scholarly journals Front cover: Comprehensive Profiling of the Circulatory miRNAome Response to a High Protein Diet in Elderly Men: A Potential Role in Inflammatory Response Modulation

2019 ◽  
Vol 63 (8) ◽  
pp. 1970019
Author(s):  
Farha Ramzan ◽  
Cameron J. Mitchell ◽  
Amber M. Milan ◽  
William Schierding ◽  
Nina Zeng ◽  
...  
2019 ◽  
Vol 63 (8) ◽  
pp. 1800811 ◽  
Author(s):  
Farha Ramzan ◽  
Cameron J. Mitchell ◽  
Amber M. Milan ◽  
William Schierding ◽  
Nina Zeng ◽  
...  

2020 ◽  
Vol Volume 15 ◽  
pp. 953-967
Author(s):  
Wolfgang Kemmler ◽  
Simon von Stengel ◽  
Matthias Kohl ◽  
Nicolas Rohleder ◽  
Thomas Bertsch ◽  
...  

1995 ◽  
Vol 48 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Joseph Caverzasio ◽  
T. Shigematsu ◽  
R. Rizzoli ◽  
Jean-Philippe Bonjour

2008 ◽  
Vol 67 (OCE5) ◽  
Author(s):  
F. Vitari ◽  
A. Morise ◽  
M. Formal ◽  
C. Garcia ◽  
K. Mace ◽  
...  

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 180
Author(s):  
Kouki Shimizu ◽  
Issei Seiki ◽  
Yoshiyuki Goto ◽  
Takeshi Murata

The intestinal pH can greatly influence the stability and absorption of oral drugs. Therefore, knowledge of intestinal pH is necessary to understand the conditions for drug delivery. This has previously been measured in humans and rats. However, information on intestinal pH in mice is insufficient despite these animals being used often in preclinical testing. In this study, 72 female ICR mice housed in SPF (specific pathogen-free) conditions were separated into nine groups to determine the intestinal pH under conditions that might cause pH fluctuations, including high-protein diet, ageing, proton pump inhibitor (PPI) treatment, several antibiotic treatment regimens and germ-free mice. pH was measured in samples collected from the ileum, cecum and colon, and compared to control animals. An electrode, 3 mm in diameter, enabled accurate pH measurements with a small amount of gastrointestinal content. Consequently, the pH values in the cecum and colon were increased by high-protein diet, and the pH in the ileum was decreased by PPI. Drastic alkalization was induced by antibiotics, especially in the cecum and colon. The alkalized pH values in germ-free mice suggested that the reduction in the intestinal bacteria caused by antibiotics led to alkalization. Alkalization of the intestinal pH caused by antibiotic treatment was verified in mice. We need further investigations in clinical settings to check whether the same phenomena occur in patients.


2016 ◽  
Vol 146 (3) ◽  
pp. 474-483 ◽  
Author(s):  
Chunlong Mu ◽  
Yuxiang Yang ◽  
Zhen Luo ◽  
Leluo Guan ◽  
Weiyun Zhu

1991 ◽  
Vol 62 (7) ◽  
pp. 628-635
Author(s):  
Masayuki FUNABA ◽  
Hajime NABETA ◽  
Hideo YANO ◽  
Ryoji KAWASHIMA

Sign in / Sign up

Export Citation Format

Share Document