scholarly journals Highly efficient adenovirus-mediated gene transfer into renal cells in culture

1995 ◽  
Vol 47 (1) ◽  
pp. 322-326 ◽  
Author(s):  
Hangil Chang ◽  
Tetsuo Katoh ◽  
Masakuni Noda ◽  
Yumi Kanegae ◽  
Izumu Saito ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Renal Cells ◽  
Cells In Culture ◽  
Highly Efficient

scholarly journals Achieving highly efficient gene transfer to the bladder by increasing the molecular weight of polymer-based nanoparticles

2021 ◽  
Vol 332 ◽  
pp. 210-224
Author(s):  
Gang Li ◽  
Shanshan He ◽  
Andreas G. Schätzlein ◽  
Robert M. Weiss ◽  
Darryl T. Martin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Transfer ◽  
Highly Efficient ◽  
Efficient Gene

Highly efficient cell-mediated gene transfer using non-viral vectors and FuGene™6: in vitro and in vivo studies

2000 ◽  
Vol 57 (8) ◽  
pp. 1326-1333 ◽  
Author(s):  
I. Hellgren* ◽  
V. Drvota ◽  
R. Pieper ◽  
S. Enoksson ◽  
P. Blomberg ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Viral Vectors ◽  
In Vivo Studies ◽  
Highly Efficient

scholarly journals Highly-efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin

1998 ◽  
Vol 102 (2) ◽  
pp. 566-574 ◽  
Author(s):  
Boris Fehse ◽  
Ulrika M Schade ◽  
Zhixiong LI ◽  
Almut Uhde ◽  
Stefan Koch ◽  
...  
Keyword(s):  
Gene Transfer ◽  
T Lymphocytes ◽  
Retroviral Vectors ◽  
Highly Efficient ◽  
Human T Lymphocytes ◽  
Efficient Gene

scholarly journals Local Gene Delivery System by Bubble Liposomes and Ultrasound Exposure into Joint Synovium

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Yoichi Negishi ◽  
Yuka Tsunoda ◽  
Yoko Endo-Takahashi ◽  
Yusuke Oda ◽  
Ryo Suzuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Imaging System ◽  
Effective Means ◽  
Gene Delivery System ◽  
Highly Efficient ◽  
Efficient Gene

Recently, we have developed novel polyethylene glycol modified liposomes (bubble liposomes; BL) entrapping an ultrasound (US) imaging gas, which can work as a gene delivery tool with US exposure. In this study, we investigated the usefulness of US-mediated gene transfer systems with BL into synoviocytes in vitro and joint synovium in vivo. Highly efficient gene transfer could be achieved in the cultured primary synoviocytes transfected with the combination of BL and US exposure, compared to treatment with plasmid DNA (pDNA) alone, pDNA plus BL, or pDNA plus US. When BL was injected into the knee joints of mice, and US exposure was applied transcutaneously to the injection site, highly efficient gene expression could be observed in the knee joint transfected with the combination of BL and US exposure, compared to treatment with pDNA alone, pDNA plus BL, or pDNA plus US. The localized and prolonged gene expression was also shown by an in vivo luciferase imaging system. Thus, this local gene delivery system into joint synovium using the combination of BL and US exposure may be an effective means for gene therapy in joint disorders.

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