scholarly journals Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands

2016 ◽  
Vol 25 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Yong Li ◽  
Stefan W. Stoll ◽  
Sahil Sekhon ◽  
Caroline Talsma ◽  
Maya I. Camhi ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Epidermal Hyperplasia ◽  
Sebaceous Glands ◽  
Transgenic Expression

scholarly journals Transgenic mice carrying the guinea-pig α-lactalbumin gene transcribe milk protein genes in their sebaceous glands during lactation

1991 ◽  
Vol 275 (2) ◽  
pp. 459-467 ◽  
Author(s):  
A Maschio ◽  
P M Brickell ◽  
D Kioussis ◽  
A L Mellor ◽  
D Katz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transgenic Mice ◽  
Guinea Pig ◽  
Milk Protein ◽  
Mouse Skin ◽  
Sebaceous Glands ◽  
Milk Protein Gene ◽  
Milk Protein Genes ◽  
Milk Protein Gene Expression ◽  
Alpha Lactalbumin

We have generated transgenic mice carrying the entire guinea-pig alpha-lactalbumin gene. Lactating transgenic mice expressed high levels of correctly initiated and processed guinea-pig alpha-lactalbumin mRNA in the secretory epithelium of their mammary glands, and secreted guinea-pig alpha-lactalbumin in their milk. Transcripts were detectable after 7 days of pregnancy, indicating that the transgene was under correct hormonal control. Whereas no or negligible transcription was detectable in all other tissues tested, high levels of transcripts were found in the skin of lactating transgenic mice. Guinea-pig alpha-lactalbumin protein was undetectable in the skin, however. In situ hybridization analysis showed that expression was localized to the undifferentiated cells in the basal layer of the sebaceous glands. Further studies revealed high levels of endogenous beta-casein mRNA in normal lactating mouse skin, demonstrating that the transcription of milk protein genes in lactating mouse skin is a normal event, and is not peculiar to the transgene. This surprising finding highlights the developmental relationship of the mammary gland to other specialized structures of the skin, supports a role for epithelial-extracellular matrix interactions in the regulation of milk protein gene expression in vivo, and identifies the skin as a particularly accessible model system in which to study the regulation of milk protein gene expression. In addition, the guinea-pig alpha-lactalbumin gene will be a source of regulatory sequences with which to direct heterologous gene expression to the sebaceous glands of transgenic mice.

scholarly journals IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

2006 ◽  
Vol 203 (12) ◽  
pp. 2577-2587 ◽  
Author(s):  
Jason R. Chan ◽  
Wendy Blumenschein ◽  
Erin Murphy ◽  
Caroline Diveu ◽  
Maria Wiekowski ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Therapeutic Target ◽  
Tumor Necrosis ◽  
Mouse Skin ◽  
Epidermal Hyperplasia ◽  
Intradermal Administration ◽  
Independent Cascade ◽  
Dermal Infiltrate ◽  
Necrosis Factor ◽  
Novel Therapeutic

Aberrant cytokine expression has been proposed as an underlying cause of psoriasis, although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in human psoriasis and may be a master regulator cytokine. Direct intradermal administration of IL-23 in mouse skin, but not IL-12, initiates a tumor necrosis factor–dependent, but IL-17A–independent, cascade of events resulting in erythema, mixed dermal infiltrate, and epidermal hyperplasia associated with parakeratosis. IL-23 induced IL-19 and IL-24 expression in mouse skin, and both genes were also elevated in human psoriasis. IL-23–dependent epidermal hyperplasia was observed in IL-19−/− and IL-24−/− mice, but was inhibited in IL-20R2−/− mice. These data implicate IL-23 in the pathogenesis of psoriasis and support IL-20R2 as a novel therapeutic target.

Inhibitory action of cholesterol addition to tween 60 on the tumor promoting and epidermal hyperplasia causing effects in mouse skin

1959 ◽  
Vol 46 (9) ◽  
pp. 331-331 ◽  
Author(s):  
Kai Set�l� ◽  
Lauri Merenmies ◽  
Yrj� Aho ◽  
Leo Stjernvall ◽  
Onerva �yr�p��
Keyword(s):  
Inhibitory Action ◽  
Mouse Skin ◽  
Epidermal Hyperplasia ◽  
Tween 60

scholarly journals Transgenic Expression of Cyclin-Dependent Kinase 4 Results in Epidermal Hyperplasia, Hypertrophy, and Severe Dermal Fibrosis

2001 ◽  
Vol 159 (1) ◽  
pp. 369-379 ◽  
Author(s):  
Paula L. Miliani de Marval ◽  
Irma B. Gimenez-Conti ◽  
Margaret LaCava ◽  
Luis A. Martinez ◽  
Claudio J. Conti ◽  
...  
Keyword(s):  
Cyclin Dependent Kinase ◽  
Epidermal Hyperplasia ◽  
Transgenic Expression ◽  
Dermal Fibrosis
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