scholarly journals The Transcriptional Coactivator DRIP/Mediator Complex Is Involved in Vitamin D Receptor Function and Regulates Keratinocyte Proliferation and Differentiation

2010 ◽  
Vol 130 (10) ◽  
pp. 2377-2388 ◽  
Author(s):  
Yuko Oda ◽  
Robert J. Chalkley ◽  
Alma L. Burlingame ◽  
Daniel D. Bikle
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Mediator Complex ◽  
Transcriptional Coactivator ◽  
Receptor Function ◽  
Keratinocyte Proliferation ◽  
Proliferation And Differentiation

Vitamin D receptor, a tumor suppressor in skin

2015 ◽  
Vol 93 (5) ◽  
pp. 349-354 ◽  
Author(s):  
Daniel D. Bikle
Keyword(s):  
Vitamin D ◽  
Tumor Suppressor ◽  
Vitamin D Receptor ◽  
Tumor Formation ◽  
Calcium Sensing Receptor ◽  
Keratinocyte Proliferation ◽  
Calcium Sensing ◽  
Damage Repair ◽  
Proliferation And Differentiation ◽  
Active Investigation

Vitamin D and calcium are well-established regulators of keratinocyte proliferation and differentiation. Therefore, it was not a great surprise that deletion of the vitamin D receptor (VDR) should predispose the skin to tumor formation, and that the combination of deleting both the VDR and calcium sensing receptor (CaSR) should be especially pro-oncogenic. In this review I have examined 4 mechanisms that appear to underlie the means by which VDR acts as a tumor suppressor in skin. First, DNA damage repair is curtailed in the absence of the VDR, allowing mutations in DNA to accumulate. Second and third involve the increased activation of the hedgehog and β-catenin pathways in the epidermis in the absence of the VDR, leading to poorly regulated proliferation with reduced differentiation. Finally, VDR deletion leads to a shift in the expression of long noncoding RNAs toward a more oncogenic profile. How these different mechanisms interact and their relative importance in the predisposition of the VDR null epidermis to tumor formation remain under active investigation.

Normal vitamin D receptor function with increased expression of 25-hydroxyvitamin D3-24-hydroxylase in Corriedale sheep with inherited rickets

2011 ◽  
Vol 91 (3) ◽  
pp. 362-369 ◽  
Author(s):  
K.E. Dittmer ◽  
L. Howe ◽  
K.G. Thompson ◽  
K.M. Stowell ◽  
H.T. Blair ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Function ◽  
Normal Vitamin

scholarly journals 1α, 25-Dihydroxyvitamin D3 and the vitamin D receptor regulates ΔNp63α levels and keratinocyte proliferation

2015 ◽  
Vol 6 (6) ◽  
pp. e1781-e1781 ◽  
Author(s):  
N T Hill ◽  
J Zhang ◽  
M K Leonard ◽  
M Lee ◽  
H N Shamma ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
Keratinocyte Proliferation

scholarly journals Analysis of the Molecular Mechanism for the Antagonistic Action of a Novel 1α,25-Dihydroxyvitamin D3Analogue toward Vitamin D Receptor Function

1999 ◽  
Vol 274 (45) ◽  
pp. 32376-32381 ◽  
Author(s):  
Keiichi Ozono ◽  
Mariko Saito ◽  
Daishiro Miura ◽  
Toshimi Michigami ◽  
Shigeo Nakajima ◽  
...  
Keyword(s):  
Vitamin D ◽  
Molecular Mechanism ◽  
Vitamin D Receptor ◽  
Receptor Function ◽  
Antagonistic Action

scholarly journals Positive and Negative Modulation of Vitamin D Receptor Function by Transforming Growth Factor-β Signaling through Smad Proteins

1999 ◽  
Vol 274 (19) ◽  
pp. 12971-12974 ◽  
Author(s):  
Yasuo Yanagi ◽  
Miyuki Suzawa ◽  
Masahiro Kawabata ◽  
Kohei Miyazono ◽  
Junn Yanagisawa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Growth Factor ◽  
Vitamin D Receptor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Receptor Function ◽  
Smad Proteins
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