scholarly journals Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

2011 ◽  
Vol 36 (3) ◽  
pp. 369-378 ◽  
Author(s):  
L Di Renzo ◽  
M G Carbonelli ◽  
A Bianchi ◽  
L Iacopino ◽  
R Fiorito ◽  
...  
Keyword(s):  
Body Composition ◽  
Gene Polymorphism ◽  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Interleukin 6 ◽  
Adjustable Gastric Banding ◽  
Therapeutic Strategy ◽  
Promoter Gene ◽  
Composition Changes

scholarly journals Impact of the −174 G>C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Laura Di Renzo ◽  
Maria Grazia Carbonelli ◽  
Alessia Bianchi ◽  
Emidio Domino ◽  
Maria Rita Migliore ◽  
...  
Keyword(s):  
Body Composition ◽  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Adjustable Gastric Banding ◽  
Therapeutic Response ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Fluid Distribution ◽  
Obese Subjects ◽  
The Impact

Background. Recent data demonstrated that the−174 G>CIL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery.Objective. We investigated the impact of−174 G>CIL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB.Design and Outcome Measures. Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of−174 G>CIL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed.Results. At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactanceXc, andXc/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(−) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, andXc/Hwere highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), andR/height were obtained. Significant higher reductions in BMI andXc/Hwere observed in C(+) with respect to C(−) carriers.Conclusions. Genotyping of genetic variants, for example, the−174 G>Cpolymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.

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