scholarly journals Macrolactin S, a New Antibacterial Agent with Fab G-inhibitory Activity from Bacillus sp. AT28

2008 ◽  
Vol 61 (11) ◽  
pp. 687-691 ◽  
Author(s):  
Mi-Jin Sohn ◽  
Chang-Ji Zheng ◽  
Won-Gon Kim
Keyword(s):  
Inhibitory Activity ◽  
Antibacterial Agent ◽  
Bacillus Sp

Detection of the Active Compounds of the Hot Aqueous Extract of Cinnamomum cassia using FTIR Technology and Testing as Anti-bacterial and Antioxidant

2021 ◽  
Vol 8 (6) ◽  
pp. 95-101
Author(s):  
Afnan I. Abdulwahab
Keyword(s):  
Staphylococcus Aureus ◽  
Aqueous Extract ◽  
Inhibitory Activity ◽  
Bacillus Sp ◽  
Ftir Analysis ◽  
Bacterial Strains ◽  
Active Compounds ◽  
Cinnamon Bark ◽  
Cinnamomum Cassia ◽  
Inhibitory Ability

The results of the FTIR analysis of the hot aqueous extract of bark indicated that it contains many groups and active compounds, and the results of the bacterial tests conducted by digging and spreading method showed a high inhibitory activity of the hot aqueous extract of cinnamon against all pathogenic bacterial strains and at different concentrations. It was observed that the highest efficacy of the extract was against bacteria an inhibition diameter of 35 mm at concentration 800 mg/mL in Bacillus sp. while the bacterial strains were resistant to most of the antibiotics, in the study (Amoxicillin, Gentamycin, Ampicillin, Erythromycin, Tetracycline) except for gentamicin, which showed inhibition of bacteria Staphylococcus aureus with a diameter 19mm and Serratia sp. in diameter17mm. We conclude from the study that the cinnamon plant contains many active compounds and that the hot aqueous extract of Cinnamomum cassia (cinnamon) bark has a high inhibitory ability for different bacterial strains, which exceeded the inhibitory ability of antibiotics.

scholarly journals Synthesis of a New Type of Carbonic Anhydrases Inhibitors

2020 ◽  
Author(s):  
◽  
Aleksandrs Pustenko
Keyword(s):  
Inhibitory Activity ◽  
Antibacterial Agent ◽  
Selective Inhibitor ◽  
Carbonic Anhydrases ◽  
Scientific Publications ◽  
Doctoral Thesis ◽  
Ca Ix ◽  
New Type

The Doctoral Thesis has been prepared as a thematically united collection of scientific publications. It consists of a summary and five scientific publications. Publications have been written in English, their total volume is 39 pages. A new, selective class of CA IX and CA XII inhibitors – 3H-1,2-benzoxathiepine 2,2-dioxides, has been found. A series of 3H-1,2-benzoxathiepine 2,2-dioxide triazolyl, acylamino and aryl derivatives was synthesized. We discovered that furagin, a clinically used antibacterial agent, is a selective inhibitor of CA IX and CA XII. Developing this concept, we synthesized a series of imidazolidine-2,4-dione derivatives. Inhibitory activity on relevant human CA isoforms (I, II, IX, and XII) was determined for all products synthesized within the scope of the Doctoral Thesis.

scholarly journals Biocontrol activity of microoganisms on Botrytis isolates from vineyards

2020 ◽  
pp. 6-10
Author(s):  
Yara Suhan Juárez-Campusano ◽  
María del Socorro Chávaro-Ortiz ◽  
Lourdes Soto-Muñoz / ◽  
Juan Ramiro Pacheco-Aguilar
Keyword(s):  
Growth Inhibition ◽  
Botrytis Cinerea ◽  
Inhibitory Activity ◽  
Mycelial Growth ◽  
Fruit Rot ◽  
Bacillus Sp ◽  
Physiological Diversity ◽  
Grape Fruit ◽  
Biocontrol Activity

