scholarly journals Functional Redundancy of Langerhans Cells and Langerin+ Dermal Dendritic Cells in Contact Hypersensitivity

2010 ◽  
Vol 130 (12) ◽  
pp. 2752-2759 ◽  
Author(s):  
Madelon Noordegraaf ◽  
Vincent Flacher ◽  
Patrizia Stoitzner ◽  
Björn E. Clausen
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Functional Redundancy ◽  
Contact Hypersensitivity

scholarly journals Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity

2005 ◽  
Vol 169 (4) ◽  
pp. 569-576 ◽  
Author(s):  
Clare L. Bennett ◽  
Erwin van Rijn ◽  
Steffen Jung ◽  
Kayo Inaba ◽  
Ralph M. Steinman ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Steady State ◽  
Diphtheria Toxin ◽  
Langerhans Cells ◽  
Contact Hypersensitivity ◽  
Relative Importance ◽  
Skin Immunity

Langerhans cells (LC) form a unique subset of dendritic cells (DC) in the epidermis but so far their in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC (dDC). Here, we exploit a novel diphtheria toxin (DT) receptor (DTR)/DT-based system to achieve inducible ablation of LC without affecting the skin environment. Within 24 h after intra-peritoneal injection of DT into Langerin-DTR mice LC are completely depleted from the epidermis and only begin to return 4 wk later. LC deletion occurs by apoptosis in the absence of inflammation and, in particular, the dDC compartment is not affected. In LC-depleted mice contact hypersensitivity (CHS) responses are significantly decreased, although ear swelling still occurs indicating that dDC can mediate CHS when necessary. Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance.

Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity

2010 ◽  
Vol 125 (5) ◽  
pp. 1154-1156.e2 ◽  
Author(s):  
Tetsuya Honda ◽  
Saeko Nakajima ◽  
Gyohei Egawa ◽  
Kouetsu Ogasawara ◽  
Bernard Malissen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Contact Hypersensitivity ◽  
Sensitization Phase

Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to Macrophages

1980 ◽  
Vol 53 (1) ◽  
pp. 203-232 ◽  
Author(s):  
Inga Silbernirg-Sinakrn ◽  
Irma Gmlgli ◽  
Rudolf L. Balr ◽  
G. Jeanetth Thobecke
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Contact Hypersensitivity

Ratio of Langerhans Cells to Thy-1+ Dendritic Cells in Contact Hypersensitivity

1988 ◽  
Vol 90 (5) ◽  
pp. 770-771
Author(s):  
William R. Brown ◽  
Gulnar M. Shivji ◽  
Robert D. Furukawa ◽  
Colin A. Ramsay
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Contact Hypersensitivity

Dendritic cells of the human epidermis: immuno-electron microscopic studies of la antigen reactivity

1978 ◽  
Vol 36 (2) ◽  
pp. 644-645
Author(s):  
G. Rowden ◽  
M. G. Lewis ◽  
T. M. Phillips
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Cell Types ◽  
Cell Type ◽  
Electron Microscopic ◽  
La Antigen ◽  
Microscopic Studies ◽  
A Cell ◽  
C3 Receptors ◽  
Antigen Reactivity

Langerhans cells of mammalian stratified squamous epithelial have proven to be an enigma since their discovery in 1868. These dendritic suprabasal cells have been considered as related to melanocytes either as effete cells, or as post divisional products. Although grafting experiments seemed to demonstrate the independence of the cell types, much confusion still exists. The presence in the epidermis of a cell type with morphological features seemingly shared by melanocytes and Langerhans cells has been especially troublesome. This so called "indeterminate", or " -dendritic cell" lacks both Langerhans cells granules and melanosomes, yet it is clearly not a keratinocyte. Suggestions have been made that it is related to either Langerhans cells or melanocyte. Recent studies have unequivocally demonstrated that Langerhans cells are independent cells with immune function. They display Fc and C3 receptors on their surface as well as la (immune region associated) antigens.

scholarly journals Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 ◽  
Vol 163 (4) ◽  
pp. 981-997 ◽  
Author(s):  
G Kraal ◽  
M Breel ◽  
M Janse ◽  
G Bruin
Keyword(s):  
Monoclonal Antibody ◽  
Bone Marrow ◽  
Dendritic Cells ◽  
Dendritic Cell ◽  
Langerhans Cells ◽  
Precursor Cells ◽  
Peritoneal Exudate ◽  
Peritoneal Exudate Cells ◽  
Interdigitating Cells

An mAb, NLDC-145, is described that specifically reacts with a group of nonlymphoid dendritic cells including Langerhans cells (LC), veiled cells (VC), and interdigitating cells (IDC). The antibody does not react with precursor cells in bone marrow and blood. Macrophages are not stained by the antibody, but a subpopulation of Ia+ peritoneal exudate cells is recognized. Possible relationships of the various nonlymphoid dendritic cell (NLDC) types are discussed.

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