scholarly journals Roles of Macrophages in Flow-Induced Outward Vascular Remodeling

2008 ◽  
Vol 29 (3) ◽  
pp. 495-503 ◽  
Author(s):  
Yoshitsugu Nuki ◽  
Melissa M Matsumoto ◽  
Eric Tsang ◽  
William L Young ◽  
Nico van Rooijen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Vascular Remodeling ◽  
Time Course ◽  
Inflammatory Cells ◽  
Treated Group ◽  
Artery Ligation ◽  
Luminal Diameter ◽  
Hemodynamic Stresses

Sustained hemodynamic stresses, especially sustained high blood flow, result in flow-induced outward vascular remodeling. Mechanisms that link hemodynamic stresses to vascular remodeling are not well understood. Inflammatory cells, known for their release of proteinases, including matrix metalloproteinases (MMPs), are emerging as key mediators for various tissue remodeling. Using a flow-augmented common carotid artery model in rats, we tested whether macrophages play critical roles in adaptive outward vascular remodeling in response to an increase in blood flow. Left common carotid artery ligation caused a sustained increase in blood flow with a gradual increase in luminal diameter in the right common carotid artery. Macrophages infiltrated into the vascular wall that peaked 3 days after flow augmentation. The time course of MMP-9 expression coincided with infiltration of macrophages. Macrophage depletion by liposome-encapsulated dichloromethylene diphosphonate significantly reduced flow-induced outward vascular remodeling, as indicated by the smaller luminal diameter of flow-augmented right common carotid artery in the clodronate-treated group compared with the phosphate-buffered saline-treated group ( P<0.05). These data show critical roles of macrophages in flow-induced outward vascular remodeling. Inflammatory cell infiltration and their subsequent release of cytokines may be key processes for flow-induced outward vascular remodeling.

scholarly journals Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling

2009 ◽  
Vol 29 (9) ◽  
pp. 1547-1558 ◽  
Author(s):  
Ryo Ota ◽  
Chie Kurihara ◽  
Tsung-Ling Tsou ◽  
William L Young ◽  
Yerem Yeghiazarians ◽  
...  
Keyword(s):  
Blood Flow ◽  
Matrix Metalloproteinases ◽  
Carotid Artery ◽  
Knockout Mice ◽  
Common Carotid Artery ◽  
Vascular Remodeling ◽  
Luminal Diameter ◽  
Mmp Inhibitor ◽  
Doxycycline Treatment ◽  
Reduced Flow

Sustained hemodynamic stresses, especially high blood flow, result in flow-induced outward vascular remodeling. Our previous study showed that macrophage depletion reduced flow-induced outward remodeling of the rat common carotid artery, indicating that macrophages are critical in flow-induced outward vascular remodeling. Macrophage is known to release proteinases, including matrix metalloproteinases (MMPs). Degradation and loosening of extracellular matrix by MMPs may facilitate vascular remodeling. Therefore, we assessed the functions of MMPs in flow-induced outward vascular remodeling by using the flow-augmented common carotid artery model in mice. We validated that ligation of the left common carotid artery increased blood flow and luminal diameter of the right common carotid artery without significant change in blood pressure of mice. To assess the functions of MMPs in flow-induced outward vascular remodeling, we used doxycycline (broad-spectrum MMP inhibitor), SB-3CT (selective MMP inhibitor), MMP-9 knockout mice, and MMP-12 knockout mice. Although there was only a trend for doxycycline treatment to reduce flow-induced outward vascular remodeling, SB-3CT treatment significantly reduced flow-induced outward vascular remodeling. In addition, flow-induced outward vascular remodeling was significantly reduced in MMP-9 knockout mice, but not in MMP-12 knockout mice. These data revealed that MMPs, especially MMP-9, are critical in flow-induced outward vascular remodeling.

