scholarly journals Potential role of IGF-1 in parathyroid hormone-related renal growth induced by high protein diet in uninephrectomized rats

1995 ◽  
Vol 48 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Joseph Caverzasio ◽  
T. Shigematsu ◽  
R. Rizzoli ◽  
Jean-Philippe Bonjour
Keyword(s):  
Parathyroid Hormone ◽  
Potential Role ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Renal Growth

scholarly journals Characterization of homocysteine metabolism in the rat liver

2000 ◽  
Vol 350 (3) ◽  
pp. 685-692 ◽  
Author(s):  
Lori M. STEAD ◽  
Margaret E. BROSNAN ◽  
John T. BROSNAN
Keyword(s):  
Amino Acid ◽  
Dietary Protein ◽  
High Protein Diet ◽  
Plasma Homocysteine ◽  
High Protein ◽  
Protein Diet ◽  
Total Plasma ◽  
Methionine Concentration ◽  
Protein Group

Recent evidence suggests that an increased plasma concentration of the sulphur amino acid homocysteine is a risk factor for the development of vascular disease. The tissue(s) responsible for homocysteine production and export to the plasma are not well known. However, given the central role of the liver in amino acid metabolism, we developed a rat primary hepatocyte model in which homocysteine (and cysteine) production and export were examined. The dependence of homocysteine export from incubated hepatocytes on methionine concentration fitted well to a rectangular hyperbola, with half-maximal homocysteine export achieved at methionine concentrations of approx. 0.44mM. Hepatocytes incubated with 1mM methionine and 1mM serine (a substrate for the transulphuration pathway of homocysteine removal) produced and exported significantly less homocysteine (25–40%) compared with cells incubated with 1mM methionine alone. The effects of dietary protein on homocysteine metabolism were also examined. Rats fed a 60% protein diet had a significantly increased total plasma homocysteine level compared with rats fed a 20% protein diet. Invitro effects of dietary protein were examined using hepatocytes isolated from animals maintained on these diets. When incubated with 1mM methionine, hepatocytes from rats fed the high protein diet exported significantly more homocysteine compared with hepatocytes from rats fed the normal protein diet. Inclusion of serine significantly lowered homocysteine export in the normal protein group, but the effect was more marked in the high protein group. Invivo effects of serine were also examined. Rats fed a high protein diet enriched with serine had significantly lower total plasma homocysteine (25–30%) compared with controls. These data indicate a significant role for the liver in the regulation of plasma homocysteine levels.

scholarly journals Liver GCN2 controls hepatic FGF21 secretion and modulates whole body postprandial oxidation profile under a low-protein diet

2019 ◽  
Vol 317 (6) ◽  
pp. E1015-E1021 ◽  
Author(s):  
Tristan Chalvon-Demersay ◽  
Joanna Moro ◽  
Patrick C. Even ◽  
Catherine Chaumontet ◽  
Daniel Tomé ◽  
...  
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Whole Body ◽  
Low Protein ◽  
The One ◽  
High Level ◽  
High Protein Diets

General control nonderepressible 2 (GCN2) is a kinase that detects amino acid deficiency and is involved in the control of protein synthesis and energy metabolism. However, the role of hepatic GCN2 in the metabolic adaptations in response to the modulation of dietary protein has been seldom studied. Wild-type (WT) and liver GCN2-deficient (KO) mice were fed either a normo-protein diet, a low-protein diet, or a high-protein diet for 3 wk. During this period, body weight, food intake, and metabolic parameters were followed. In mice fed normo- and high-protein diets, GCN2 pathway in the liver is not activated in WT mice, leading to a similar metabolic profile with the one of KO mice. On the contrary, a low-protein diet activates GCN2 in WT mice, inducing FGF21 secretion. In turn, FGF21 maintains a high level of lipid oxidation, leading to a different postprandial oxidation profile compared with KO mice. Hepatic GCN2 controls FGF21 secretion under a low-protein diet and modulates a whole body postprandial oxidation profile.

