scholarly journals Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

2011 ◽  
Vol 36 (11) ◽  
pp. 1442-1449 ◽  
Author(s):  
J M Moreno-Navarrete ◽  
F Ortega ◽  
M Serino ◽  
E Luche ◽  
A Waget ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Lipopolysaccharide Binding

scholarly journals Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents

2016 ◽  
Vol 59 (5) ◽  
pp. 231 ◽  
Author(s):  
Ki Eun Kim ◽  
Young Sun Cho ◽  
Kyung Suk Baek ◽  
Lan Li ◽  
Kwang-Hyun Baek ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Plasma Levels ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Lipopolysaccharide Binding

scholarly journals Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels

2020 ◽  
Vol 318 (4) ◽  
pp. G736-G747
Author(s):  
Cheng Jun Jin ◽  
Anja Baumann ◽  
Annette Brandt ◽  
Anna Janina Engstler ◽  
Anika Nier ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Damage ◽  
Binding Protein ◽  
Bacterial Endotoxin ◽  
Toll Like Receptor ◽  
Hepatic Inflammation ◽  
Lipopolysaccharide Binding Protein ◽  
Toll Like Receptor 4 ◽  
Liver Degeneration ◽  
Lipopolysaccharide Binding

Aging is a risk factor in the development of many diseases, including liver-related diseases. The two aims of the present study were 1) to determine how aging affects liver health in mice in the absence of any interventions and 2) if degenerations observed in relation to blood endotoxin levels are critical in aging-associated liver degeneration. Endotoxin levels and markers of liver damage, mitochondrial dysfunction, insulin resistance, and apoptosis as well as the Toll-like receptor 4 (Tlr-4) signaling cascade were studied in liver tissue and blood, respectively, of 3- and 24-mo-old male C57BL/6J mice. In a second set of experiments, 3- to 4-mo-old and 14-mo-old female lipopolysaccharide-binding protein (LBP)−/− mice and littermates fed standard chow, markers of liver damage, insulin resistance, and mitochondrial dysfunction were assessed. Plasma activity of aspartate aminotransferase and histological signs of hepatic inflammation and fibrosis were significantly higher in old C57BL/6J mice than in young animals. The number of neutrophils, CD8α-positive cells, and mRNA expression of markers of apoptosis were also significantly higher in livers of old C57BL/6J mice compared with young animals, being also associated with a significant induction of hepatic Tlr-4 and LBP expression as well as higher endotoxin levels in peripheral blood. Compared with age-matched littermates, LBP−/− mice display less signs of senescence in liver. Taken together, our data suggest that, despite being fed standard chow, old mice developed liver inflammation and beginning fibrosis and that bacterial endotoxin may play a critical role herein. NEW & NOTEWORTHY Old age in mice is associated with marked signs of liver degeneration, hepatic inflammation, and fibrosis. Aging-associated liver degeneration is associated with elevated bacterial endotoxin levels and an induction of lipopolysaccharide-binding protein (LBP) and Toll-like receptor 4-dependent signaling cascades in liver tissue. Furthermore, in old aged LBP−/− mice, markers of senescence seem to be lessened, supporting the hypothesis that bacterial endotoxin levels might be critical in aging-associated decline of liver.

scholarly journals Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 289
Author(s):  
Amelia Marti ◽  
Isabel Martínez ◽  
Ana Ojeda-Rodríguez ◽  
María Cristina Azcona-Sanjulian
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Lifestyle Intervention ◽  
Abdominal Obesity ◽  
Plasma Levels ◽  
Intervention Program ◽  
Binding Protein ◽  
Controlled Trial ◽  
Lipopolysaccharide Binding Protein ◽  
Lipopolysaccharide Binding

Background: Elevated circulating plasma levels of both lipopolysaccharide-binding protein (LBP) and chemerin are reported in patients with obesity, but few studies are available on lifestyle intervention programs. We investigated the association of both LBP and chemerin plasma levels with metabolic syndrome (MetS) outcomes in a lifestyle intervention in children and adolescents with abdominal obesity Methods: Twenty-nine patients enrolled in a randomized controlled trial were selected. The lifestyle intervention with a 2-month intensive phase and a subsequent 10-month follow-up consisted of a moderate calorie-restricted diet, recommendations to increase physical activity levels, and nutritional education. Results: Weight loss was accompanied by a significant reduction in MetS prevalence (−43%; p = 0.009). Chemerin (p = 0.029) and LBP (p = 0.033) plasma levels were significantly reduced at 2 months and 12 months, respectively. At the end of intervention, MetS components were associated with both LBP (p = 0.017) and chemerin (p < 0.001) plasma levels. Conclusions: We describe for the first time a reduction in both LBP and chemerin plasma levels and its association with MetS risk factors after a lifestyle intervention program in children and adolescents with abdominal obesity. Therefore, LBP and chemerin plasma levels could be used as biomarkers for the progression of cardiovascular risk in pediatric populations.

