scholarly journals The Impact of In Vivo Reflectance Confocal Microscopy on the Diagnostic Accuracy of Lentigo Maligna and Equivocal Pigmented and Nonpigmented Macules of the Face

2010 ◽  
Vol 130 (8) ◽  
pp. 2080-2091 ◽  
Author(s):  
Pascale Guitera ◽  
Giovanni Pellacani ◽  
Kerry A. Crotty ◽  
Richard A. Scolyer ◽  
Ling-Xi L. Li ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Diagnostic Accuracy ◽  
Reflectance Confocal Microscopy ◽  
Lentigo Maligna ◽  
The Face ◽  
The Impact

The Impact of In Vivo Reflectance Confocal Microscopy for the Diagnostic Accuracy of Melanoma and Equivocal Melanocytic Lesions

2007 ◽  
Vol 127 (12) ◽  
pp. 2759-2765 ◽  
Author(s):  
Giovanni Pellacani ◽  
Pascale Guitera ◽  
Caterina Longo ◽  
Michelle Avramidis ◽  
Stefania Seidenari ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Diagnostic Accuracy ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions ◽  
The Impact

scholarly journals Comparing preoperative mapping with reflectance confocal microscopy to surgical markings in lentigo maligna excision of the face: a pilot study

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Lipi Shukla ◽  
Louise Photiou ◽  
Alan Pham ◽  
Catriona McLean ◽  
Raquel Ruiz ◽  
...  
Keyword(s):  
Pilot Study ◽  
Confocal Microscopy ◽  
Surgical Margin ◽  
Surgical Excision ◽  
Reflectance Confocal Microscopy ◽  
Histopathological Analysis ◽  
Lentigo Maligna ◽  
Complete Excision ◽  
Preoperative Mapping

Background: Lentigo maligna (LM) characteristically has an ill-defined margin and may require multiple excisions to achieve complete excision with 5mm margins. In vivo reflectance confocal microscopy (RCM) is a non-invasive tool recognised as useful in the management of LM. The authors aimed to determine whether the use of RCM prior to surgical excision reliably increased the rate of complete excision when compared with standard surgical excision. Methods: This prospective pilot study included patients with biopsy-proven LM of head and neck region who sought consultation for surgical management from May 2017 to May 2019 at the Victorian Melanoma Service, Melbourne. Patients were randomised to two groups based on the availability of RCM — Group 1, RCM-guided surgical excision, and Group 2, standard surgical excision. Outcomes were measured based on clinical markings and histopathological margins achieved and reported as RCM or surgical margin excess or deficit. Ethics approval for the study was obtained from the Research Governance Unit of The Alfred Hospital, Melbourne. Results: Results demonstrated that RCM marking of lesion margins was in excess in 69 percent of cases, in deficit in 22 per cent and accurate in nine per cent after histopathological analysis of the specimens. In comparison, lesions that were surgically marked were removed with margins in excess in 43 per cent of cases, in deficit in 11 per cent and accurate in 46 per cent. Conclusion: This pilot study demonstrates that RCM did not increase the accuracy of LM surgical excision in comparison with standard surgically marked excisions.

In Vivo Reflectance Confocal Microscopy to Optimize the Spaghetti Technique for Defining Surgical Margins of Lentigo Maligna

2014 ◽  
Vol 40 (3) ◽  
pp. 247-256 ◽  
Author(s):  
Julie Champin ◽  
Jean-Luc Perrot ◽  
Elisa Cinotti ◽  
Bruno Labeille ◽  
Catherine Douchet ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Surgical Margins ◽  
Reflectance Confocal Microscopy ◽  
Lentigo Maligna

scholarly journals Visualizing the in-vivo application of zinc in sensitive skin using reflectance confocal microscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hye-Jin Ahn ◽  
Hae Jin Kim ◽  
Hyein Ham ◽  
Ji Hwoon Baek ◽  
Young Lee ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Reflectance Confocal Microscopy ◽  
Sensitive Skin ◽  
The Face ◽  
Self Assessments ◽  
Different Depths ◽  
Imagej Software

AbstractFindings obtained on objective assessments to evaluate sensitive skin do not correlate well with the symptomatology. We utilized reflectance confocal microscopy (RCM) to compare transepidermal application of zinc in sensitive and non-sensitive skin. Thirty-six subjects participated in this study. They were divided into groups based on lactic acid sting test (LAST):‘stinger’ and ‘non-stinger’; transepidermal water loss (TEWL) measurements; and sensitivity self-assessments: ‘sensitive’ and ‘non-sensitive’. RCM images were taken to visualize transepidermal application of topically-applied zinc. The intensity of zinc reflectance at different depths was measured by ImageJ software. Based on LAST scores, the ‘stinger’ group showed significantly higher reflectance of zinc at 8 µm (stratum corneum) [face (P < 0.001), forearm (P = 0.004)], and at 80–104 µm (dermo-epidermal junction layer) on the face. High-TEWL group showed increased zinc reflectance at 8–24 µm (tight junction layer, P < 0.001). There were no significant differences amongst subjects self-reporting ‘sensitive’ and ‘non-sensitive’ skin. RCM demonstrates that in sensitive skin, there is deeper and higher reflectance of zinc at multiple depths. Structural differences are also visualized. We suggest that RCM is a useful tool for evaluating skin barrier integrity.

In vivo reflectance confocal microscopy to monitor the response of lentigo maligna to imiquimod

2014 ◽  
Vol 71 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Ivette Alarcon ◽  
Cristina Carrera ◽  
Llucia Alos ◽  
Josep Palou ◽  
Josep Malvehy ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Lentigo Maligna
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