scholarly journals Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

2015 ◽  
Vol 135 (8) ◽  
pp. 2129-2132 ◽  
Author(s):  
Nathan J. Hawkshaw ◽  
Iain S. Haslam ◽  
David M. Ansell ◽  
Asim Shamalak ◽  
Ralf Paus
Keyword(s):  
Cyclosporine A ◽  
Hair Growth ◽  
Scalp Hair ◽  
Hair Follicles ◽  
Human Scalp Hair ◽  
Growth Promoting

scholarly journals Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

PLoS Biology ◽  
2018 ◽  
Vol 16 (5) ◽  
pp. e2003705 ◽  
Author(s):  
Nathan J. Hawkshaw ◽  
Jonathan A. Hardman ◽  
Iain S. Haslam ◽  
Asim Shahmalak ◽  
Amos Gilhar ◽  
...  
Keyword(s):  
Hair Loss ◽  
Cyclosporine A ◽  
Human Hair ◽  
Scalp Hair ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Human Scalp Hair ◽  
Wnt Inhibitor

scholarly journals Evaluation of hair growth promoting activity of petroleum ether extract of Abrus precatorius Linn. on Wistar Albino rats

2019 ◽  
Vol 9 (2) ◽  
pp. 330-335
Author(s):  
Namrata Omhare ◽  
Pratibha Sahu ◽  
Shailee Gautam ◽  
Nidhi Jain
Keyword(s):  
Petroleum Ether ◽  
Hair Growth ◽  
Petroleum Ether Extract ◽  
Hair Follicles ◽  
Ether Extract ◽  
Standard Drug ◽  
Abrus Precatorius ◽  
Growth Initiation ◽  
Growth Promoting ◽  
Bald Patch

In present investigation was carried out to screening of hair growth promoting potentiality of petroleum ether extract of Abrus precatorius leaf. Preliminary chemical tests and TLC analysis revealed the presence flavonoids and saponins. Hair growth promoting activity of petroleum ether of Abrus precatorius was screened by considering different parameters which included time taken for covering bald patch, length of hair produced, percentage of hair follicles in anagen and telogen phases, time of hair growth initiation and completion and level of minerals in blood. The petroleum ether extract of Abrus precatorius showed a very good hair growth promoting activity at a dose of 300 mg/kg which was comparable to that of 2% minoxidil. After 30 days of treatment with test and standard drugs it was observed that, time taken for covering the bald patch, hair growth initiation and completion time and quantitative hair growth were found to be comparable to that of the standard drug. An increase in percentage of hair follicles turning from telogen phase to anagen phase was noted. The control treated group of animals showed poor hair growth for all the parameters. Keywords: Abrus precatorius Linn, Anagen, Catagen, Telogen, Minoxidil

scholarly journals Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

2006 ◽  
Vol 168 (3) ◽  
pp. 748-756 ◽  
Author(s):  
Kerstin Foitzik ◽  
Karoline Krause ◽  
Franziska Conrad ◽  
Motonobu Nakamura ◽  
Wolfang Funk ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Scalp Hair ◽  
Hair Follicles ◽  
Human Scalp Hair

scholarly journals Estrogens and Human Scalp Hair Growth—Still More Questions than Answers

2004 ◽  
Vol 122 (3) ◽  
pp. 840-842 ◽  
Author(s):  
Franziska Conrad ◽  
Ulrich Ohnemus ◽  
Enikö Bodo ◽  
Albrecht Bettermann ◽  
Ralf Paus
Keyword(s):  
Hair Growth ◽  
Scalp Hair ◽  
Human Scalp Hair

scholarly journals Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using - FTIR-ATR Spectroscopy

2019 ◽  
Author(s):  
Padmavathi R ◽  
Gunasekaran S ◽  
Rajamannan B ◽  
Ramkumar GR ◽  
Sankari G ◽  
...  
Keyword(s):  
Scalp Hair ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Pilosebaceous Unit ◽  
Tissue Samples ◽  
Spectral Signatures ◽  
Human Scalp Hair ◽  
Chronic Skin ◽  
Noninvasive Sample ◽  
Atr Spectroscopy

