression of five sialyltransferases (ST3Gal III, ST6Gal I, ST3Gal IV, ST3Gal I and ST3Gal II) in tumors of 135 surgically treated node-negative breast cancer patients. Circulating sE-selectin concentrations were measured by an ELISA method prior to surgery. We also analyzed tumor size, histoprognostic grading and steroid hormone receptor status. Results The median follow-up was 7.5 years. Expression of estrogen receptors was associated with a good prognosis for relapse-free survival in univariate analysis. A high ST3Gal III/ST6Gal I ratio and a high sE-selectin concentration were associated with a bad prognosis for relapse-free survival and overall survival in univariate and multivariate analysis. Conclusion In the present study, tumoral sialyltransferase expression and circulating sE-selectin concentrations had prognostic value in patients with node-negative breast cancer. This result provides further evidence for the important role of these agents in the metastatic process.

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