scholarly journals Impact of the −174 G>C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Laura Di Renzo ◽  
Maria Grazia Carbonelli ◽  
Alessia Bianchi ◽  
Emidio Domino ◽  
Maria Rita Migliore ◽  
...  
Keyword(s):  
Body Composition ◽  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Adjustable Gastric Banding ◽  
Therapeutic Response ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Fluid Distribution ◽  
Obese Subjects ◽  
The Impact

Background. Recent data demonstrated that the−174 G>CIL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery.Objective. We investigated the impact of−174 G>CIL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB.Design and Outcome Measures. Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of−174 G>CIL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed.Results. At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactanceXc, andXc/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(−) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, andXc/Hwere highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), andR/height were obtained. Significant higher reductions in BMI andXc/Hwere observed in C(+) with respect to C(−) carriers.Conclusions. Genotyping of genetic variants, for example, the−174 G>Cpolymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.

Impact of Gastric Prolapse after Laparoscopic Adjustable Gastric Banding for Morbid Obesity

2014 ◽  
Vol 80 (11) ◽  
pp. 1164-1168
Author(s):  
John P. Davis ◽  
Damien J. LaPar ◽  
Bruce D. Schirmer ◽  
Peter T. Hallowell
Keyword(s):  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Adjustable Gastric Banding ◽  
Laparoscopic Gastric Banding ◽  
Morbidly Obese ◽  
Patient Demographics ◽  
Average Patient ◽  
Low Incidence ◽  
The Impact ◽  
Univariate Analyses

Gastric prolapse (GP) after laparoscopic adjustable gastric banding (LAGB) remains a complication that has the potential to result in significant morbidities. The purpose of this study was to evaluate the incidence of GP after LAGB and to determine its impact on patient outcomes among the morbidly obese. From 2005 to 2012, 379 consecutive morbidly obese patients underwent LAGB procedures at a single institution. Patients were placed into two groups based on the occurrence of gastric prolapse (GP vs no GP). Patient demographics and risk factors, operative features, and postoperative outcomes were analyzed by univariate analyses to assess the impact of GP. Average patient age was 47 ± 29 years and patients were commonly female (80%) with a median body mass index (BMI) of 44 kg/m2. Incidence of GP was 4.2 per cent (n = 16). LAGB median BMIs at 1 month and 1 year were 41 and 36 kg/m2. There was no difference in 1-year weight loss (BMI GP: 36 kg/m2 vs no GP: 36 kg/m2, P = 0.617). Laparoscopic gastric banding results in significant weight reduction and a low incidence of gastric prolapse. Gastric prolapse has no difference in 1-year postoperative median BMI when compared with patients who did not prolapse.

scholarly journals Laparoscopic Adjustable Gastric Banding—Should a Second Chance Be Given?

2020 ◽  
Vol 30 (8) ◽  
pp. 2913-2919
Author(s):  
Bianca M. Leca ◽  
Uzma Khan ◽  
Jenny Abraham ◽  
Louise Halder ◽  
Emma Shuttlewood ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Banding ◽  
Laparoscopic Adjustable Gastric Banding ◽  
Adjustable Gastric Banding ◽  
Significant Drop ◽  
Global Pandemic ◽  
Severely Obese ◽  
Treatment Of Obesity ◽  
Successful Weight Loss ◽  
The Impact

Abstract Background Obesity is a chronic relapsing-remitting disease and a global pandemic, being associated with multiple comorbidities. Laparoscopic adjustable gastric banding (LAGB) is one of the safest surgical procedures used for the treatment of obesity, and even though its popularity has been decreasing over time, it still remains an option for a certain group of patients, producing considerable weight loss and improvement in obesity-associated comorbidities. Methods The aim of this study was to evaluate the impact of weight loss following LAGB on obesity-associated comorbidities, and to identify factors that could predict better response to surgery, and patient sub-groups exhibiting greatest benefit. A total of 99 severely obese patients (81.2% women, mean age 44.19 ± 10.94 years, mean body mass index (BMI) 51.84 ± 8.77 kg/m2) underwent LAGB in a single institution. Results obtained 1, 2, and 5 years postoperatively were compared with the pre-operative values using SPPS software version 20. Results A significant drop in BMI was recorded throughout the follow-up period, as well as in A1c and triglycerides, with greatest improvement seen 2 years after surgery (51.8 ± 8.7 kg/m2 vs 42.3 ± 9.2 kg/m2, p < 0.05, 55.5 ± 19.1 mmol/mol vs 45.8 ± 13.7 mmol/mol, p < 0.05, and 2.2 ± 1.7 mmol/l vs 1.5 ± 0.6 mmol/l). Better outcomes were seen in younger patients, with lower duration of diabetes before surgery, and lower pre-operative systolic blood pressure. Conclusions Younger age, lower degree of obesity, and lower severity of comorbidities at the time of surgery can be important predictors of successful weight loss, making this group of patients the ideal candidates for LAGB.

Estimation of human body composition by electrical impedance methods: a comparative study

1985 ◽  
Vol 58 (5) ◽  
pp. 1565-1571 ◽  
Author(s):  
K. R. Segal ◽  
B. Gutin ◽  
E. Presta ◽  
J. Wang ◽  
T. B. Van Itallie
Keyword(s):  
Body Composition ◽  
Human Body ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Prediction Equations ◽  
Uniform Current ◽  
Obese Subjects ◽  
Total Body ◽  
The Relationship ◽  
Human Body Composition

This study 1) further validated the relationship between total body electrical conductivity (TOBEC) and densitometrically determined lean body mass (LBMd) and 2) compared with existing body composition techniques (densitometry, total body water, total body potassium, and anthropometry) two new electrical methods for the estimation of LBM: TOBEC, a uniform current induction method, and bioelectrical impedance analysis (BIA), a localized current injection method. In a sample of 75 male and female subjects ranging from 4.9 to 54.9% body fat the correlation between LBMd and LBM predicted from TOBEC by use of a previously developed regression equation was extremely strong (r = 0.962), thus confirming the validity of the TOBEC method. LBM predicted from BIA by use of prediction equations provided with the instrument also correlated with LBMd (r = 0.912) but overestimated LBM compared with LBMd in obese subjects. However, no such systematic error was apparent when new prediction equations derived from this heterogeneous sample of subjects were applied. Thus the TOBEC and BIA methods, which are based on the differing electrical properties of lean tissue and fat and which are convenient, rapid, and safe, correlate well with more cumbersome human body composition techniques.

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