scholarly journals Aryl Sulfatase in the Sebaceous Glands of Mouse Skin

1968 ◽  
Vol 51 (1) ◽  
pp. 41-50 ◽  
Author(s):  
G. Rowden
Keyword(s):  
Mouse Skin ◽  
Sebaceous Glands ◽  
Aryl Sulfatase

scholarly journals Transgenic mice carrying the guinea-pig α-lactalbumin gene transcribe milk protein genes in their sebaceous glands during lactation

1991 ◽  
Vol 275 (2) ◽  
pp. 459-467 ◽  
Author(s):  
A Maschio ◽  
P M Brickell ◽  
D Kioussis ◽  
A L Mellor ◽  
D Katz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transgenic Mice ◽  
Guinea Pig ◽  
Milk Protein ◽  
Mouse Skin ◽  
Sebaceous Glands ◽  
Milk Protein Gene ◽  
Milk Protein Genes ◽  
Milk Protein Gene Expression ◽  
Alpha Lactalbumin

We have generated transgenic mice carrying the entire guinea-pig alpha-lactalbumin gene. Lactating transgenic mice expressed high levels of correctly initiated and processed guinea-pig alpha-lactalbumin mRNA in the secretory epithelium of their mammary glands, and secreted guinea-pig alpha-lactalbumin in their milk. Transcripts were detectable after 7 days of pregnancy, indicating that the transgene was under correct hormonal control. Whereas no or negligible transcription was detectable in all other tissues tested, high levels of transcripts were found in the skin of lactating transgenic mice. Guinea-pig alpha-lactalbumin protein was undetectable in the skin, however. In situ hybridization analysis showed that expression was localized to the undifferentiated cells in the basal layer of the sebaceous glands. Further studies revealed high levels of endogenous beta-casein mRNA in normal lactating mouse skin, demonstrating that the transcription of milk protein genes in lactating mouse skin is a normal event, and is not peculiar to the transgene. This surprising finding highlights the developmental relationship of the mammary gland to other specialized structures of the skin, supports a role for epithelial-extracellular matrix interactions in the regulation of milk protein gene expression in vivo, and identifies the skin as a particularly accessible model system in which to study the regulation of milk protein gene expression. In addition, the guinea-pig alpha-lactalbumin gene will be a source of regulatory sequences with which to direct heterologous gene expression to the sebaceous glands of transgenic mice.

scholarly journals Destruction of Mouse Skin Sebaceous Glands by Actinomycin D*

1967 ◽  
Vol 49 (3) ◽  
pp. 309-313 ◽  
Author(s):  
Motoo Hozumi ◽  
Fred G. Bock
Keyword(s):  
Actinomycin D ◽  
Mouse Skin ◽  
Sebaceous Glands

scholarly journals Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands

2016 ◽  
Vol 25 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Yong Li ◽  
Stefan W. Stoll ◽  
Sahil Sekhon ◽  
Caroline Talsma ◽  
Maya I. Camhi ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Epidermal Hyperplasia ◽  
Sebaceous Glands ◽  
Transgenic Expression

p53 Mutations in Hairless SKH-hr1 Mouse Skin Tumors Induced by a Solar Simulator

1998 ◽  
Vol 67 (2) ◽  
pp. 227 ◽  
Author(s):  
Honnavara N. Ananthaswamy ◽  
Anny Fourtanier ◽  
Randall L. Evans ◽  
Sylvie Tison ◽  
Chantal Medaisko ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Skin Tumors ◽  
P53 Mutations ◽  
Solar Simulator
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