scholarly journals Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23

2014 ◽  
Vol 8 (3) ◽  
pp. 582-595 ◽  
Author(s):  
D S Donaldson ◽  
B M Bradford ◽  
D Artis ◽  
N A Mabbott
Keyword(s):  
Large Intestine ◽  
Lymphoid Tissue ◽  
Tissue Development ◽  
Reciprocal Regulation

scholarly journals Gut-associated Lymphoid Tissue in the Large Intestine of Calves. II. Electron Microscopy

1988 ◽  
Vol 25 (6) ◽  
pp. 509-515 ◽  
Author(s):  
E. M. Liebler ◽  
J. F. Pohlenz ◽  
N. F. Cheville
Keyword(s):  
Electron Microscopy ◽  
Large Intestine ◽  
Lymphoid Tissue ◽  
Cell Types ◽  
Goblet Cells ◽  
M Cells ◽  
Muscularis Mucosae ◽  
Transmission Electron ◽  
Luminal Side ◽  
Follicle Associated Epithelium

Scanning electron microscopy of lymphoid tissue in the large intestine of three germfree calves (age 3, 6, and 7 days) revealed two different units: propria nodules and lymphoglandular complexes (LGC). Propria nodules had lymphoid tissue predominantly in lamina propria and were covered by distinct follicle-associated epithelium which lacked goblet cells; nodules were surrounded by wide crypts, which were also lined by follicle-associated epithelium towards the luminal side. Lymphoglandular complexes had lymphoid follicles in the tunica submucosa; epithelial diverticulae extended through the muscularis mucosae branching into the lymphoid nodule. In centers of lymphoglandular complexes, protrusions of lymphoid tissue were covered with distinct follicle-associated epithelium. By transmission electron microscopy cells compatible with M cells in the small intestine of calves and cells with characteristics of both enteroabsorptive and M cells were found. Follicle-associated epithelium of propria nodules and lymphoglandular complexes differed only in the relative frequency of cell types.

Facilitation of Host Lymphoid Tissue Development in Neonatally Thymectomized Mice by Injection of Allogeneic Dispersed Thymus Cells

Nature ◽  
1964 ◽  
Vol 204 (4961) ◽  
pp. 850-853 ◽  
Author(s):  
EDMOND J. YUNIS ◽  
CARLOS MARTINEZ ◽  
JUNE SMITH ◽  
ROBERT A. GOOD
Keyword(s):  
Lymphoid Tissue ◽  
Tissue Development ◽  
Thymus Cells ◽  
Thymectomized Mice

scholarly journals Nkx2-3—A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies

2018 ◽  
Vol 13 ◽  
pp. 117727191875748 ◽  
Author(s):  
Dóra Vojkovics ◽  
Zoltán Kellermayer ◽  
Béla Kajtár ◽  
Giovanna Roncador ◽  
Áron Vincze ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Transcriptional Regulators ◽  
Slippery Slope ◽  
Regional Differentiation ◽  
Lymphoid Tissues ◽  
Tissue Development ◽  
Tissue Specific ◽  
Gut Inflammation ◽  
Hematopoietic Malignancies

The development of peripheral lymphoid tissues from the mesoderm is the result of a complex convergence combining lymphohematopoietic differentiation with the local specification of nonhematopoietic mesenchymal components. Although the various transcriptional regulators with fate-determining effects in diversifying the mobile leukocyte subsets have been thoroughly studied and identified, the tissue-specific determinants promoting the regional differentiation of resident mesenchyme are less understood. Of these factors, various members of the NK-class Nkx paralogues have emerged as key regulators for the organogenesis of spleen and mucosal lymphoid tissues, and recent data have also indicated their involvement in various pathological events, including gut inflammation and hematopoietic malignancies. Here, we summarize available data on the roles of Nkx2-3 in lymphoid tissue development and discuss its possible value as a developmental marker and disease-associated pathogenic trait.

CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair

FEBS Letters ◽  
2007 ◽  
Vol 581 (18) ◽  
pp. 3550-3556 ◽  
Author(s):  
Siân Lax ◽  
Tie Zheng Hou ◽  
Eric Jenkinson ◽  
Mike Salmon ◽  
John R. MacFadyen ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Lymphoid Tissue ◽  
Tissue Development

scholarly journals Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development

2010 ◽  
Vol 16 (10) ◽  
pp. 1751-1762 ◽  
Author(s):  
Caihong Wang ◽  
Elyse K. Hanly ◽  
Leroy W. Wheeler ◽  
Manreet Kaur ◽  
Keely G. McDonald ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Lymphocyte Subsets ◽  
Tissue Development ◽  
Intestinal Lymphocyte

Morphologic Observation of Mucosa-Associated Lymphoid Tissue in the Large Intestine of Bactrian Camels (Camelus bactrianus)

2014 ◽  
Vol 297 (7) ◽  
pp. 1292-1301 ◽  
Author(s):  
YINGPAI ZhaXi ◽  
Wenhui Wang ◽  
Wangdong Zhang ◽  
Qiang Gao ◽  
Minggang Guo ◽  
...  
Keyword(s):  
Large Intestine ◽  
Lymphoid Tissue ◽  
Camelus Bactrianus ◽  
Bactrian Camels

scholarly journals Gut-associated Lymphoid Tissue in the Large Intestine of Calves. I. Distribution and Histology

1988 ◽  
Vol 25 (6) ◽  
pp. 503-508 ◽  
Author(s):  
E. M. Liebler ◽  
J. F. Pohlenz ◽  
G. N. Woode
Keyword(s):  
Large Intestine ◽  
Lymphoid Tissue ◽  
Proximal Colon ◽  
Intestinal Wall ◽  
Ascending Colon ◽  
Lymphoid Follicles ◽  
Different Types ◽  
Group A ◽  
Group B ◽  
Intraepithelial Cells

Gut-associated lymphoid tissue (GALT) in the large intestine was characterized in 12 calves (10 to 84 days old) obtained at necropsy (7, group A) or healthy animals (5, group B). Patches of mucosal lymphoid follicles were in all calves at ileocecal entrances (ICE), 23–42 cm distal to the ICE in the proximal loop of the ascending colon (proximal colon [PC] patch), and in the terminal rectum. PC patches varied from 8 to 30 cm in length. Solitary lymphoid follicles were found in the cecum of three calves, between the ileocecal entrances and the PC patch in four calves, adjacent to the PC patch in all calves, and in the ampulla recti. GALT occupied 7.8% of the large intestinal wall in animals of group A: 0.6% at the ileocecal entrance, 4.8% in the proximal colon, and 2.4% in the rectum. There were two different types of mucosal lymphoid follicles in group B: propria nodules with lymphoid follicles predominantly in the lamina propria, and lymphoglandular complexes with lymphoid follicles in the submucosa. In three 3-, 6-, and 7-day-old, germfree calves, distinct follicle-associated epithelium covered propria nodules and covering folds in depths of the lymphoglandular complexes; it was characterized by numerous intraepithelial cells and lack of goblet cells.

Investigation of Bovine Gut Associated Lymphoid Tissue (GALT) Using Monoclonal Antibodies against Bovine Lymphocytes

1989 ◽  
Vol 26 (5) ◽  
pp. 396-408 ◽  
Author(s):  
K. R. Parsons ◽  
C. J. Howard ◽  
B. V. Jones ◽  
P. Sopp
Keyword(s):  
Monoclonal Antibodies ◽  
Large Intestine ◽  
Lymphoid Tissue ◽  
Peyer's Patches ◽  
T Cell Subsets ◽  
Lymphoid Tissues ◽  
Peyer’S Patches ◽  
T Lymphocyte Subsets ◽  
Bovine Lymphocytes ◽  
Small And Large Intestine

Gut associated lymphoid tissue of the small and large intestine of calves and cows has been compared morphologically and quantitatively using monoclonal antibodies to bovine lymphocytes. B cells were significantly decreased in the ileum of the cow compared to the calf. Significantly increased numbers of T cells were present in cell suspensions of all lymphoid areas of the cow compared to the calf. T lymphocyte subsets were quantified into cryostat sections of lymphoid tissues expressing BoT4, and BoT8 antigens demonstrated increased numbers in follicular and dome areas of the discrete Peyer's patches of the small and large intestine of the cow. BoT4+, BoT8+, and the non-BoT4+/BoT8+ T cell subsets were increased in the mucosa of the jejunum, ileum, and cecum, while only BoT8+ lymphocytes were increased in the colonic mucosa of the cow as compared to the calf. Similarities in structure and lymphocyte composition of the discrete Peyer's patches of the small intestine, cecum and colon and isolated single follicles in the large intestine suggest similar functional properties.

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