scholarly journals Regulatory T Cells from IL-10-Deficient Mice Fail to Suppress Contact Hypersensitivity Reactions Due to Lack of Adenosine Production

2011 ◽  
Vol 131 (7) ◽  
pp. 1494-1502 ◽  
Author(s):  
Sabine Ring ◽  
Alexander H. Enk ◽  
Karsten Mahnke
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Deficient Mice

Expanded murine regulatory T cells: Analysis of phenotype and function in contact hypersensitivity reactions

2007 ◽  
Vol 326 (1-2) ◽  
pp. 10-21 ◽  
Author(s):  
Sabine Ring ◽  
Marianne Thome ◽  
Leah Pretsch ◽  
Alexander H. Enk ◽  
Karsten Mahnke
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
And Function

scholarly journals Down-Regulation of CD62L Shedding in T Cells by CD39+ Regulatory T Cells Leads to Defective Sensitization in Contact Hypersensitivity Reactions

2017 ◽  
Vol 137 (1) ◽  
pp. 106-114 ◽  
Author(s):  
Karsten Mahnke ◽  
Jurgina Useliene ◽  
Sabine Ring ◽  
Paula Kage ◽  
Verena Jendrossek ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Down Regulation

scholarly journals Prevention of UV radiation–induced immunosuppression by IL-12 is dependent on DNA repair

2005 ◽  
Vol 201 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Agatha Schwarz ◽  
Akira Maeda ◽  
Kerstin Kernebeck ◽  
Harry van Steeg ◽  
Stefan Beissert ◽  
...  
Keyword(s):  
T Cells ◽  
Dna Repair ◽  
Regulatory T Cells ◽  
Uv Radiation ◽  
Contact Hypersensitivity ◽  
Immune Restoration ◽  
Radiation Induced ◽  
Induced Tolerance ◽  
Deficient Mice ◽  
Solar Ultraviolet

The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by solar/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was recently found to induce deoxyribonucleic acid (DNA) repair. UV-induced DNA damage is an important molecular trigger for UV-mediated immunosuppression. Thus, we initiated studies into immune restoration by IL-12 to discern whether its effects are linked to DNA repair. IL-12 prevented both UV-induced suppression of the induction of contact hypersensitivity and the depletion of Langerhans cells, the primary APC of the skin, in wild-type but not in DNA repair-deficient mice. IL-12 did not prevent the development of UV-induced regulatory T cells in DNA repair-deficient mice. In contrast, IL-12 was able to break established UV-induced tolerance and inhibited the activity of regulatory T cells independent of DNA repair. These data identify a new mechanism by which IL-12 can restore immune responses and also demonstrate a link between DNA repair and the prevention of UV-induced immunosuppression by IL-12.

CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism

2009 ◽  
Vol 123 (6) ◽  
pp. 1287-1296.e2 ◽  
Author(s):  
Sabine Ring ◽  
Stephen J. Oliver ◽  
Bruce N. Cronstein ◽  
Alexander H. Enk ◽  
Karsten Mahnke
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Dependent Mechanism

scholarly journals ATP Activates Regulatory T Cells In Vivo during Contact Hypersensitivity Reactions

2010 ◽  
Vol 184 (7) ◽  
pp. 3408-3416 ◽  
Author(s):  
Sabine Ring ◽  
Alexander H. Enk ◽  
Karsten Mahnke
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions

scholarly journals CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue

2006 ◽  
Vol 36 (11) ◽  
pp. 2981-2992 ◽  
Author(s):  
Sabine Ring ◽  
Stephan C. Schäfer ◽  
Karsten Mahnke ◽  
Hans-Anton Lehr ◽  
Alexander H. Enk
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Effector T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Inflamed Tissue

Pioglitazone modulates the balance of effector and regulatory T cells in apolipoprotein E deficient mice☆

2011 ◽  
Vol 21 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Y. Tian ◽  
Z. Yuan ◽  
Y. Liu ◽  
W. Liu ◽  
W. Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Apolipoprotein E ◽  
Deficient Mice
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