scholarly journals The role of G protein‐coupled receptors in mast cell activation by antimicrobial peptides: is there a connection?

2010 ◽  
Vol 88 (6) ◽  
pp. 632-640 ◽  
Author(s):  
Priyanka Pundir ◽  
Marianna Kulka
Keyword(s):  
Mast Cell ◽  
Antimicrobial Peptides ◽  
G Protein ◽  
Cell Activation ◽  
G Protein Coupled Receptors ◽  
Mast Cell Activation ◽  
G Protein Coupled

scholarly journals Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2)

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1033
Author(s):  
Mukesh Kumar ◽  
Karthi Duraisamy ◽  
Billy Kwok Chong CHOW
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Allergic Reaction ◽  
G Protein ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Allergic Reactions ◽  
Ige Mediated ◽  
G Protein Coupled

Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell response, allergic response, and vascular homeostasis. Immunoglobulin E receptor (FcεRI)-mediated mast cell activation is a well-studied and recognized mechanism of allergy and hypersensitivity reactions. However, non-IgE-mediated mast cell activation is less explored and is not well recognized. After decades of uncertainty, MRGPRX2 was discovered as the receptor responsible for non-IgE-mediated mast cells activation. The puzzle of non-IgE-mediated pseudo-allergic reaction is unlocked by MRGPRX2, evidenced by a plethora of reported endogenous and exogenous MRGPRX2 agonists. MRGPRX2 is exclusively expressed on mast cells and exhibits varying affinity for many molecules such as antimicrobial host defense peptides, neuropeptides, and even US Food and Drug Administration-approved drugs. The discovery of MRGPRX2 has changed our understanding of mast cell biology and filled the missing link of the underlying mechanism of drug-induced MC degranulation and pseudo-allergic reactions. These non-canonical characteristics render MRGPRX2 an intriguing player in allergic diseases. In the present article, we reviewed the emerging role of MRGPRX2 as a non-IgE-mediated mechanism of mast cell activation in pseudo-allergic reactions. We have presented an overview of mast cells, their receptors, structural insight into MRGPRX2, MRGPRX2 agonists and antagonists, the crucial role of MRGPRX2 in pseudo-allergic reactions, current challenges, and the future research direction.

LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2

2017 ◽  
Vol 49 ◽  
pp. 6-12 ◽  
Author(s):  
Yangyang Yu ◽  
Yuanyuan Zhang ◽  
Yarui Zhang ◽  
Yihong Lai ◽  
Wenwen Chen ◽  
...  
Keyword(s):  
Mast Cell ◽  
G Protein ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals The Role of G Protein-Coupled Receptors in the Right Ventricle in Pulmonary Hypertension

2018 ◽  
Vol 5 ◽  
Author(s):  
Gayathri Viswanathan ◽  
Argen Mamazhakypov ◽  
Ralph T. Schermuly ◽  
Sudarshan Rajagopal
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricle ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
The Right ◽  
G Protein Coupled

scholarly journals The role of membrane curvature elastic stress for function of rhodopsin-like G protein-coupled receptors

Biochimie ◽  
2014 ◽  
Vol 107 ◽  
pp. 28-32 ◽  
Author(s):  
Olivier Soubias ◽  
Walter E. Teague ◽  
Kirk G. Hines ◽  
Klaus Gawrisch
Keyword(s):  
G Protein ◽  
Elastic Stress ◽  
Membrane Curvature ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

scholarly journals Atypical Chemokine Receptors in Cardiovascular Disease

2019 ◽  
Vol 119 (04) ◽  
pp. 534-541 ◽  
Author(s):  
Selin Gencer ◽  
Emiel van der Vorst ◽  
Maria Aslani ◽  
Christian Weber ◽  
Yvonne Döring ◽  
...  
Keyword(s):  
G Protein ◽  
Chemokine Receptors ◽  
Cellular Response ◽  
Current Knowledge ◽  
G Protein Coupled Receptors ◽  
Signalling Pathways ◽  
Atherosclerosis Development ◽  
G Protein Coupled ◽  
Precise Role

AbstractInflammation has been well recognized as one of the main drivers of atherosclerosis development and therefore cardiovascular diseases (CVDs). It has been shown that several chemokines, small 8 to 12 kDa cytokines with chemotactic properties, play a crucial role in the pathophysiology of atherosclerosis. Chemokines classically mediate their effects by binding to G-protein-coupled receptors called chemokine receptors. In addition, chemokines can also bind to atypical chemokine receptors (ACKRs). ACKRs fail to induce G-protein-dependent signalling pathways and thus subsequent cellular response, but instead are able to internalize, scavenge or transport chemokines. In this review, we will give an overview of the current knowledge about the involvement of ACKR1–4 in CVDs and especially in atherosclerosis development. In the recent years, several studies have highlighted the importance of ACKRs in CVDs, although there are still several controversies and unexplored aspects that have to be further elucidated. A better understanding of the precise role of these atypical receptors may pave the way towards novel and improved therapeutic strategies.

The Role of MC1R in Speciation & Phylogeny

2013 ◽  
Vol 75 (9) ◽  
pp. 670-676 ◽  
Author(s):  
Susan Offner
Keyword(s):  
G Protein ◽  
Point Mutation ◽  
Solomon Island ◽  
G Protein Coupled Receptors ◽  
Ancestral Population ◽  
Mc1r Gene ◽  
The Many ◽  
Evolutionary Consequences ◽  
G Protein Coupled

A point mutation in the MC1R gene, a G-protein-coupled receptor, has been found that could have led to the formation of two subspecies of Solomon Island flycatcher from a single ancestral population. I discuss the many roles that G-protein-coupled receptors play in vertebrate physiology and how one particular point mutation can have enormous evolutionary consequences.

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