scholarly journals International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease

2010 ◽  
Vol 24 (1) ◽  
pp. 26-38 ◽  
Author(s):  
Cristina Magi-Galluzzi ◽  
◽  
Andrew J Evans ◽  
Brett Delahunt ◽  
Jonathan I Epstein ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
International Society ◽  
Working Group ◽  
Lymphovascular Invasion ◽  
Advanced Disease ◽  
Locally Advanced ◽  
Consensus Conference ◽  
Locally Advanced Disease ◽  
Group 3 ◽  
Extraprostatic Extension

scholarly journals Laparoscopic radical prostatectomy for high risk localized and locally advanced disease

2012 ◽  
Vol 38 (3) ◽  
pp. 430-431 ◽  
Author(s):  
Marcos Tobias-Machado ◽  
Eduardo S. Starling ◽  
Alexandre Stievano Carlos ◽  
Antonio C. L. Pompeo ◽  
Pedro Romanelli ◽  
...  
Keyword(s):  
High Risk ◽  
Radical Prostatectomy ◽  
Advanced Disease ◽  
Locally Advanced ◽  
Laparoscopic Radical Prostatectomy ◽  
Locally Advanced Disease

scholarly journals Obesity is Associated with Upgrading in Prostate Cancers

Folia Medica ◽  
2018 ◽  
Vol 60 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Mustafa Sungur ◽  
Selahattin Çalışkan
Keyword(s):  
Radical Prostatectomy ◽  
Advanced Disease ◽  
Locally Advanced ◽  
High Grade ◽  
Locally Advanced Disease ◽  
Oncological Results ◽  
The Difference ◽  
Prostate Cancers ◽  
The Impact ◽  
The Relationship

Abstract Background: Prostate cancer (PCa) is the second most common cancer and sixth most common cause of cancer associated death among men in the world. Multiple studies demonstrated the relationship between obesity and PCa in the recent years. Aim: The present study aimed to investigate the impact of obesity on postoperative oncological results after radical prostatectomy. Materials and methods: A total of 110 patients who were treated radical prostatectomy between January 2011 and April 2016 were analyzed retrospectively. The patients who had information about age, height, weight, biopsy results, PSA level and pathological results were recorded. The patients were classified to three groups according to the BMI; normal (BMI<25 kg/m2), overweight (BMI>25 and <30 kg/m2) and obese (BMI>30 kg/m2). Results: The present study included 101 patients. Of these patients; 26, 57 and 18 patients were in groups respectively. The age at the presentation and PSA level was lower and higher than the other patients. The proportion of locally advanced disease and high grade PCa were the highest in obese patients at prostatectomy specimen examination. The upgrading is significantly associated with obesity. Conclusion: This study demonstrated that obese men are younger and had higher PSA concentration at the diagnosis of PCa. High grade PCa, locally advanced disease and upgrading was seen much more in patients with BMI>30 kg/m2 at final pathology. The difference reached significance for upgrading between groups.

Combination of AST to ALT and neutrophils to lymphocytes ratios as predictors of locally advanced disease in patients with bladder cancer subjected to radical cystectomy: Results from a single-institutional series

2021 ◽  
pp. 039156032110351
Author(s):  
Alessandro Uleri ◽  
Rodolfo Hurle ◽  
Roberto Contieri ◽  
Pietro Diana ◽  
Nicolòmaria Buffi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Advanced Disease ◽  
Independent Predictor ◽  
Small Sample Size ◽  
Statistical Significance ◽  
Locally Advanced ◽  
Small Sample ◽  
Locally Advanced Disease ◽  
Increased Risk

Background: Bladder cancer (BC) staging is challenging. There is an important need for available and affordable predictors to assess, in combination with imaging, the presence of locally-advanced disease. Objective: To determine the role of the De Ritis ratio (DRR) and neutrophils to lymphocytes ratio (NLR) in the prediction of locally-advanced disease defined as the presence of extravescical extension (pT ⩾ 3) and/or lymph node metastases (LNM) in patients with BC treated with radical cystectomy (RC). Methods: We retrospectively analyzed clinical and pathological data of 139 consecutive patients who underwent RC at our institution. Logistic regression models (LRMs) were fitted to test the above-mentioned outcomes. Results: A total of 139 consecutive patients underwent RC at our institution. Eighty-six (61.9%) patients had a locally-advanced disease. NLR (2.53 and 3.07; p = 0.005) and DRR (1 and 1.17; p = 0.01) were significantly higher in patients with locally-advanced disease as compared to organ-confined disease. In multivariable LRMs, an increasing DRR was an independent predictor of locally-advanced disease (OR = 3.91; 95% CI: 1.282–11.916; p = 0.017). Similarly, an increasing NLR was independently related to presence of locally-advanced disease (OR = 1.28; 95% CI: 1.027–1.591; p = 0.028). In univariate LRMs, patients with DRR > 1.21 had a higher risk of locally advanced disease (OR = 2.83; 95% CI: 1.312–6.128; p = 0.008). Similarly, in patients with NLR > 3.47 there was an increased risk of locally advanced disease (OR = 3.02; 95% CI: 1.374–6.651; p = 0.006). In multivariable LRMs, a DRR > 1.21 was an independent predictor of locally advanced disease (OR = 2.66; 95% CI: 1.12–6.35; p = 0.027). Similarly, an NLR > 3.47 was independently related to presence of locally advanced disease (OR = 2.24; 95% CI: 0.95–5.25; p = 0.065). No other covariates such as gender, BMI, neoadjuvant chemotherapy or diabetes reached statistical significance. The AUC of the multivariate LRM to assess the risk of locally advanced disease was 0.707 (95% CI: 0.623–0.795). Limitations include the retrospective nature of the study and the relatively small sample size.

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