scholarly journals Poor prognostic significance of unamplified chromosome 17 polysomy in invasive breast carcinoma

2009 ◽  
Vol 22 (8) ◽  
pp. 1044-1048 ◽  
Author(s):  
Uma Krishnamurti ◽  
Jennifer L Hammers ◽  
Folefac D Atem ◽  
Patrick D Storto ◽  
Jan F Silverman
Keyword(s):  
Breast Carcinoma ◽  
Prognostic Significance ◽  
Invasive Breast Carcinoma ◽  
Chromosome 17

Cyclin D1 in invasive breast carcinoma: favourable prognostic significance in unselected patients and within subgroups with an aggressive phenotype

2012 ◽  
Vol 62 (3) ◽  
pp. 472-480 ◽  
Author(s):  
Eleni Mylona ◽  
Konstantinos Tzelepis ◽  
Irene Theohari ◽  
Ioanna Giannopoulou ◽  
Christos Papadimitriou ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Cyclin D1 ◽  
Prognostic Significance ◽  
Invasive Breast Carcinoma ◽  
Aggressive Phenotype

Is tumor cellularity in primary invasive breast carcinoma of prognostic significance?

2017 ◽  
Vol 470 (6) ◽  
pp. 611-617 ◽  
Author(s):  
Emily S. Reisenbichler ◽  
William Dupont ◽  
W. Dale Plummer ◽  
Omar Hameed
Keyword(s):  
Breast Carcinoma ◽  
Prognostic Significance ◽  
Invasive Breast Carcinoma

Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma

2001 ◽  
Vol 19 (16) ◽  
pp. 3660-3668 ◽  
Author(s):  
Stephen K. Chia ◽  
Charles C. Wykoff ◽  
Peter H. Watson ◽  
Cheng Han ◽  
Russell D. Leek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Breast Carcinoma ◽  
Carbonic Anhydrase ◽  
Invasive Breast Cancer ◽  
Estrogen Receptor Status ◽  
Prognostic Significance ◽  
Invasive Breast Carcinoma ◽  
Carbonic Anhydrase Ix ◽  
Ca Ix

PURPOSE: To assess the frequency of expression and the prognostic significance of a hypoxia-regulated marker, carbonic anhydrase IX (CA IX), in a cohort of patients with invasive breast cancer. PATIENTS AND METHODS: CA IX expression was evaluated by immunohistochemistry with a murine monoclonal antibody, M75, in a series of 103 women treated surgically for invasive breast cancer. The majority of patients were treated with adjuvant hormonal or chemotherapy. The frequency of CA IX expression, its association with recognized prognostic factors, and the relationship with outcome was evaluated by univariate and multivariate statistical analyses. RESULTS: CA IX expression was present in 49 (48%) of 103 cases. The level of CA IX expression was found to be significantly associated with tumor necrosis (P < .001), higher grade (P = .02), and negative estrogen receptor status (P < .001). Furthermore, CA IX expression was associated with a higher relapse rate (P = .004) and a worse overall survival (P = .001). By multivariate analysis, CA IX was also shown to be an independent predictive factor for overall survival (hazard ratio, 2.61; 95% confidence interval, 1.01 to 6.75, P = .05). CONCLUSION: CA IX expression was associated with worse relapse-free survival and overall survival in an unselected cohort of patients with invasive breast carcinoma. The potential role of CA IX as a marker of hypoxia within breast carcinomas was also indicated by a significant association with necrosis. Further work assessing its prognostic significance in breast cancer is warranted, particularly interactions with radiotherapy and chemotherapy resistance.

Chromosome 17 Aneusomy is Associated with Poor Prognostic Factors in Invasive Breast Carcinoma

2003 ◽  
Vol 77 (2) ◽  
pp. 109-114 ◽  
Author(s):  
A.D. Watters ◽  
J.J. Going ◽  
T.G. Cooke ◽  
J.M.S. Bartlett
Keyword(s):  
Prognostic Factors ◽  
Breast Carcinoma ◽  
Invasive Breast Carcinoma ◽  
Chromosome 17

Clinical role of HER2 gene amplification and chromosome 17: a study on 154 IHC-equivocal cases of invasive breast carcinoma patients

Tumor Biology ◽  
2016 ◽  
Vol 37 (7) ◽  
pp. 8665-8672 ◽  
Author(s):  
Muhammad Afzal ◽  
Mohammed Amir ◽  
Muhammad Jawad Hassan ◽  
Muhammad Sikander Hussain ◽  
Muhammad Naveed Aziz ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Gene Amplification ◽  
Invasive Breast Carcinoma ◽  
Chromosome 17 ◽  
Her2 Gene ◽  
Clinical Role ◽  
Her2 Gene Amplification
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