scholarly journals Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling

2009 ◽  
Vol 29 (9) ◽  
pp. 1547-1558 ◽  
Author(s):  
Ryo Ota ◽  
Chie Kurihara ◽  
Tsung-Ling Tsou ◽  
William L Young ◽  
Yerem Yeghiazarians ◽  
...  
Keyword(s):  
Blood Flow ◽  
Matrix Metalloproteinases ◽  
Carotid Artery ◽  
Knockout Mice ◽  
Common Carotid Artery ◽  
Vascular Remodeling ◽  
Luminal Diameter ◽  
Mmp Inhibitor ◽  
Doxycycline Treatment ◽  
Reduced Flow

Sustained hemodynamic stresses, especially high blood flow, result in flow-induced outward vascular remodeling. Our previous study showed that macrophage depletion reduced flow-induced outward remodeling of the rat common carotid artery, indicating that macrophages are critical in flow-induced outward vascular remodeling. Macrophage is known to release proteinases, including matrix metalloproteinases (MMPs). Degradation and loosening of extracellular matrix by MMPs may facilitate vascular remodeling. Therefore, we assessed the functions of MMPs in flow-induced outward vascular remodeling by using the flow-augmented common carotid artery model in mice. We validated that ligation of the left common carotid artery increased blood flow and luminal diameter of the right common carotid artery without significant change in blood pressure of mice. To assess the functions of MMPs in flow-induced outward vascular remodeling, we used doxycycline (broad-spectrum MMP inhibitor), SB-3CT (selective MMP inhibitor), MMP-9 knockout mice, and MMP-12 knockout mice. Although there was only a trend for doxycycline treatment to reduce flow-induced outward vascular remodeling, SB-3CT treatment significantly reduced flow-induced outward vascular remodeling. In addition, flow-induced outward vascular remodeling was significantly reduced in MMP-9 knockout mice, but not in MMP-12 knockout mice. These data revealed that MMPs, especially MMP-9, are critical in flow-induced outward vascular remodeling.

scholarly journals Roles of Macrophages in Flow-Induced Outward Vascular Remodeling

2008 ◽  
Vol 29 (3) ◽  
pp. 495-503 ◽  
Author(s):  
Yoshitsugu Nuki ◽  
Melissa M Matsumoto ◽  
Eric Tsang ◽  
William L Young ◽  
Nico van Rooijen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Vascular Remodeling ◽  
Time Course ◽  
Inflammatory Cells ◽  
Treated Group ◽  
Artery Ligation ◽  
Luminal Diameter ◽  
Hemodynamic Stresses

Sustained hemodynamic stresses, especially sustained high blood flow, result in flow-induced outward vascular remodeling. Mechanisms that link hemodynamic stresses to vascular remodeling are not well understood. Inflammatory cells, known for their release of proteinases, including matrix metalloproteinases (MMPs), are emerging as key mediators for various tissue remodeling. Using a flow-augmented common carotid artery model in rats, we tested whether macrophages play critical roles in adaptive outward vascular remodeling in response to an increase in blood flow. Left common carotid artery ligation caused a sustained increase in blood flow with a gradual increase in luminal diameter in the right common carotid artery. Macrophages infiltrated into the vascular wall that peaked 3 days after flow augmentation. The time course of MMP-9 expression coincided with infiltration of macrophages. Macrophage depletion by liposome-encapsulated dichloromethylene diphosphonate significantly reduced flow-induced outward vascular remodeling, as indicated by the smaller luminal diameter of flow-augmented right common carotid artery in the clodronate-treated group compared with the phosphate-buffered saline-treated group ( P<0.05). These data show critical roles of macrophages in flow-induced outward vascular remodeling. Inflammatory cell infiltration and their subsequent release of cytokines may be key processes for flow-induced outward vascular remodeling.

Basic study on estimation method of wall shear stress in common carotid artery using blood flow imaging

2020 ◽  
Vol 59 (SK) ◽  
pp. SKKE16 ◽  
Author(s):  
Ryo Nagaoka ◽  
Kazuma Ishikawa ◽  
Michiya Mozumi ◽  
Magnus Cinthio ◽  
Hideyuki Hasegawa
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
Estimation Method ◽  
Flow Imaging ◽  
Basic Study ◽  
Blood Flow Imaging ◽  
Wall Shear

scholarly journals LIGATION OF COMMON CAROTID ARTERY AND CEREBRAL BLOOD FLOW

1965 ◽  
Vol 68 (11) ◽  
pp. 1466-1471
Author(s):  
KENJIRO YANAGINO ◽  
NOBUO TAKASUGA ◽  
SANETOMI EGUCHI ◽  
TAKASHI FUKUSA
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Common Carotid Artery

scholarly journals The laryngeal mask airway reduces blood flow in the common carotid artery bulb

1998 ◽  
Vol 45 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Sally-Ann Colbert ◽  
Deirdre M. Ohanlon ◽  
Fidelma Flanagan ◽  
Rory Page ◽  
Denis C. Moriarty
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Laryngeal Mask Airway ◽  
Common Carotid Artery ◽  
Laryngeal Mask ◽  
The Common

ANALYSIS OF PREDICTORS OF EPILEPTIC SEIZURES

2020 ◽  
Vol 3 ◽  
pp. 112-121
Author(s):  
A.V. ZHIDKOV ◽  
A.A. MAKAROV ◽  
K.V. PODMASTERYEV ◽  
M.P. ZHILTSOV ◽  
D.E. CHEKMAREVA
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Statistical Data ◽  
Epileptic Seizures ◽  
Flow Dynamics ◽  
Velocity Change ◽  
Blood Flow Dynamics ◽  
The Common ◽  
The Brain

The statistical data on epilepsy, etiology and pathogenesis of the disease are given in the article. The main causes that affect the occurrence of epileptic seizures, and possible predictors that are sensitive to these causes (metabolic rate, blood flow velocity, change in electrical activity of the brain) are highlighted. The blood flow dynamics in the common carotid artery, which supplies the brain with oxygen and nutrients is proposed to be considered as one of the possible internal physiological parameters that are believed to be predictors of epileptic seizures.

The Effects of Propranolol and Esmolol on Blood Flow of Common Carotid Artery and Vital Signs in Rabbits

2000 ◽  
Vol 38 (3) ◽  
pp. 518
Author(s):  
Yong Hun Jung ◽  
Young Deok Sim ◽  
Je Hwan Oh ◽  
Su Won Oh ◽  
Young Cheol Woo ◽  
...  
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Vital Signs
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