Subclavian steal syndrome

1979 ◽  
Vol 51 (5) ◽  
pp. 628-640 ◽  
Author(s):  
George L. Bohmfalk ◽  
Jim L. Story ◽  
Willis E. Brown ◽  
Arthur E. Marlin
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Vertebral Artery ◽  
Upper Extremity ◽  
Common Carotid Artery ◽  
Subclavian Steal Syndrome ◽  
Artery Ligation ◽  
Subclavian Steal ◽  
The Brain ◽  
Steal Syndrome

✓ Three patients with central nervous system symptoms due to subclavian steal syndrome were treated with proximal vertebral to common carotid artery transposition. Neurological symptoms were relieved or improved in all three, with no decrease in blood pressure or pulse in the ipsilateral upper extremity. The colorful history of this syndrome is reviewed, and the various surgical approaches to its treatment are discussed. Although the literature suggests that the commonly used carotid to subclavian artery bypass graft and other similar extrathoracic procedures are generally safe and effective for relief of symptoms of the steal, there is also evidence that these bypasses may fail to restore antegrade flow in the vertebral artery, and, in fact, may steal from the carotid artery. Thus, the blood flow provided to the brain by these procedures may be hardly more than that provided by vertebral artery ligation, whereas the principal effect is to restore blood flow into the upper extremity. Vertebral artery ligation alone has been used in 20 patients, with neurological improvement in all cases and production of persistent intermittent brachial claudication in only one. These considerations and our patient experience suggest that a relatively simple operation, proximal vertebral to common carotid artery transposition, which emphasizes restoration of flow to the brain rather than to the upper extremity, may be preferable for most patients with neurological symptoms of subclavian steal syndrome.

Circle of Willis Blood Velocity and Flow Direction After Common Carotid Artery Ligation for Neonatal Extracorporeal Membrane Oxygenation

PEDIATRICS ◽  
1989 ◽  
Vol 83 (3) ◽  
pp. 343-347
Author(s):  
Tonse N. K. Raju ◽  
Shin Y. Kim ◽  
Janet L. Meller ◽  
Gopal Srinivasan ◽  
Vivek Ghai ◽  
...  
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Extracorporeal Membrane Oxygenation ◽  
Cerebral Artery ◽  
Common Carotid Artery ◽  
Circle Of Willis ◽  
Artery Ligation ◽  
Membrane Oxygenation ◽  
Carotid Artery Ligation ◽  
The Right

The velocity and direction of blood flow in the circle of Willis arteries were measured in three infants who underwent right common carotid artery ligation for extracorporeal membrane oxygenation treatment. Within 15 minutes of common carotid artery ligation, blood flow was detected in one infant's right middle cerebral artery; however, the velocity was reduced to 50% of the preextracorporeal membrane oxygenation level. The velocity remained 50% to 70% lower than normal during the 88 hours of extracorporeal membrane oxygenation therapy. In the other two infants, the velocity changes were less severe. By 2 to 10 weeks after weaning from extracorporeal membrane oxygenation, the velocities in the left cerebral arteries were increased to 116% to 217% of the corresponding right cerebral vessels. Following common carotid artery ligation, a retrograde direction of flow was noted in the first (A1) segment of the right anterior cerebral artery and in the right posterior communicating artery, whereas the direction of flow was normal in the corresponding vessels on the left. After common carotid artery ligation, the vertebrobasilar and the contralateral internal carotid systems appear to be the main sources of reperfusion of the right cerebral hemisphere via the circle of Willis. Furthermore, because of the known variants of the circle anatomy, a noninvasive pulsed Doppler method could be used to evaluate the flow patterns in the circle of Willis arteries, both before and after common carotid artery ligation for extracorporeal membrane oxygenation.

Basic study on estimation method of wall shear stress in common carotid artery using blood flow imaging

2020 ◽  
Vol 59 (SK) ◽  
pp. SKKE16 ◽  
Author(s):  
Ryo Nagaoka ◽  
Kazuma Ishikawa ◽  
Michiya Mozumi ◽  
Magnus Cinthio ◽  
Hideyuki Hasegawa
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
Estimation Method ◽  
Flow Imaging ◽  
Basic Study ◽  
Blood Flow Imaging ◽  
Wall Shear

Common carotid artery ligation at the proximal side before rupture in patients with ligation or occlusion of the external carotid artery at risk of carotid blowout syndrome

2019 ◽  
Vol 49 (9) ◽  
pp. 839-844
Author(s):  
Fumihiko Matsumoto ◽  
Satoko Matsumura ◽  
Taisuke Mori ◽  
Ayaka Mori ◽  
Go Omura ◽  
...  
Keyword(s):  
High Risk ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
External Carotid Artery ◽  
External Carotid ◽  
Artery Ligation ◽  
Bleeding Point ◽  
Carotid Blowout Syndrome ◽  
Proximal Side ◽  
Carotid Artery Ligation

CCA ligation at the proximal side of the bleeding point under local anesthesia and before rupture is a treatment option for patients at high risk of CBS.

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