An indoline-derived compound that markedly reduces mouse body weight

2012 ◽  
Vol 37 (5) ◽  
pp. 685-692
Author(s):  
M Tercel ◽  
R N Marnane ◽  
M A Tatnell ◽  
R J Stevenson ◽  
A Halim ◽  
...  
Keyword(s):  
Body Weight ◽  
Mouse Body Weight

Biotelemetry transmitter implantation in rodents: impact on growth and circadian rhythms

2004 ◽  
Vol 286 (5) ◽  
pp. R967-R974 ◽  
Author(s):  
Lisa R. Leon ◽  
Larry D. Walker ◽  
David A. DuBose ◽  
Lou A. Stephenson
Keyword(s):  
Body Weight ◽  
Core Body Temperature ◽  
Circadian Rhythmicity ◽  
Size Ratio ◽  
The Other ◽  
Experimental Paradigm ◽  
Surgical Implantation ◽  
Core Body ◽  
The Impact ◽  
Mouse Body Weight

The implantation of a biotelemetry transmitter for core body temperature (Tc) and motor activity (MA) measurements is hypothesized to have effects on growth and circadian rhythmicity depending on animal body-to-transmitter (B:T) size ratio. This study examined the impact of transmitter implantation (TM) on body weight, food intake (FI), water intake (WI), and circadian Tc and MA rhythms in mice (23.8 ± 0.04 g) and rats (311.5 ± 5.1 g) receiving no treatment (NT), anesthesia, laparotomy (LAP), and TM. The B:T size ratio was 6:1 and 84:1 for mice and rats, respectively. In mice, body weight required 14 days to recover to presurgical levels and never attained the level of the other groups. FI recovered in 3 days, whereas WI never reached presurgical levels. Rat body weight did not decrease below presurgical levels. FI and WI recovered to presurgical levels in rats by day 2 postsurgery. Anesthesia decreased mouse body weight for 1 wk, but was without effect in rats. LAP significantly decreased body weight for 5 days in mice and 1 day in rats, showing a significant effect of the surgical procedure in the absence of TM in both species. Circadian Tc and MA rhythms were evident within the first week in both species, indicating dissociation between circadian rhythmicity and recovery of growth variables. Cosinor analysis showed a TM effect on Tc min, Tc max, mesor, amplitude, and period of mice, whereas only the amplitude of the rhythm was affected in rats. These data indicate that a large B:T size ratio is associated with minimization of the adverse effects of surgical implantation. We recommend that B:T size ratio, recovery of presurgical body weight, and display of a robust circadian Tc and MA rhythm be established before collection of biotelemetry data collection under an experimental paradigm.

Increased Levels of Active Pertussis Toxin May Aid a Pertussis Vaccine to Pass the Mouse Body Weight Gain Test

Biologicals ◽  
1994 ◽  
Vol 22 (3) ◽  
pp. 243-248 ◽  
Author(s):  
Yoshinobu Horiuchi ◽  
Motohide Takahashi ◽  
Sakiyo Asada ◽  
Setsuji Ishida
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Pertussis Vaccine ◽  
Pertussis Toxin ◽  
Body Weight Gain ◽  
Mouse Body Weight

scholarly journals Low-dose paroxetine exposure causes lifetime declines in male mouse body weight, reproduction and competitive ability as measured by the novel organismal performance assay

2015 ◽  
Vol 47 ◽  
pp. 46-53 ◽  
Author(s):  
Shannon M. Gaukler ◽  
James S. Ruff ◽  
Tessa Galland ◽  
Kirstie A. Kandaris ◽  
Tristan K. Underwood ◽  
...  
Keyword(s):  
Body Weight ◽  
Male Mouse ◽  
Competitive Ability ◽  
Low Dose ◽  
The Novel ◽  
Mouse Body Weight

scholarly journals Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining

2016 ◽  
Vol 12 (6) ◽  
pp. 701-709 ◽  
Author(s):  
Yan Liu ◽  
Tong-Ruei R Li ◽  
Cong Xu ◽  
Tian Xu
Keyword(s):  
Body Weight ◽  
Gut Motility ◽  
Mouse Body Weight

scholarly journals ACUTE SKIN TOXICITY CHARACTERISTICS OF THE DRUG BASED ON MOXIDECTIN

2020 ◽  
pp. 39-45
Author(s):  
Belykh
Keyword(s):  
Body Weight ◽  
Single Channel ◽  
Skin Toxicity ◽  
Male Rats ◽  
Laboratory Animals ◽  
Control Group ◽  
Acute Skin Toxicity ◽  
Significant Difference ◽  
Experimental Group ◽  
Mouse Body Weight