scholarly journals Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice

2021 ◽  
Vol 9 (5) ◽  
pp. 505
Author(s):  
Jingyi Yuan ◽  
Song Qin ◽  
Wenjun Li ◽  
Yubing Zhang ◽  
Yuting Wang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Triglyceride Level ◽  
Lactobacillus Reuteri ◽  
Binding Protein ◽  
Serum Triglyceride ◽  
Serum Triglyceride Level ◽  
Lipopolysaccharide Binding Protein ◽  
Lactobacillus Gasseri ◽  
Lactobacillus Animalis ◽  
Lipopolysaccharide Binding

Fucoidan is a kind of polysaccharide with antitumor and antioxidant properties, which is mainly isolated from brown algae. Although there are many reports about the prebiotic effects of polysaccharides on hosts, there are few reports about the effects of fucoidan on blood biochemical indexes, intestinal microbiome, and metabolic function on healthy hosts. We applied 16S rRNA gene amplicon sequencing and LC-MS/MS metabolomics to evaluate the changes in the gut microbiome and metabolite profiles of fucoidan treatment in mice over 10 weeks. Fucoidan treatment modulated lipid metabolism, including significantly decreasing serum triglyceride level in healthy mice. Fucoidan also significantly inhibited serum lipopolysaccharide-binding protein (LBP) concentration, a biomarker of endotoxemia. Correlation analysis further showed that Lactobacillus animalis populations that were enriched by fucoidan demonstrated significantly negative correlations with serum triglyceride level. The abundance of Lactobacillus gasseri and Lactobacillus reuteri, increased by fucoidan supplementation, demonstrated significantly negative correlation with lipopolysaccharide-binding protein levels. Lactobacillus gasseri also demonstrated significantly positive correlations with three tryptophan-related metabolites, including indoleacrylic acid, 3-indoleacrylic acid, and 5-hydroxytryptamine, which were all increased by fucoidan administration. Combined with the previous evidence, the results indicate that fucoidan exerts prebiotic effects, such as lipid metabolism suppression and metabolic endotoxemia suppression, by modulating the abundance of gut microbiota, such as Lactobacillus animalis, Lactobacillus gasseri, and Lactobacillus reuteri, as well as microbiota-dependent metabolites, such as tryptophan-related metabolites.

Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients

2001 ◽  
Vol 29 (3) ◽  
pp. 557-561 ◽  
Author(s):  
Jaroslav A. Hubacek ◽  
Frank Stüber ◽  
Dieter Fröhlich ◽  
Malte Book ◽  
Silke Wetegrove ◽  
...  
Keyword(s):  
Binding Protein ◽  
Gene Variants ◽  
Lipopolysaccharide Binding Protein ◽  
Lipopolysaccharide Binding

Lipopolysaccharide-Binding Protein Is an Early Biomarker of Cardiac Function After Radiation Therapy for Breast Cancer

2019 ◽  
Vol 104 (5) ◽  
pp. 1074-1083 ◽  
Author(s):  
Justyna Chalubinska-Fendler ◽  
Lukasz Graczyk ◽  
Grzegorz Piotrowski ◽  
Krystyna Wyka ◽  
Zuzanna Nowicka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cardiac Function ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Early Biomarker ◽  
Lipopolysaccharide Binding

The Kinetic Expression of Lipopolysaccharide-Binding Protein and CD14 Gene in Obstructive Jaundice

2014 ◽  
Vol 28 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Ching-Hua Tsai ◽  
Cheng-Hsi Yeh ◽  
Shyr-Ming Sheen-Chen ◽  
Chun-Ying Huang ◽  
Yueh-Wei Liu ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Kinetic Expression ◽  
Cd14 Gene ◽  
Lipopolysaccharide Binding

scholarly journals Serum Lipopolysaccharide-Binding Protein Concentrations in Trauma Victims

2006 ◽  
Vol 7 (3) ◽  
pp. 251-261 ◽  
Author(s):  
Steven C. Cunningham ◽  
Debra L. Malone ◽  
Grant V. Bochicchio ◽  
Thomas Genuit ◽  
Kaspar Keledjian ◽  
...  
Keyword(s):  
Binding Protein ◽  
Lipopolysaccharide Binding Protein ◽  
Trauma Victims ◽  
Lipopolysaccharide Binding
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