scholarly journals Genome-Wide Expression Analysis of Human In Vivo Irritated Epidermis: Differential Profiles Induced by Sodium Lauryl Sulfate and Nonanoic Acid

2010 ◽  
Vol 130 (9) ◽  
pp. 2201-2210 ◽  
Author(s):  
Anders Clemmensen ◽  
Klaus E. Andersen ◽  
Ole Clemmensen ◽  
Qihua Tan ◽  
Thomas K. Petersen ◽  
...  
Glia ◽  
2015 ◽  
Vol 63 (8) ◽  
pp. 1452-1468 ◽  
Author(s):  
Magdalena Götz ◽  
Swetlana Sirko ◽  
Johannes Beckers ◽  
Martin Irmler

2007 ◽  
Vol 2 (6) ◽  
pp. 1399-1413 ◽  
Author(s):  
Marnik Vuylsteke ◽  
Johan D Peleman ◽  
Michiel JT van Eijk

2005 ◽  
Vol 53 (5) ◽  
pp. 278-284 ◽  
Author(s):  
Nara Branco ◽  
Ivy Lee ◽  
Hongbo Zhai ◽  
Howard I. Maibach

2016 ◽  
Vol 15 (4) ◽  
Author(s):  
K.J. Lee ◽  
S.-J. Kwon ◽  
J.E. Hwang ◽  
S.M. Han ◽  
I. Jung ◽  
...  

2018 ◽  
Vol 85 (3) ◽  
pp. 375-387 ◽  
Author(s):  
Masoud Ahmadi-Afzadi ◽  
Mathilde Orsel ◽  
Sandra Pelletier ◽  
Maryline Bruneau ◽  
Estelle Proux-Wéra ◽  
...  

Author(s):  
KOMESMUNEEBORIRAK PHOJANA ◽  
WERAWATGANONE PORNPEN ◽  
MUANGSIRI WALAISIRI

Objective: At present, the nail preparation to cure onychomycosis, caused by non-dermatophyte molds, is not commercially available in Thailand. The physical and chemical stability of amphotericin B (AmB) extemporaneous preparations in the presence of 30% dimethyl sulfoxide (DMSO) and their in vitro nail permeation was evaluated. Methods: AmB extemporaneous preparations in the presence of 30% DMSO were prepared from a commercial sterile injection product, and cream or hydrophilic ointment. Physical stability was tested at 30°C for 2 months, or using 6 heating-cooling cycles. The chemical stability and in vitro nail permeation of AmB content were analyzed using high-performance liquid chromatography (HPLC). In vitro nail permeation was performed by applying 3.5 mg/mm2 of the tested formulation on nail clippings for 5 consecutive days. Results: The AmB cream and ointment extemporaneous preparations containing 30% DMSO, a permeation enhancer, were homogeneous and pale yellow to yellow cream or ointment. The AmB ointment was stable for up to 60 days. The ointment preparation allows in vitro penetration through nails up to 14.17 μg/cm2. The ointment preparation allows significantly better penetration through than the cream preparation due to the presence of DMSO, sodium lauryl sulfate (SLS), and water in the ointment preparation. Conclusion: The AmB extemporaneous ointment was successfully compounded from a commercial sterile injection product with a beyond-use date of 60 days. The ointment preparation is currently under further investigation for in vivo efficacy.


Sign in / Sign up

Export Citation Format

Share Document