Botrytis cinerea causes postharvest fruit rot of an infinity of crops, the infective capacity is due to its physiological diversity that shown, even inside the same crop. For its control, the use of antagonistic microoganisms is emerging as a sustainable option. In the present work, 40 Botrytis isolates from three vineyards were characterized by their ability to infect grape fruit (Thomson Seedless), the results showed that all produced lesions diameters from 6.5 to 22.2 mm. Ten of these isolates that presented differences in terms of their virulence, were subject to in vitro antagonism test, using the yeasts Metschnikowia sp. NB9 and FLL17 (Kodamaea sp. FLL17 and the bacteria FR4B12 Bacillus sp. R4B12 from must and flower and fruit, respectively. The results showed that, on average, FRB412 had the highest inhibitory activity on the growth of Botrytis strains, exhibiting mycelial growth inhibition percentages from 51 to 81 %, followed by FLL17 (21 to 53 %) and NB9 (15 to 51 %). In conclusion, the three study strains have different ranges of biocontrol on Botrytis, whose application could reduce gray rot in grapes.

scholarly journals PRODUCTION OF ANTIBACTERIAL AGENT FROM FUNGI ISOLATED FROM PHARMACEUTICAL SOIL SAMPLE BY FERMENTATION UNDER OPTIMIZED CONDITIONS

2017 ◽  
Vol 10 (7) ◽  
pp. 110
Author(s):  
Anupama Bhardwaj ◽  
Sonia Chaman ◽  
Sangeeta Verma
Keyword(s):  
Antibacterial Activity ◽  
Soil Sample ◽  
Antibacterial Agent ◽  
Antibacterial Agents ◽  
Bacillus Sp ◽  
Disc Diffusion ◽  
Bacterial Isolates ◽  
Zone Of Inhibition ◽  
Fungal Isolates ◽  
Optimized Conditions

Objective: This study aimed to isolate fungi having antibacterial activity from pharmaceutical site soil sample and production of antibacterial agents by solid and submerged state fermentation under optimized conditions. Antibacterial activity of laboratory isolated and produced antibacterial agent was compared with other commercialized antibiotics to check the efficiency of laboratory produced antibacterial agent. Methods: For isolation and characterization of fungal isolates American Public Health Association standard was followed. Antibacterial activity was determined using disc diffusion and agar disc diffusion method. Results: On the basis of morphological and microscopic characteristics six fungal isolates belongs to four different genus species, i.e., Aspergillus sp. (F1, F2, F3), Penicillium sp. (F4), Rhizopus sp. (F5), and Fusarium sp. (F6), and they were tested against six bacterial isolates, i.e., Streptococcus sp. (B1), Bacillus sp. (B2), Staphylococcus sp. (B3), Bacillus sp. (B4), Bacillus sp. (B5), and Enterococcus sp. (B6). Except B4 all bacterial isolates growth were inhibited by fungal isolates. Under optimized conditions maximum zone of inhibition, i.e., 78 mm against B1 and B5 shown by F1 and F6 at 2% and 1% glucose concentration, respectively, at 10 pH. When comparison was made between commercialized antibiotics and lab produced antibacterial agents, it was observed lab produced antibacterial agent was more efficient in terms of zone of inhibition. Conclusion: Lab isolated and produced antibacterial agents were more efficient than commercialized antibiotics. This study demonstrated that lab isolated antibacterial agents isolated from six fungal isolates seems to be a stable and potent antibacterial and can be used as alternative to expensive commercialized antibiotics. 

scholarly journals Diversity among Pseudomonas syringae strains originating from fruit trees in Serbia

2009 ◽  
Vol 61 (4) ◽  
pp. 863-870 ◽  
Author(s):  
Zarko Ivanovic ◽  
Svetlana Zivkovic ◽  
Mira Starovic ◽  
Dragana Josic ◽  
S. Stankovic ◽  
...  
Keyword(s):  
Pseudomonas Syringae ◽  
Inhibitory Activity ◽  
Ornamental Plants ◽  
Sour Cherry ◽  
Fruit Trees ◽  
Bacillus Sp ◽  
Classification Methods ◽  
Field Crops ◽  
Pcr Method

Pseudomonas syringae is a widespread and economically important plant pathogen, one found on a number of hosts, including fruit trees, field crops, vegetables, and ornamental plants. This bacterium has been experimentally identified as a parasite of pear, apple, apricot, peach, cherry, sour cherry, plum, and raspberry. The present study was designed to establish differences between strains isolated from fruit trees in Serbia. The pathogenic and biochemical characteristics of isolates were studied. The BOX-PCR method was used to generate genomic fingerprints of Pseudomonas syringae isolates and to identify strains that were previously not distinguishable by other classification methods. Different Bacillus sp. strains were tested for in vitro inhibitory activity against Pseudononas syringae isolates. Bacillus sp. strains show inhibitory activity only against P. syringae isolates that originated from peach. The obtained results demonstrate that the population of the bacterium Pseudomonas syringae from the fruit trees in Serbia is very diverse.

