scholarly journals Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity

1996 ◽  
Vol 50 (5) ◽  
pp. 1634-1640 ◽  
Author(s):  
Oleh G. Pankewycz ◽  
Li Miao ◽  
Ross Isaacs ◽  
Jing Guan ◽  
Tim Pruett ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Renal Tubular

The Effects of Cyclosporine on Protein Expression of P53 and Transforming Growth Factor-Beta in Human Renal Tubular Cells

2000 ◽  
Vol 6 (S2) ◽  
pp. 604-605
Author(s):  
H. Song ◽  
C. Wei
Keyword(s):  
Growth Factor ◽  
Cyclosporine A ◽  
Transforming Growth Factor Beta ◽  
Renal Cell ◽  
Transforming Growth Factor ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Cellular Apoptosis ◽  
Growth Factor Beta ◽  
Renal Tubular

Cyclosporine-A (CsA) is the widely used immunosuppressant drug in renal transplantation. However, the effects of cyclosporine-A are limited by a significant nephrotoxicity. The mechanisms of CsA-induced allograft nephropathy are remaining controversial. Recent study indicated that cellular apoptosis may contribute to the cyclosporine A-mediated cytotoxic action. To date, regarding the effects of cyclosporine A on renal cell apoptosis-related gene expression remain poorly defined. p53 is an important gene in control of renal cell growth and death. Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that has anti-proliferative as well as fibrogenic properties.We hypothesized that cyclosporine-A may increase p53 and TGF-β expression in renal tubular cells. These actions of cyclosporine-A may contribute to the cellular apoptosis, fibrosis and CsA-induced nephrotoxicity. Therefore, current study was designed to determine the effects of cyclosporine-A on the p53 and TGF-βl protein expression by immunohistochemical staining (IHCS) in cultured human tubular cells.

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