The acute skin toxicity characteristics of the drug for veterinary use “Inspector Mini” were studied at mice and rats. The active ingredient of the drug is moxidectin which belongs to the group of macrocyclic lactones of the milbemycin class. The studies were carried out in the vivarium of VNIIP – FSC VIEV (Moscow, Russia) on 2 experimental and 1 control groups of white outbred male mice of 19–21 g, 10 animals in each group and male rats of 200–230 g, 6 individuals in each. The mass of animals was indicated during application of the drug. The drug was used once without dilution in the form of the provided solution with single-channel mechanical dispensers with a dosing volume of 10–100 μl for mice and 100–1000 μl for rats. The animals in the experimental group 1 were treated at a dose of 10 400 mg/kg (100 μl per 10 g of mouse body weight or 1000 μl per 100 g of rat body weight), animals in the experimental group 2 – at a dose of 5 200 mg/kg (50 μl per 10 g of mouse body weight or 500 μl per 100 g of rat body weight). The animals in control group were not treat with the drug. As a result of the study, it was found that the LD50 of the drug “Inspector Mini” applied to the skin of mice and rats was more than 10 400 mg/kg per animal weight. During clinical examination of laboratory animals from the experimental groups, no signs of intoxication were observed. During the experiment, there was no significant difference (p ≥ 0.05) in the animals weight from the experimental groups within all periods of weighing compared with the control group of analogues.

The Morphology of Vacuolated Cells in the Liver Following Administration of Vitamin A.

1973 ◽  
Vol 31 ◽  
pp. 408-409
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Electron Microscopy ◽  
Body Weight ◽  
Vitamin A ◽  
Light And Electron Microscopy ◽  
Liver Cells ◽  
Prominent Feature ◽  
Vascular Space ◽  
Vacuolated Cell ◽  
Vacuolated Cells ◽  
Vacuolated Cytoplasm

Vacuolated cells in the liver of young rats were studied by light and electron microscopy following the administration of vitamin A (200 units per gram of body weight). Their characteristics were compared with similar cells found in untreated animals.In rats given vitamin A, cells with vacuolated cytoplasm were a prominent feature. These cells were found mostly in a perisinusoidal location, although some appeared to be in between liver cells (Fig. 1). Electron microscopy confirmed their location in Disse's space adjacent to the sinusoid and in recesses between liver cells. Some appeared to be bordering the lumen of the sinusoid, but careful observation usually revealed a tenuous endothelial process separating the vacuolated cell from the vascular space. In appropriate sections, fenestrations in the thin endothelial processes were noted (Fig. 2, arrow).

Nucleolar Segregation and Chronic Methanol Intoxication

1969 ◽  
Vol 27 ◽  
pp. 360-361
Author(s):  
Julio H. Garcia ◽  
Janice P. Van Zandt
Keyword(s):  
Body Weight ◽  
Methyl Alcohol ◽  
Rhesus Monkeys ◽  
Repeated Administration ◽  
Serum Levels ◽  
Methanol Intoxication ◽  
Intragastric Tube ◽  
Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

Electron microscopic radioautographic studies on the incorporation of 3H proline in the glomerular basement membrane (GBM) in antistreptococcal-cell-membrane (SCM) injected mice

1984 ◽  
Vol 42 ◽  
pp. 188-189
Author(s):  
R.P. Nayyar ◽  
C.F. Lange ◽  
J. L. Borke
Keyword(s):  
Body Weight ◽  
Cell Membrane ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Mesangial Matrix ◽  
Electron Microscopic ◽  
Group A ◽  
Injection Protocol

Streptococcal cell membrane (SCM) antiserum injected mice show a significant thickening of glomerular basement membrane (GBM) and an increase in mesangial matrix within 4 to 24 hours of antiserum administration (1,2,3). This study was undertaken to evaluate the incorporation of 3H proline into glomerular cells and GBM under normal and anti-SCM induced conditions. Mice were administered, intraperitoneally, 0.1 ml of normal or anti-SCM serum followed by a 10 µC/g body weight injection of 3H proline. Details of the preparation of anti-SCM (Group A type 12 streptococcal pyogenes) and other sera and injection protocol have been described elsewhere (2). After 15 minutes of isotope injection a chase of cold proline was given and animal sacrificed at 20 minutes, 1,2,4,8,24 and 48 hours. One of the removed kidneys was processed for immunofluorescence, light and electron microscopic radioautographic studies; second kidney was used for GBM isolation and aminoacid analysis.

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