scholarly journals Exploring Mediterranean and Arctic Environments as a Novel Source of Bacteria Producing Antibacterial Compounds to be Applied in Aquaculture

2020 ◽  
Vol 10 (11) ◽  
pp. 4006
Author(s):  
Carmen Rizzo ◽  
Concetta Gugliandolo ◽  
Angelina Lo Giudice
Keyword(s):  
Inhibitory Activity ◽  
Positive Response ◽  
Bacillus Sp ◽  
Bacterial Isolates ◽  
Antibacterial Compounds ◽  
Sediment Samples ◽  
Crude Extracts ◽  
Mediterranean Lake ◽  
Screening Procedures ◽  
Straits Of Messina

The need to discover new natural compounds has become urgent as a possible alternative solution to contrast the spread of antibiotic resistance, also in the aquaculture field. Bacterium–bacterium inhibitory activity against bacterial pathogens relevant in aquaculture was evaluated on agar plates for bacteria isolated from cold Arctic (Kongsfjorden, Svalbard Islands; i.e., seawater and sediment samples) and temperate Mediterranean (Lake Faro in Messina and the Straits of Messina, Italy; i.e., brackish water and benthic filter-feeding organisms) environments. Cell-free supernatants (both pure and concentrated 10-fold) were further assayed and, in the case of a positive response, crude extracts were obtained and tested. After the pre-screening procedures, about 30% of the bacterial isolates inhibited the growth of at least one pathogen used as a target. The 10-fold concentrated supernatants of two Arctic Salinibacterium spp. strains and the Mediterranean Bacillus sp. PS62 (associated with the pennatulacean Pteroeides spinosum Ellis, 1764) resulted in being active against P. damselae subsp. piscicida. The crude extracts obtained from Bacillus sp. PS62 also showed inhibitory activity against the same pathogen. Our findings suggest that tested bacteria could represent a novel source of compounds to be applied to overcome pathogenesis in the aquaculture field.

Inhibitory effects of bioaccessible anthocyanins and procyanidins from apple, red grape, cinnamon on α-amylase, α-glucosidase and lipase

2020 ◽  
pp. 1-9
Author(s):  
Pınar Ercan ◽  
Sedef Nehir El
Keyword(s):  
Inhibitory Activity ◽  
Digestive Enzymes ◽  
Positive Control ◽  
Anthocyanin Content ◽  
Inhibitory Effects ◽  
Total Anthocyanin ◽  
Total Anthocyanin Content ◽  
Before And After ◽  
Red Grape

Abstract. The goals of this study were to determine and evaluate the bioaccessibility of total anthocyanin and procyanidin in apple (Amasya, Malus communis), red grape (Papazkarası, Vitis vinifera) and cinnamon (Cassia, Cinnamomum) using an in vitro static digestion system based on human gastrointestinal physiologically relevant conditions. Also, in vitro inhibitory effects of these foods on lipid (lipase) and carbohydrate digestive enzymes (α-amylase and α-glucosidase) were performed with before and after digested samples using acarbose and methylumbelliferyl oleate (4MUO) as the positive control. While the highest total anthocyanin content was found in red grape (164 ± 2.51 mg/100 g), the highest procyanidin content was found in cinnamon (6432 ± 177.31 mg/100 g) (p < 0.05). The anthocyanin bioaccessibilities were found as 10.2 ± 1%, 8.23 ± 0.64%, and 8.73 ± 0.70% in apple, red grape, and cinnamon, respectively. The procyanidin bioaccessibilities of apple, red grape, and cinnamon were found as 17.57 ± 0.71%, 14.08 ± 0.74% and 18.75 ± 1.49%, respectively. The analyzed apple, red grape and cinnamon showed the inhibitory activity against α-glucosidase (IC50 544 ± 21.94, 445 ± 15.67, 1592 ± 17.58 μg/mL, respectively), α-amylase (IC50 38.4 ± 7.26, 56.1 ± 3.60, 3.54 ± 0.86 μg/mL, respectively), and lipase (IC50 52.7 ± 2.05, 581 ± 54.14, 49.6 ± 2.72 μg/mL), respectively. According to our results apple, red grape and cinnamon have potential to inhibit of lipase, α-amylase and α-glucosidase digestive enzymes.

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