Acne vulgaris is a chronic skin disease which occurs due to inflammation of the hair follicles and sebum-producing (sebaceous) glands of the skin called pilosebaceous unit and the anaerobic propionic acne bacterium, P.acne. Human sebum is dominantly made up of 57.5% of triglycerides and fatty acids, 26%wax esters, 12% Squalene and 4.5% Cholesterol. The increased level Androgen hormone, sebum lipid composition, P.acne overgrowth which induces monocytes and pro-inflammatory cytokines attract neutrophils, basophils, and T cells to the pilosebaceous unit and drive epithelial hyperproliferation i.e., Acne vulgaris. The actual biomolecular changes due to acne vulgaris disease are present in the blood and in the sebum and also in the noninvasive sample of human scalp hair follicles. The main objectives of the present study are to analyze human scalp hair follicles samples using FTIR-ATR spectroscopy to compare and discriminate the spectral signatures of acne vulgaris and healthy scalp hair tissue samples through acne bio-markers Protein, Amide I, Amide II and Squalene (LDL), using the method of internal ratio parameters.

Evidence for Alpha-MSH Binding Sites on Human Scalp Hair Follicles: Preliminary Results

1991 ◽  
Vol 4 (4) ◽  
pp. 193-198 ◽  
Author(s):  
P.B. NANNINGA ◽  
G.E. GHANEM ◽  
F.J. LEJEUNE ◽  
J.D. BOS ◽  
W. WESTERHOF
Keyword(s):  
Binding Sites ◽  
Scalp Hair ◽  
Hair Follicles ◽  
Preliminary Results ◽  
Human Scalp Hair

scholarly journals Extract ofAllium tuberosum Rottler ex SprengPromoted the Hair Growth through Regulating the Expression of IGF-1

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Ki Moon Park ◽  
Dong Woo Kim ◽  
Seung Ho Lee
Keyword(s):  
Growth Factor ◽  
Hair Growth ◽  
Control Mouse ◽  
Ethanol Extract ◽  
Insoluble Fraction ◽  
Hair Follicles ◽  
Gel Chromatography ◽  
Skin Area ◽  
Dorsal Skin ◽  
Growth Promoting

Allium tuberosum Rottler ex Spreng(ATRES) has been used as a traditional medicine for the treatment of abdominal pain, diarrhea, and asthma. In this study, we investigated the hair growth promoting activities of ATRES on telogenic C57BL6/N mice. Hair growth was significantly increased in the dorsal skin of ethanol extract of ATRES treated mouse group compared with the control mouse group. To enrich the hair promoting activity, an ethanol-insoluble fraction was further extracted in sequence withn-hexane, dichloromethane, ethyl acetate,n-butanol, and distilled water. Interestingly, we found that extraction withn-butanol is most efficient in producing the hair promoting activity. In addition, the soluble fraction of then-butanol extract was further separated by silica gel chromatography and thin layer chromatography (TLC) resulting in isolating four single fractions which have hair growth regeneration potential. Furthermore, administration of ATRES extracts to dorsal skin area increased the number of hair follicles compared with control mouse group. Interestingly, administration of ATRES extract stimulated the expression of insulin-like growth factor-1 (IGF-1) but not of keratin growth factor (KGF) or vascular endothelial growth factor (VEGF). Taken together, these results suggest that ATRES possesses strong hair growth promoting potential which controls the expression of IGF-1.

Protein biosynthesis in isolated human scalp hair follicles

1978 ◽  
Vol 4 (4) ◽  
pp. 211-216 ◽  
Author(s):  
A. J. M. Vermorken ◽  
P. J. J. M. Weterings ◽  
H. Bloemendal
Keyword(s):  
Scalp Hair ◽  
Protein Biosynthesis ◽  
Hair Follicles ◽  
Human Scalp Hair
Sign in / Sign up

Export Citation Format

Share Document