scholarly journals Oxidant stress following renal ischemia: Changes in the glutathione redox ratio

1988 ◽  
Vol 33 (4) ◽  
pp. 812-817 ◽  
Author(s):  
Robert N. Mccoy ◽  
Kristina E. Hill ◽  
Mary A. Ayon ◽  
Jay H. Stein ◽  
Raymond F. Burk
Keyword(s):  
Oxidant Stress ◽  
Renal Ischemia ◽  
Redox Ratio ◽  
Glutathione Redox ◽  
Glutathione Redox Ratio

Oxygen consumption and oxidant stress in surviving nephrons

1990 ◽  
Vol 258 (5) ◽  
pp. F1354-F1362 ◽  
Author(s):  
K. A. Nath ◽  
A. J. Croatt ◽  
T. H. Hostetter
Keyword(s):  
Oxygen Consumption ◽  
Urinary Excretion ◽  
Dietary Protein ◽  
Protein Intake ◽  
Oxidant Stress ◽  
Dietary Protein Intake ◽  
Redox Ratio ◽  
Glutathione Redox ◽  
Standard Protein ◽  
Glutathione Redox Ratio

We investigated the effects of reduction of renal mass on rates of oxygen consumption, sodium transport, and indexes of oxidant stress in surviving nephrons. Rates of oxygen consumption in surviving nephrons were elevated by more than twofold compared with nephrons in intact kidneys in rats on standard protein intakes. Absolute rates of sodium reabsorption (TNa) in the surviving nephrons were increased with a lower ratio of TNa to oxygen consumption. To determine oxidant stress, we measured malondialdehyde (MDA) in the kidney and urine and the glutathione redox ratio in kidney tissue. MDA per nephron was increased in the subtotally nephrectomized model and was accompanied by increased absolute and fractional urinary excretion of MDA but not by an increase in kidney MDA per milligram protein. The glutathione redox ratios were similar. Since increased dietary protein intake worsens renal injury, we studied the effects of dietary protein manipulation (30 vs. 6%) on oxygen consumption, MDA levels, and the glutathione redox ratio. The kidneys of subtotally nephrectomized animals maintained on 30% protein diets exhibited increased rates of oxygen consumption. Increased dietary protein intake led to increased MDA per nephron, increased urinary excretion of MDA, and increased MDA per milligram protein in subtotally nephrectomized animals, and markedly increased the glutathione redox ratio. We conclude that, despite increased oxygen consumption, surviving nephrons compared with intact nephrons in rats on standard protein intake demonstrate no evidence of oxidant stress. Increased urinary clearance of MDA may provide a mechanism that prevents the buildup of lipid peroxidation. Subjecting the remnant nephron to increased protein increases oxygen consumption and imposes oxidant stress.(ABSTRACT TRUNCATED AT 250 WORDS)

Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells

2002 ◽  
Vol 957 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Marta Barrachina ◽  
Julio Secades ◽  
Rafael Lozano ◽  
Cristina Gómez-Santos ◽  
Santiago Ambrosio ◽  
...  
Keyword(s):  
Cell Death ◽  
Caspase 3 ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Redox Ratio ◽  
Glutathione Redox ◽  
Glutathione Redox Ratio

Nickel sulphate and epoxy resin: differences in iron status and glutathione redox ratio at the time of patch testing

2004 ◽  
Vol 295 (12) ◽  
pp. 517-520 ◽  
Author(s):  
Sirje Kaur ◽  
Mihkel Zilmer ◽  
Maigi Eisen ◽  
Aune Rehema ◽  
Tiiu Kullisaar ◽  
...  
Keyword(s):  
Epoxy Resin ◽  
Patch Testing ◽  
Iron Status ◽  
Nickel Sulphate ◽  
Redox Ratio ◽  
Glutathione Redox ◽  
Glutathione Redox Ratio

scholarly journals A Low Glutathione Redox State Couples with a Decreased Ascorbate Redox Ratio to Accelerate Flowering inOncidiumOrchid

2016 ◽  
Vol 57 (2) ◽  
pp. 423-436 ◽  
Author(s):  
Dan-Chu Chin ◽  
Chia-Chi Hsieh ◽  
Hsin-Yi Lin ◽  
Kai-Wun Yeh
Keyword(s):  
Redox State ◽  
Redox Ratio ◽  
Glutathione Redox

Oxidant Stress: The Role of the Glutathione Redox Cycle in Skin Preconditioning

1995 ◽  
Vol 58 (4) ◽  
pp. 395-400 ◽  
Author(s):  
Riley S. Rees ◽  
David J. Smith ◽  
Belinda Adamson ◽  
Michael Im ◽  
Daniel Hinshaw
Keyword(s):  
Oxidant Stress ◽  
Redox Cycle ◽  
Glutathione Redox Cycle ◽  
Glutathione Redox

Platelets attenuate oxidant-induced permeability in endothelial monolayers: glutathione-dependent mechanisms

1996 ◽  
Vol 81 (4) ◽  
pp. 1701-1706 ◽  
Author(s):  
Charlie Strange ◽  
Andrew Gottehrer ◽  
Karen Birmingham ◽  
John E. Heffner
Keyword(s):  
Glucose Oxidase ◽  
Oxidant Stress ◽  
Buthionine Sulfoximine ◽  
Human Platelets ◽  
Protective Effects ◽  
Redox Cycle ◽  
Endothelial Monolayers ◽  
Glutathione Redox Cycle ◽  
Monolayer Permeability ◽  
Glutathione Redox

Strange, Charlie, Andrew Gottehrer, Karen Birmingham, and John E. Heffner. Platelets attenuate oxidant-induced permeability in endothelial monolayers: glutathione-dependent mechanisms. J. Appl. Physiol. 81(4): 1701–1706, 1996.—We studied the effects of adding washed human platelets or platelets with nonintact glutathione redox cycles to endothelial cell monolayers treated with glucose oxidase to initiate oxidant stress and increase permeability. Changes in125I-labeled albumin transmonolayer movement were used as the index of monolayer permeability. Washed human platelets attenuated oxidant-induced increases in albumin flux. Platelets treated with 1,3-bis(2-chloroethyl)-1-nitrosurea, 1-chloro-2,4-dinitrobenzene, or buthionine sulfoximine to inhibit selective enzymatic steps in the glutathione redox cycle decreased permeability to a lesser degree. We conclude that 1) washed human platelets attenuate monolayer permeability defects in aortic endothelial monolayers exposed to glucose oxidase and 2) the protective effects of platelets are partially dependent on an intact platelet glutathione redox cycle.

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