Mivacurium induce mast cell activation and pseudo-allergic reactions via MAS-related G protein coupled receptor-X2

2018 ◽  
Vol 332 ◽  
pp. 121-128 ◽  
Author(s):  
Delu Che ◽  
Jue Wang ◽  
Yuanyuan Ding ◽  
Rui Liu ◽  
Jiao Cao ◽  
...  
Keyword(s):  
Mast Cell ◽  
G Protein ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Allergic Reactions ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2

2017 ◽  
Vol 49 ◽  
pp. 6-12 ◽  
Author(s):  
Yangyang Yu ◽  
Yuanyuan Zhang ◽  
Yarui Zhang ◽  
Yihong Lai ◽  
Wenwen Chen ◽  
...  
Keyword(s):  
Mast Cell ◽  
G Protein ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Human Mast Cell ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2)

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1033
Author(s):  
Mukesh Kumar ◽  
Karthi Duraisamy ◽  
Billy Kwok Chong CHOW
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Allergic Reaction ◽  
G Protein ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Allergic Reactions ◽  
Ige Mediated ◽  
G Protein Coupled

Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell response, allergic response, and vascular homeostasis. Immunoglobulin E receptor (FcεRI)-mediated mast cell activation is a well-studied and recognized mechanism of allergy and hypersensitivity reactions. However, non-IgE-mediated mast cell activation is less explored and is not well recognized. After decades of uncertainty, MRGPRX2 was discovered as the receptor responsible for non-IgE-mediated mast cells activation. The puzzle of non-IgE-mediated pseudo-allergic reaction is unlocked by MRGPRX2, evidenced by a plethora of reported endogenous and exogenous MRGPRX2 agonists. MRGPRX2 is exclusively expressed on mast cells and exhibits varying affinity for many molecules such as antimicrobial host defense peptides, neuropeptides, and even US Food and Drug Administration-approved drugs. The discovery of MRGPRX2 has changed our understanding of mast cell biology and filled the missing link of the underlying mechanism of drug-induced MC degranulation and pseudo-allergic reactions. These non-canonical characteristics render MRGPRX2 an intriguing player in allergic diseases. In the present article, we reviewed the emerging role of MRGPRX2 as a non-IgE-mediated mechanism of mast cell activation in pseudo-allergic reactions. We have presented an overview of mast cells, their receptors, structural insight into MRGPRX2, MRGPRX2 agonists and antagonists, the crucial role of MRGPRX2 in pseudo-allergic reactions, current challenges, and the future research direction.

Cisatracurium induces mast cell activation and pseudo-allergic reactions via MRGPRX2

2018 ◽  
Vol 62 ◽  
pp. 244-250 ◽  
Author(s):  
Delu Che ◽  
Liu Rui ◽  
Jiao Cao ◽  
Jue Wang ◽  
Yongjing Zhang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Allergic Reactions

scholarly journals Preventative and Therapeutic Effects of Low-dose Ionizing Radiation on the Allergic Response of Rat Basophilic Leukemia Cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hae Mi Joo ◽  
Eun Hee Hong ◽  
Seong-Jun Cho ◽  
Seon Young Nam ◽  
Ji Young Kim
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Ionizing Radiation ◽  
Therapeutic Effect ◽  
Cell Activation ◽  
Low Dose ◽  
Mast Cell Activation ◽  
Allergic Reactions ◽  
Antigen Antibody ◽  
Basophilic Leukemia

Abstract The prevalence of allergies has increased over the last four decades. In allergic reactions, mast cells induce a hypersensitive immune response to a substance that is normally harmless. Ionizing radiation has different biological effects depending on the dose and dose rate. In this study, we investigated whether low-dose irradiation before (preventative effect) or after (therapeutic effect) an antigen-antibody reaction has an anti-allergic effect. To test this, we activated rat basophilic leukemia (RBL-2H3) mast cells with anti-2,4-dinitrophenyl IgE (antibody) and 2,4-dinitrophenyl human serum albumin, which served as an antigen. To test for both the potential of a preventative effect and a therapeutic effect, we irradiated mast cells both before and after mast cell activation, and we measured mediator release and signaling pathway activity. Low-dose ionizing radiation suppressed mediator release from RBL-2H3 mast cells activated by the antigen-antibody reaction regardless of when the mast cells were irradiated. These results were due to the suppression of FcεRI expression. Therefore, we suggest that low-dose ionizing radiation has a preventative and therapeutic effect in allergic reactions via the FcεRI-mediated RBL-2H3 mast cell activation system.

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