scholarly journals CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue

2006 ◽  
Vol 36 (11) ◽  
pp. 2981-2992 ◽  
Author(s):  
Sabine Ring ◽  
Stephan C. Schäfer ◽  
Karsten Mahnke ◽  
Hans-Anton Lehr ◽  
Alexander H. Enk
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Effector T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Inflamed Tissue

Expanded murine regulatory T cells: Analysis of phenotype and function in contact hypersensitivity reactions

2007 ◽  
Vol 326 (1-2) ◽  
pp. 10-21 ◽  
Author(s):  
Sabine Ring ◽  
Marianne Thome ◽  
Leah Pretsch ◽  
Alexander H. Enk ◽  
Karsten Mahnke
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
And Function

Juzentaihoto Exerts Anti-Allergic Effects by Inhibiting Effector T-Cell Activation and Inducing and/or Activating Regulatory T Cells in a Murine Model of Contact Hypersensitivity

2021 ◽  
pp. 1-13
Author(s):  
Atsushi Tsuge ◽  
Sho Yonekura ◽  
Satomi Watanabe ◽  
Yuta Kurosaki ◽  
Shinsuke Hisaka ◽  
...  
Keyword(s):  
T Cells ◽  
Monoclonal Antibodies ◽  
T Cell ◽  
Regulatory T Cells ◽  
T Cell Activation ◽  
Cell Activation ◽  
Effector T Cells ◽  
Contact Hypersensitivity ◽  
Dependent Manner ◽  
Effector T Cell

<b><i>Background:</i></b> Juzentaihoto (JTT) is a Kampo prescription that has been used clinically for treating skin diseases such as atopic dermatitis in Japan. We have previously studied the anti-allergic effects of JTT on 2,4,6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity (CHS) in mice and demonstrated that it significantly suppresses ear swelling in a dose-dependent manner. However, the mechanism underlying the anti-allergic actions of JTT is obscure. <b><i>Methods:</i></b> We investigated the mechanism underlying the anti-allergic effects of JTT using a TNCB-induced murine CHS model and adoptive cell transfer experiments. <b><i>Results:</i></b> We showed that the anti-allergic effects of JTT are due to inhibition of effector T-cell activation and induction and/or activation of regulatory T cells. Furthermore, ex vivo experiments confirmed the effect of JTT on the activation of effector T cells and regulatory T cells, as interferon-γ production decreased, whereas interleukin (IL)-10 production increased, in the cultured lymphocytes obtained from 5% TNCB-sensitized mice treated with anti-CD3ε and anti-CD28 monoclonal antibodies. Flow cytometry showed that the CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>, CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>−</sup>, and CD8<sup>+</sup>CD122<sup>+</sup> cell population increased after oral administration of JTT. Finally, the anti-allergic effect of JTT by inducing and/or activating regulatory T cells (Tregs) was confirmed to be mediated by IL-10 through in vivo neutralization experiments with anti-IL-10 monoclonal antibodies. <b><i>Conclusion:</i></b> We suggested that JTT exerts anti-allergic effects by regulating the activation of effector T cells and Tregs involved in murine CHS model.

scholarly journals Down-Regulation of CD62L Shedding in T Cells by CD39+ Regulatory T Cells Leads to Defective Sensitization in Contact Hypersensitivity Reactions

2017 ◽  
Vol 137 (1) ◽  
pp. 106-114 ◽  
Author(s):  
Karsten Mahnke ◽  
Jurgina Useliene ◽  
Sabine Ring ◽  
Paula Kage ◽  
Verena Jendrossek ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Down Regulation

CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism

2009 ◽  
Vol 123 (6) ◽  
pp. 1287-1296.e2 ◽  
Author(s):  
Sabine Ring ◽  
Stephen J. Oliver ◽  
Bruce N. Cronstein ◽  
Alexander H. Enk ◽  
Karsten Mahnke
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions ◽  
Dependent Mechanism

scholarly journals ATP Activates Regulatory T Cells In Vivo during Contact Hypersensitivity Reactions

2010 ◽  
Vol 184 (7) ◽  
pp. 3408-3416 ◽  
Author(s):  
Sabine Ring ◽  
Alexander H. Enk ◽  
Karsten Mahnke
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Contact Hypersensitivity ◽  
Hypersensitivity Reactions

scholarly journals Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance

2009 ◽  
Vol 21 (4) ◽  
pp. 379-391 ◽  
Author(s):  
Kanji Nagahama ◽  
Zoltan Fehervari ◽  
Takatoku Oida ◽  
Tomoyuki Yamaguchi ◽  
Osamu Ogawa ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Effector T Cells ◽  
Transplantation Tolerance ◽  
Differential Control
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