scholarly journals The Calcium-Sensing Receptor-Dependent Regulation of Cell–Cell Adhesion and Keratinocyte Differentiation Requires Rho and Filamin A

2011 ◽  
Vol 131 (5) ◽  
pp. 1119-1128 ◽  
Author(s):  
Chia-Ling Tu ◽  
Wenhan Chang ◽  
Daniel D. Bikle
Keyword(s):  
Cell Adhesion ◽  
Keratinocyte Differentiation ◽  
Filamin A ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Cell Cell

scholarly journals Calcium-Sensing Receptor Activation Increases Cell-Cell Adhesion and ß-Cell Function

2012 ◽  
Vol 30 (3) ◽  
pp. 575-586 ◽  
Author(s):  
Claire E. Hills ◽  
Mustafa Y.G. Younis ◽  
Jeanette Bennett ◽  
Eleftherios Siamantouras ◽  
Kuo-Kang Liu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cell Function ◽  
Receptor Activation ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Cell Cell

scholarly journals The Role of MicroRNAs in Epidermal Barrier

2020 ◽  
Vol 21 (16) ◽  
pp. 5781
Author(s):  
Ai-Young Lee
Keyword(s):  
Cell Adhesion ◽  
Critical Role ◽  
Keratinocyte Differentiation ◽  
Epidermal Barrier ◽  
Barrier Integrity ◽  
Skin Lipids ◽  
Differentiation And Proliferation ◽  
The Impact ◽  
Cell Cell

MicroRNAs (miRNAs), which mostly cause target gene silencing via transcriptional repression and degradation of target mRNAs, regulate a plethora of cellular activities, such as cell growth, differentiation, development, and apoptosis. In the case of skin keratinocytes, the role of miRNA in epidermal barrier integrity has been identified. Based on the impact of key genetic and environmental factors on the integrity and maintenance of skin barrier, the association of miRNAs within epidermal cell differentiation and proliferation, cell–cell adhesion, and skin lipids is reviewed. The critical role of miRNAs in the epidermal barrier extends the use of miRNAs for control of relevant skin diseases such as atopic dermatitis, ichthyoses, and psoriasis via miRNA-based technologies. Most of the relevant miRNAs have been associated with keratinocyte differentiation and proliferation. Few studies have investigated the association of miRNAs with structural proteins of corneocytes and cornified envelopes, cell–cell adhesion, and skin lipids. Further studies investigating the association between regulatory and structural components of epidermal barrier and miRNAs are needed to elucidate the role of miRNAs in epidermal barrier integrity and their clinical implications.

scholarly journals Fucoidan from Undaria pinnatifida Ameliorates Epidermal Barrier Disruption via Keratinocyte Differentiation and CaSR Level Regulation

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 660
Author(s):  
Yu Chen ◽  
Xuenan Li ◽  
Xiaoshuang Gan ◽  
Junmei Qi ◽  
Biao Che ◽  
...  
Keyword(s):  
Undaria Pinnatifida ◽  
Keratinocyte Differentiation ◽  
Mechanistic Study ◽  
Calcium Sensing Receptor ◽  
Epidermal Barrier ◽  
Barrier Disruption ◽  
Calcium Sensing ◽  
External Agents ◽  
Proliferation And Differentiation ◽  
Barrier Repair

The epidermal barrier acts as a line of defense against external agents as well as helps to maintain body homeostasis. The calcium concentration gradient across the epidermal barrier is closely related to the proliferation and differentiation of keratinocytes (KCs), and the regulation of these two processes is the key to the repair of epidermal barrier disruption. In the present study, we found that fucoidan from Undaria pinnatifida (UPF) could promote the repair of epidermal barrier disruption in mice. The mechanistic study demonstrated that UPF could promote HaCaT cell differentiation under low calcium condition by up-regulating the expression of calcium-sensing receptor (CaSR), which could then lead to the activation of the Catenin/PLCγ1 pathway. Further, UPF could increase the expression of CaSR through activate the ERK and p38 pathway. These findings reveal the molecular mechanism of UPF in the repair of the epidermal barrier and provide a basis for the development of UPF into an agent for the repair of epidermal barrier repair.

Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation

2002 ◽  
Vol 192 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Laszlo Komuves ◽  
Yuko Oda ◽  
Chia-ling Tu ◽  
Wen Han Chang ◽  
Chrystal L. Ho-Pao ◽  
...  
Keyword(s):  
Extracellular Calcium ◽  
Full Length ◽  
Keratinocyte Differentiation ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Epidermal Expression

The extracellular calcium-sensing receptor and cell–cell signaling in epithelia

Cell Calcium ◽  
2004 ◽  
Vol 35 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Aldebaran M Hofer ◽  
Andrea Gerbino ◽  
Rosa Caroppo ◽  
Silvana Curci
Keyword(s):  
Cell Signaling ◽  
Extracellular Calcium ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Cell Cell

scholarly journals CALCIUM SENSING RECEPTOR DELETION IN THE MOUSE ESOPHAGUS ALTERS THE EXPRESSION OF CELL‐CELL JUNCTIONAL PROTEINS

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Solange Abdulnour‐Nakhoul ◽  
Chia‐Ling Tu ◽  
Jianwen Que ◽  
M Toriqul Islam ◽  
Karen Brown ◽  
...  
Keyword(s):  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Junctional Proteins ◽  
Cell Cell

scholarly journals The Calcium Sensing Receptor and Its Alternatively Spliced Form in Keratinocyte Differentiation

1998 ◽  
Vol 273 (36) ◽  
pp. 23344-23352 ◽  
Author(s):  
Yuko Oda ◽  
Chia-Ling Tu ◽  
Sreekumar Pillai ◽  
Daniel D. Bikle
Keyword(s):  
Keratinocyte Differentiation ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Alternatively Spliced

scholarly journals Interaction of the Calcium-sensing Receptor and Filamin, a Potential Scaffolding Protein

2001 ◽  
Vol 276 (37) ◽  
pp. 34871-34879 ◽  
Author(s):  
Hisataka Awata ◽  
Chunfa Huang ◽  
Mary E. Handlogten ◽  
R. Tyler Miller
Keyword(s):  
Scaffolding Protein ◽  
Filamin A ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

scholarly journals Calcium-sensing Receptor Modulates Cell Adhesion and Migration via Integrins

2011 ◽  
Vol 286 (47) ◽  
pp. 40922-40933 ◽  
Author(s):  
Sujeenthar Tharmalingam ◽  
Avais M. Daulat ◽  
Jordan E. Antflick ◽  
Syed M. Ahmed ◽  
Edward F. Nemeth ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Cell Adhesion And Migration ◽  
And Migration
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