scholarly journals Brain Blood Volume, Flow, and Oxygen Utilization Measured with 15O Radiotracers and Positron Emission Tomography: Revised Metabolic Computations

1987 ◽  
Vol 7 (4) ◽  
pp. 513-516 ◽  
Author(s):  
Tom O. Videen ◽  
Joel S. Perlmutter ◽  
Peter Herscovitch ◽  
Marcus E. Raichle
Keyword(s):  
Positron Emission Tomography ◽  
Blood Volume ◽  
Radioactive Decay ◽  
Volume Flow ◽  
Emission Tomography ◽  
Oxygen Utilization ◽  
Positron Emission ◽  
Measured Activity ◽  
Model Equations ◽  
Regional Blood Volume

We have revised our methods for calculating regional blood volume, flow, oxygen extraction, and oxygen utilization from positron emission tomography data obtained using 15O-labeled radiotracers. These revisions include radioactive decay explicitly within the model equations instead of requiring all measured activity to be corrected for decay prior to incorporation in the equations. The revised equations yield small but significant differences in the computed values.

Regional lung hematocrit in humans using positron emission tomography

1986 ◽  
Vol 60 (4) ◽  
pp. 1155-1163 ◽  
Author(s):  
L. H. Brudin ◽  
S. O. Valind ◽  
C. G. Rhodes ◽  
D. R. Turton ◽  
J. M. Hughes
Keyword(s):  
Positron Emission Tomography ◽  
Blood Volume ◽  
Venous Blood ◽  
Normal Subjects ◽  
Emission Tomography ◽  
Thoracic Wall ◽  
Positron Emission ◽  
Regional Lung ◽  
Volume Measurements ◽  
Regional Blood Volume

Regional lung hematocrit ratio (R) was measured in five normal subjects and five patients (2 with pneumonia, 2 with nephrotic syndrome with anemia, and 1 with pancreatitis) using positron emission tomography, a red cell marker 11CO, and a plasma marker [methyl-11C]albumin). The measurements were made in a transaxial thoracic section at midheart level with the subject in supine posture and with a spatial resolution of 1.7 cm. The normal regional hematocrit ratio (means +/- SE) calculated for the lung was 0.90 +/- 0.014, 0.94 +/- 0.023 for the thoracic wall, and 1.00 +/- 0.003 for the heart chambers. The regional lung hematocrit ratio in the patients ranged between 0.81 and 0.86. No correlation was found among the regional lung hematocrit ratio and regional blood volume, lung extravascular density, and the peripheral hematocrit (obtained from venous blood samples). To the extent that 70% of the pulmonary blood in the field of view is in larger vessels with normal hematocrit, the hematocrit in the capillary bed is approximately two-thirds that of the peripheral venous value. Blood volume measurements on the basis of single vascular tracers need to take account of these results.

scholarly journals Effects of Acetazolamide on Cerebral Blood Flow, Blood Volume, and Oxygen Metabolism: A Positron Emission Tomography Study with Healthy Volunteers

2001 ◽  
Vol 21 (12) ◽  
pp. 1472-1479 ◽  
Author(s):  
Hidehiko Okazawa ◽  
Hiroshi Yamauchi ◽  
Kanji Sugimoto ◽  
Hiroshi Toyoda ◽  
Yoshihiko Kishibe ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Metabolic Rate ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Capillary Blood ◽  
Emission Tomography ◽  
Positron Emission ◽  
Capillary Blood Volume

To evaluate changes in cerebral hemodynamics and metabolism induced by acetazolamide in healthy subjects, positron emission tomography studies for measurement of cerebral perfusion and oxygen consumption were performed. Sixteen healthy volunteers underwent positron emission tomography studies with15O-gas and water before and after intravenous administration of acetazolamide. Dynamic positron emission tomography data were acquired after bolus injection of H215O and bolus inhalation of15O2. Cerebral blood flow, metabolic rate of oxygen, and arterial-to-capillary blood volume images were calculated using the three-weighted integral method. The images of cerebral blood volume were calculated using the bolus inhalation technique of C15O. The scans for cerebral blood flow and volume and metabolic rate of oxygen after acetazolamide challenge were performed at 10, 20, and 30 minutes after drug injection. The parametric images obtained under the two conditions at baseline and after acetazolamide administration were compared. The global and regional values for cerebral blood flow and volume and arterial-to-capillary blood volume increased significantly after acetazolamide administration compared with the baseline condition, whereas no difference in metabolic rate of oxygen was observed. Acetazolamide-induced increases in both blood flow and volume in the normal brain occurred as a vasodilatory reaction of functioning vessels. The increase in arterial-to-capillary blood volume made the major contribution to the cerebral blood volume increase, indicating that the raise in cerebral blood flow during the acetazolamide challenge is closely related to arterial-to-capillary vasomotor responsiveness.

scholarly journals In vivo Measurement of Regional Cerebral Haematocrit Using Positron Emission Tomography

1984 ◽  
Vol 4 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Adriaan A. Lammertsma ◽  
David J. Brooks ◽  
Ronald P. Beaney ◽  
David R. Turton ◽  
Malcolm J. Kensett ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Mean Value ◽  
Emission Tomography ◽  
Regional Cerebral Blood ◽  
In Vivo Measurement ◽  
Positron Emission ◽  
Regional Cerebral Blood Volume

A method is described for measuring the regional cerebral-to-large vessel haematocrit ratio using inhalation of carbon-11-labelled carbon monoxide and the intravenous injection of carbon-11-labelled methyl-albumin in combination with positron emission tomography. The mean value in a series of nine subjects was 0.69. This is ∼20% lower than the value of 0.85 previously reported. It is concluded that previous measurements of regional cerebral blood volume using a haematocrit ratio of 0.85 will have underestimated the value of regional cerebral blood volume by 20%.

scholarly journals Validation of VASO cerebral blood volume measurement with positron emission tomography

2010 ◽  
Vol 65 (3) ◽  
pp. 744-749 ◽  
Author(s):  
Jinsoo Uh ◽  
Ai-Ling Lin ◽  
Kihak Lee ◽  
Peiying Liu ◽  
Peter Fox ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Volume Measurement ◽  
Emission Tomography ◽  
Positron Emission ◽  
Blood Volume Measurement

scholarly journals Measurement of blood flow and blood volume of the femoral head by positron emission tomography(PET) using C15O2 and C15O.

RADIOISOTOPES ◽  
1991 ◽  
Vol 40 (2) ◽  
pp. 75-78
Author(s):  
Masato YAMASHITA ◽  
Tadashi INABA ◽  
Shunichi KUBO ◽  
Mariko IDE ◽  
Yo USHIJIMA ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Femoral Head ◽  
Blood Volume ◽  
Emission Tomography ◽  
Positron Emission
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