scholarly journals 1α, 25-Dihydroxyvitamin D3 and the vitamin D receptor regulates ΔNp63α levels and keratinocyte proliferation

2015 ◽  
Vol 6 (6) ◽  
pp. e1781-e1781 ◽  
Author(s):  
N T Hill ◽  
J Zhang ◽  
M K Leonard ◽  
M Lee ◽  
H N Shamma ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
Keratinocyte Proliferation

Vitamin D receptor, a tumor suppressor in skin

2015 ◽  
Vol 93 (5) ◽  
pp. 349-354 ◽  
Author(s):  
Daniel D. Bikle
Keyword(s):  
Vitamin D ◽  
Tumor Suppressor ◽  
Vitamin D Receptor ◽  
Tumor Formation ◽  
Calcium Sensing Receptor ◽  
Keratinocyte Proliferation ◽  
Calcium Sensing ◽  
Damage Repair ◽  
Proliferation And Differentiation ◽  
Active Investigation

Vitamin D and calcium are well-established regulators of keratinocyte proliferation and differentiation. Therefore, it was not a great surprise that deletion of the vitamin D receptor (VDR) should predispose the skin to tumor formation, and that the combination of deleting both the VDR and calcium sensing receptor (CaSR) should be especially pro-oncogenic. In this review I have examined 4 mechanisms that appear to underlie the means by which VDR acts as a tumor suppressor in skin. First, DNA damage repair is curtailed in the absence of the VDR, allowing mutations in DNA to accumulate. Second and third involve the increased activation of the hedgehog and β-catenin pathways in the epidermis in the absence of the VDR, leading to poorly regulated proliferation with reduced differentiation. Finally, VDR deletion leads to a shift in the expression of long noncoding RNAs toward a more oncogenic profile. How these different mechanisms interact and their relative importance in the predisposition of the VDR null epidermis to tumor formation remain under active investigation.

Vitamin D receptor in IMR-90 human fibroblasts and antiproliferative effect of 1,25-dihydroxyvitamin D3

IUBMB Life ◽  
1997 ◽  
Vol 43 (6) ◽  
pp. 1173-1181 ◽  
Author(s):  
M. Stio ◽  
A. Celli ◽  
B. Lunghi ◽  
G. Raugei ◽  
A. Modesti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Human Fibroblasts ◽  
Antiproliferative Effect ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

Expression of vitamin D receptor, CYP27B1 and CYP24A1 hydroxylases and 1,25-dihydroxyvitamin D3 levels in stone formers

Urolithiasis ◽  
2019 ◽  
Vol 48 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Thalita Lima Melo ◽  
Priscila Ligeiro Gonçalves Esper ◽  
Lysien Ivania Zambrano ◽  
Milene Subtil Ormanji ◽  
Fernanda Guedes Rodrigues ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Stone Formers

scholarly journals Regulation of the murine renal vitamin D receptor by 1,25-dihydroxyvitamin D3 and calcium

2003 ◽  
Vol 100 (17) ◽  
pp. 9733-9737 ◽  
Author(s):  
K. D. Healy ◽  
J. B. Zella ◽  
J. M. Prahl ◽  
H. F. DeLuca
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3

scholarly journals SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation

2017 ◽  
Vol 172 ◽  
pp. 117-129 ◽  
Author(s):  
Marya S. Sabir ◽  
Zainab Khan ◽  
Chengcheng Hu ◽  
Michael A. Galligan ◽  
Christopher M. Dussik ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3
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