The role of calcitonin as the mediator of renal haemodynamic changes induced by the high protein diet

1985 ◽  
Vol 13 (1) ◽  
pp. 81
Author(s):  
S.F. Lui ◽  
Z. Varghese ◽  
K.K. Pun ◽  
P. Sweny ◽  
J.F. Moorhead
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Haemodynamic Changes

Comprehensive Profiling of the Circulatory miRNAome Response to a High Protein Diet in Elderly Men: A Potential Role in Inflammatory Response Modulation

2019 ◽  
Vol 63 (8) ◽  
pp. 1800811 ◽  
Author(s):  
Farha Ramzan ◽  
Cameron J. Mitchell ◽  
Amber M. Milan ◽  
William Schierding ◽  
Nina Zeng ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Potential Role ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Response Modulation ◽  
Elderly Men

scholarly journals The Role of Hepatic AMPK in Metabolic Adaptation under High‐Protein Diet

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Tristan Chalvon‐Demersay ◽  
Patrick Even ◽  
Benoit Viollet ◽  
Catherine Chaumontet ◽  
Daniel Tomé ◽  
...  
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Metabolic Adaptation

High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases

2010 ◽  
Vol 299 (5) ◽  
pp. R1263-R1268 ◽  
Author(s):  
Johan Sällström ◽  
Mattias Carlström ◽  
Johan Olerud ◽  
Bertil B. Fredholm ◽  
Mattias Kouzmine ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Knockout Mice ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Tubuloglomerular Feedback ◽  
Glomerular Hyperfiltration ◽  
Similar Degree ◽  
Nos Isoforms

A high protein intake is associated with increased glomerular filtration rate (GFR), which has been suggested to be mediated by reduced signaling of the tubuloglomerular feedback (TGF) mechanism. Nitric oxide (NO) has been shown to contribute to high protein-induced glomerular hyperfiltration, but the specific NO synthase (NOS) isoform responsible is not clear. In this study, a model for high-protein-induced hyperfiltration in conscious mice was developed. Using this model, we investigated the role of TGF using adenosine A1-receptor knockout mice lacking the TGF mechanism. Furthermore, the role of the different NOS isoforms was studied using neuronal-, inducible-, and endothelial-NOS knockout mice, and furthermore, wild-type mice acutely administered with the unspecific NOS inhibitor Nω-nitro-l-arginine methyl ester (100 mg/kg). GFR was measured consecutively in mice given a low-protein diet (8% casein) for 10 days, followed by a high-protein diet (50% casein) for 10 days. All mice developed high protein-induced hyperfiltration to a similar degree. These results demonstrate that high protein-induced glomerular hyperfiltration is independent of the TGF mechanism and NOS isoforms.

scholarly journals The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle

1978 ◽  
Vol 176 (2) ◽  
pp. 623-626 ◽  
Author(s):  
E A Newsholme ◽  
T Williams
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Malate Dehydrogenase ◽  
Amino Acid Metabolism ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Acid Metabolism ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

Starvation or feeding rats on a high-protein diet, valine or isoleucine, but not leucine, increases the activity of muscle phosphoenolpyruvate carboxykinase, but has no effect on NADP+-linked malate dehydrogenase. This suggests that muscle phosphoenolpyruvate carboxykinase is involved in oxidation or conversion of some amino acids to alanine.

Role of the pancreas in reduction of fecal fat and cholesterol by dietary protein

1960 ◽  
Vol 198 (2) ◽  
pp. 354-356
Author(s):  
L. Fragola ◽  
D. F. Magee
Keyword(s):  
Dietary Protein ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Pancreatic Ducts ◽  
Casein Diet ◽  
Low Protein ◽  
Fecal Fat ◽  
Fecal Cholesterol

Rats with separation of the pancreatic ducts and sham-operated controls were fed 8% and 30% casein diet. The fecal fats were lowered by the high-protein diet in each case. The magnitude of the decrease was not different in the two groups. The experiment was repeated with the addition of 2% cholesterol to the two diets. Both groups of animals while on the high-protein diet had less fecal cholesterol than when on the low-protein regimen.

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